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Tnni2 Gene Detail
Summary
  • Symbol
    Tnni2
  • Name
    troponin I, skeletal, fast 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105070
    NCBI Gene: 21953
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141995553-141998147 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 87.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105070
 protein coding gene Chr7:141995545-141998147 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033256
 protein coding gene Chr7:147696587-147699189 (+)
A/J MGP_AJ_G0033239
 protein coding gene Chr7:143432558-143435160 (+)
AKR/J MGP_AKRJ_G0033171
 protein coding gene Chr7:147462450-147465052 (+)
BALB/cJ MGP_BALBcJ_G0033240
 protein coding gene Chr7:143206736-143209379 (+)
C3H/HeJ MGP_C3HHeJ_G0032955
 protein coding gene Chr7:147221824-147224426 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033750
 protein coding gene Chr7:153043548-153046150 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030723
 protein coding gene Chr7:144642378-144645057 (+)
CAST/EiJ MGP_CASTEiJ_G0032278
 protein coding gene Chr7:139529642-139532287 (+)
CBA/J MGP_CBAJ_G0032926
 protein coding gene Chr7:158289530-158292132 (+)
DBA/2J MGP_DBA2J_G0033080
 protein coding gene Chr7:141387553-141390155 (+)
FVB/NJ MGP_FVBNJ_G0033029
 protein coding gene Chr7:141322564-141325166 (+)
LP/J MGP_LPJ_G0033173
 protein coding gene Chr7:149208003-149210605 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033063
 protein coding gene Chr7:158907087-158909689 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033769
 protein coding gene Chr7:146409548-146412150 (+)
PWK/PhJ MGP_PWKPhJ_G0031986
 protein coding gene Chr7:134714663-134717306 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031832
 protein coding gene Chr7:133209545-133212187 (+)
WSB/EiJ MGP_WSBEiJ_G0032390
 protein coding gene Chr7:147388731-147391333 (+)



Homology
more
  • Human Ortholog
    TNNI2, troponin I2, fast skeletal type
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNNI2, troponin I2, fast skeletal type
  • Synonyms
    AMCD2B, DA2B, DA2B1, FSSV, fsTnI
  • Links
    NCBI Gene ID: 7136
    neXtProt AC: NX_P48788
    UniProt: P48788

  • Chr Location
    11p15.5; chr11:1838981-1841680 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tnni2 mouse models; 2 with human TNNI2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gain of function mutation exhibit impeded bone development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    37
  • cDNA Data
    104
  • Literature Summary
    47
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21953 NCBI Gene Model | MGI Sequence Detail 2595 C57BL/6J ±  kb
    transcript NM_009405 RefSeq | MGI Sequence Detail 724 ZRU/MplStud  
    polypeptide P13412 UniProt | EBI | MGI Sequence Detail 182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      cDNA 106
      Primer pair 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32109
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 47
      Diseases 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:31429 Koppe RI, et al., cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs. J Biol Chem. 1989 Aug 25;264(24):14327-33
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory