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Prkar1b Gene Detail
Summary
  • Symbol
    Prkar1b
  • Name
    protein kinase, cAMP dependent regulatory, type I beta
  • Synonyms
    RIbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:97759
    NCBI Gene: 19085
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139003061-139135756 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 77.74 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3735 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97759
 protein coding gene Chr5:139003059-139136458 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030275
 protein coding gene Chr5:143953778-144098319 (-)
A/J MGP_AJ_G0030244
 protein coding gene Chr5:137863929-138000674 (-)
AKR/J MGP_AKRJ_G0030176
 protein coding gene Chr5:142162221-142304339 (-)
BALB/cJ MGP_BALBcJ_G0030261
 protein coding gene Chr5:139106208-139246482 (-)
C3H/HeJ MGP_C3HHeJ_G0029972
 protein coding gene Chr5:142936409-143073763 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030706
 protein coding gene Chr5:149276323-149415760 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027924
 protein coding gene Chr5:131728635-131863421 (-)
CAST/EiJ MGP_CASTEiJ_G0029377
 protein coding gene Chr5:142336754-142486537 (-)
CBA/J MGP_CBAJ_G0029942
 protein coding gene Chr5:155419886-155575725 (-)
DBA/2J MGP_DBA2J_G0030092
 protein coding gene Chr5:137685204-137818913 (-)
FVB/NJ MGP_FVBNJ_G0030047
 protein coding gene Chr5:136773286-136915109 (-)
LP/J MGP_LPJ_G0030178
 protein coding gene Chr5:144577460-144722459 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030078
 protein coding gene Chr5:158126557-158268686 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030746
 protein coding gene Chr5:141963917-142112443 (-)
PWK/PhJ MGP_PWKPhJ_G0029092
 protein coding gene Chr5:136672657-136809003 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028928
 protein coding gene Chr5:139656910-139795901 (-)
WSB/EiJ MGP_WSBEiJ_G0029451
 protein coding gene Chr5:142723594-142873224 (-)



Homology
more
  • Human Ortholog
    PRKAR1B, protein kinase cAMP-dependent type I regulatory subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAR1B, protein kinase cAMP-dependent type I regulatory subunit beta
  • Synonyms
    MASNS, PRKAR1
  • Links
    NCBI Gene ID: 5575
    neXtProt AC: NX_P31321
    UniProt: P31321

  • Chr Location
    7p22.3; chr7:549197-728934 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have reduced LTD and LTP in specific CNS tracts, but normal neuroanatomy and behavior. Response to pain after inflammation is reduced, concurrent with decreased plasma extravasation during the inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    48
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1153
  • Tissues
    217
  • cDNA Data
    71
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025855 Ensembl Gene Model | MGI Sequence Detail 132696 C57BL/6J ±  kb
transcript ENSMUST00000026973 Ensembl | MGI Sequence Detail 2637 Not Applicable  
polypeptide ENSMUSP00000026973 Ensembl | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000013229 cAMP-dependent protein kinase type I-beta regulatory subunit
    (term hierarchy)
  • EC
    2.7.1.37
  • InterPro Domains
    IPR050503 cAMP-dependent kinase regulatory chain
    IPR012198 cAMP-dependent protein kinase regulatory subunit
    IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
    IPR018488 Cyclic nucleotide-binding, conserved site
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding domain superfamily
    IPR042818 RIbeta, dimerization/docking domain
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
less
  • All nucleic 84
    Genomic 10
    cDNA 71
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-13610, MGI:2140854
References
more
  • Summaries
    All 62
    Developmental Gene Expression 12
    Gene Ontology 16
    Phenotypes 10
  • Earliest
    J:39500 Clegg CH, et al., Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1988 Jun;85(11):3703-7
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory