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Pdcd6 Gene Detail
Summary
  • Symbol
    Pdcd6
  • Name
    programmed cell death 6
  • Synonyms
    alg-2, Alg2, MA-3, PS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109283
    NCBI Gene: 18570
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:74451628-74465699 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 40.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109283
 protein coding gene Chr13:74451240-74465699 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020762
 protein coding gene Chr13:74803700-74817840 (-)
A/J MGP_AJ_G0020718
 protein coding gene Chr13:72130761-72145726 (-)
AKR/J MGP_AKRJ_G0020692
 protein coding gene Chr13:74387036-74402812 (-)
BALB/cJ MGP_BALBcJ_G0020715
 protein coding gene Chr13:72624236-72638778 (-)
C3H/HeJ MGP_C3HHeJ_G0020509
 protein coding gene Chr13:74076096-74091946 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021152
 protein coding gene Chr13:77284192-77298397 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018719
 protein coding gene Chr13:68959338-68976023 (-)
CAST/EiJ MGP_CASTEiJ_G0020026
 protein coding gene Chr13:73160376-73175831 (-)
CBA/J MGP_CBAJ_G0020468
 protein coding gene Chr13:80158193-80172398 (-)
DBA/2J MGP_DBA2J_G0020593
 protein coding gene Chr13:71950041-71964246 (-)
FVB/NJ MGP_FVBNJ_G0020573
 protein coding gene Chr13:70973942-70988922 (-)
LP/J MGP_LPJ_G0020666
 protein coding gene Chr13:75038704-75052908 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020601
 protein coding gene Chr13:78562982-78577171 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021191
 protein coding gene Chr13:73709331-73723572 (-)
PWK/PhJ MGP_PWKPhJ_G0019780
 protein coding gene Chr13:70692292-70706689 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019603
 protein coding gene Chr13:70197303-70213687 (-)
WSB/EiJ MGP_WSBEiJ_G0020084
 protein coding gene Chr13:74262531-74279113 (-)



Homology
more
  • Human Ortholog
    PDCD6, programmed cell death 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDCD6, programmed cell death 6
  • Synonyms
    ALG-2, ALG2, PEF1B
  • Links
    NCBI Gene ID: 10016
    neXtProt AC: NX_O75340
    UniProt: O75340

  • Chr Location
    5p15.33; chr5:271621-314974 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Mice homozygous for a targeted null mutation are viable, fertile and do not exhibit any developmental defects or immune dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    117
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021576 Ensembl Gene Model | MGI Sequence Detail 14072 C57BL/6J ±  kb
transcript ENSMUST00000022060 Ensembl | MGI Sequence Detail 1131 Not Applicable  
polypeptide ENSMUSP00000022060 Ensembl | MGI Sequence Detail 191 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 117
    cDNA 117

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38328, MGI:2145399
References
more
  • Summaries
    All 59
    Diseases 1
    Gene Ontology 14
    Phenotypes 20
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:358278 Yang Y, et al., Erythrocytic alpha-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease. Mov Disord. 2024 Jan;39(1):40-52
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory