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Mecom Gene Detail
Summary
  • Symbol
    Mecom
  • Name
    MDS1 and EVI1 complex locus
  • Synonyms
    D630039M04Rik, Evi-1, Evi1, Jbo, Mds1, MDS1-EVI1, Prdm3, ZNFPR1B1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95457
    NCBI Gene: 14013
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:30005445-30563937 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 12.66 cM
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13820 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95457
 protein coding gene Chr3:30005445-30602157 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027120
 protein coding gene Chr3:27407579-28043200 (-)
A/J MGP_AJ_G0027080
 protein coding gene Chr3:27081102-27676160 (-)
AKR/J MGP_AKRJ_G0027049
 protein coding gene Chr3:27483774-28094548 (-)
BALB/cJ MGP_BALBcJ_G0027092
 protein coding gene Chr3:26775250-27376226 (-)
C3H/HeJ MGP_C3HHeJ_G0026834
 protein coding gene Chr3:27513077-28130405 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027538
 protein coding gene Chr3:28909572-29541089 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024899
 protein coding gene Chr3:25006205-25596749 (-)
CAST/EiJ MGP_CASTEiJ_G0026288
 protein coding gene Chr3:27379058-28016806 (-)
CBA/J MGP_CBAJ_G0026812
 protein coding gene Chr3:29634934-30270696 (-)
DBA/2J MGP_DBA2J_G0026946
 protein coding gene Chr3:26642290-27234276 (-)
FVB/NJ MGP_FVBNJ_G0026914
 protein coding gene Chr3:26091656-26684277 (-)
LP/J MGP_LPJ_G0027057
 protein coding gene Chr3:28102052-28719670 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026934
 protein coding gene Chr3:32231839-32877868 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027597
 protein coding gene Chr3:27220842-27837090 (-)
PWK/PhJ MGP_PWKPhJ_G0026021
 protein coding gene Chr3:26129230-26733502 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025833
 protein coding gene Chr3:26721993-27350198 (-)
WSB/EiJ MGP_WSBEiJ_G0026362
 protein coding gene Chr3:27310137-27942337 (-)



Homology
more
  • Human Ortholog
    MECOM, MDS1 and EVI1 complex locus
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MECOM, MDS1 and EVI1 complex locus
  • Synonyms
    AML1-EVI-1, EVI1, KMT8E, MDS1, MDS1-EVI1, PRDM3, RUSAT2
  • Links
    NCBI Gene ID: 2122
    neXtProt AC: NX_Q03112
    UniProt: Q03112

  • Chr Location
    3q26.2; chr3:169083499-169663775 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mecom mouse models; 1 with human MECOM associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    125 phenotypes from 9 alleles in 15 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted null mutation die at 10.5 dpc displaying widespread hypocellularity, hemorrhage, and disruption in the development of the heart, somites, and neural crest-derived cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    63
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1137
  • Tissues
    287
  • cDNA Data
    23
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14013 NCBI Gene Model | MGI Sequence Detail 558493 C57BL/6J ±  kb
    transcript NM_001361034 RefSeq | MGI Sequence Detail 5439 C57BL/6  
    polypeptide P14404 UniProt | EBI | MGI Sequence Detail 1232 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 8
      cDNA 23
      Primer pair 5
      Other 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-9667, MGD-MRK-9670, MGI:1329024, MGI:2158364, MGI:2443042
    References
    more
    • Summaries
      All 162
      Developmental Gene Expression 32
      Diseases 3
      Gene Ontology 20
      Phenotypes 52
    • Earliest
      J:6439 Chattopadhyay SK, et al., Structure of endogenous murine leukemia virus DNA in mouse genomes. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5774-8
    • Latest
      J:354192 He H, et al., PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. Nat Commun. 2024 Sep 16;15(1):8112
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory