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Vpreb1b Gene Detail
Summary
  • Symbol
    Vpreb1b
  • Name
    V-set pre-B cell surrogate light chain 1B
  • Synonyms
    Vpreb-2, Vpreb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98937
    NCBI Gene: 22363
  • Alliance
    gene page
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr16:17798292-17799137 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.14 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98937
 protein coding gene Chr16:17797314-17799138 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022562
 protein coding gene Chr16:13960054-13960800 (-)
A/J MGP_AJ_G0022523
 protein coding gene Chr16:13278125-13280441 (-)
AKR/J MGP_AKRJ_G0022501
 protein coding gene Chr16:13821295-13823511 (-)
BALB/cJ MGP_BALBcJ_G0022564
 protein coding gene Chr16:14566504-14573000 (+)
C3H/HeJ MGP_C3HHeJ_G0022332
 protein coding gene Chr16:15145053-15145525 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022978
 protein coding gene Chr16:14181831-14182333 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020497
 protein coding gene Chr16:13362215-13362961 (-)
CAST/EiJ MGP_CASTEiJ_G0021859
 protein coding gene Chr16:15045588-15046886 (+)
CBA/J MGP_CBAJ_G0022264
 protein coding gene Chr16:14842981-14845727 (-)
DBA/2J MGP_DBA2J_G0022432
 protein coding gene Chr16:14327836-14328543 (+)
FVB/NJ MGP_FVBNJ_G0022408
 protein coding gene Chr16:14378916-14379916 (+)
LP/J MGP_LPJ_G0022499
 protein coding gene Chr16:14960095-14962056 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022429
 protein coding gene Chr16:15773599-15774328 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0021565
 protein coding gene Chr16:13455900-13456476 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021392
 protein coding gene Chr16:13734233-13734978 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    VPREB1, V-set pre-B cell surrogate light chain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPREB1, V-set pre-B cell surrogate light chain 1
  • Synonyms
    CD179a, IGI, IGVPB, VPREB
  • Links
    NCBI Gene ID: 7441
    neXtProt AC: NX_P12018
    UniProt: P12018

  • Chr Location
    22q11.22; chr22:22244780-22245515 (+)  GRCh38
Human Diseases
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  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    135 phenotype references
Mice homozygous for null mutations at both Vpreb1 and Vpreb2 show impaired B-cell development. Fewer small pre-BII and immature B- cells are in bone marrow and numbers of B-cells in spleen and peritoneum are reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    8
  • cDNA Data
    2
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059280 Ensembl Gene Model | MGI Sequence Detail 846 C57BL/6J ±  kb
transcript ENSMUST00000075371 Ensembl | MGI Sequence Detail 759 Not Applicable  
polypeptide ENSMUSP00000074835 Ensembl | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    Genomic 6
    cDNA 3
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-15410, MGD-MRK-15413, MGI:7387117
References
more
  • Summaries
    All 154
    Developmental Gene Expression 2
    Diseases 6
    Gene Ontology 2
    Phenotypes 135
  • Earliest
    J:8871 Kudo A, et al., A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J. 1987 Aug;6(8):2267-72
  • Latest
    J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory