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Rpsa Gene Detail
Summary
  • Symbol
    Rpsa
  • Name
    ribosomal protein SA
  • Synonyms
    67lr, Lamr, Lamr1, Lamrl1, P40-3, P40-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:105381
    NCBI Gene: 16785
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:119956832-119961435 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    369 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105381
 protein coding gene Chr9:119956755-119961435 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035432
 protein coding gene Chr9:122951594-122960003 (+)
A/J MGP_AJ_G0035413
 protein coding gene Chr9:118345139-118349742 (+)
AKR/J MGP_AKRJ_G0035346
 protein coding gene Chr9:121445655-121454611 (+)
BALB/cJ MGP_BALBcJ_G0035409
 protein coding gene Chr9:118241651-118246254 (+)
C3H/HeJ MGP_C3HHeJ_G0035117
 protein coding gene Chr9:121925817-121930420 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035932
 protein coding gene Chr9:126315386-126321404 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032814
 protein coding gene Chr9:115546649-115551617 (+)
CAST/EiJ MGP_CASTEiJ_G0034421
 protein coding gene Chr9:121931295-121936097 (+)
CBA/J MGP_CBAJ_G0035084
 protein coding gene Chr9:131032242-131037174 (+)
DBA/2J MGP_DBA2J_G0035243
 protein coding gene Chr9:117795029-117800148 (+)
FVB/NJ MGP_FVBNJ_G0035190
 protein coding gene Chr9:116683700-116690395 (+)
LP/J MGP_LPJ_G0035322
 protein coding gene Chr9:123286403-123291033 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035231
 protein coding gene Chr9:131975210-131980760 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035951
 protein coding gene Chr9:121839721-121855304 (+)
PWK/PhJ MGP_PWKPhJ_G0034126
 protein coding gene Chr9:118235584-118242451 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033962
 protein coding gene Chr9:121941345-121947012 (+)
WSB/EiJ MGP_WSBEiJ_G0034541
 protein coding gene Chr9:121726821-121736002 (+)



Homology
more
  • Human Ortholog
    RPSA, ribosomal protein SA
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPSA, ribosomal protein SA
  • Synonyms
    37LRP, 67LR, ICAS, LAMBR, lamR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, p40, SA, uS2
  • Links
    NCBI Gene ID: 3921
    neXtProt AC: NX_P08865
    UniProt: P08865

  • Chr Location
    3p22.1; chr3:39406716-39426255 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Rpsa mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Spontaneous mutants show right ventricular cardiomyocyte degeneration and higher susceptibility to arrhythmia. Homozygous null mice fail to develop past E3.5; heterozygotes show craniofacial defects, low mean corpuscular hemoglobin concentration and reduced insulin content in pancreatic islet cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    69
  • cDNA Data
    32
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16785 NCBI Gene Model | MGI Sequence Detail 4604 C57BL/6J ±  kb
    transcript NM_011029 RefSeq | MGI Sequence Detail 1861 ZRU/MplStud  
    polypeptide P14206 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014293 eukaryotic-type small ribosomal subunit protein uS2
      (term hierarchy)
    • PDB
      7CPU, 7CPV, 7LS1, 7LS2
    • InterPro Domains
      IPR001865 Small ribosomal subunit protein uS2
      IPR018130 Small ribosomal subunit protein uS2, conserved site
      IPR032281 Small ribosomal subunit protein uS2, C-terminal domain
      IPR027498 Small ribosomal subunit protein uS2, eukaryotic
      IPR005707 Small ribosomal subunit protein uS2, eukaryotic/archaeal
      IPR023591 Small ribosomal subunit protein uS2, flavodoxin-like domain superfamily
      IPR027504 Small ribosomal subunit protein uS2, vertebrates
    • GlyGen
      P14206 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 37
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11746, MGD-MRK-13103, MGD-MRK-16686, MGD-MRK-33050, MGI:2144924, MGI:891974, MGI:97457, MGI:99891
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 15
      Diseases 2
      Gene Ontology 13
      Phenotypes 11
    • Earliest
      J:9131 Makrides S, et al., Nucleotide sequence for a major messenger RNA for a 40 kilodalton polypeptide that is under translational control in mouse tumor cells. Nucleic Acids Res. 1988 Mar 25;16(5):2349
    • Latest
      J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory