Jund MGI Mouse Gene Detail - MGI:96648

Symbol

Jund
Name

jun D proto-oncogene

Feature Type

protein coding gene
IDs

MGI:96648
NCBI Gene: 16478
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:71151599-71153265 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.15 cM, cytoband C2
Mapping Data

23 experiments

SNPs within 2kb

61 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96648	protein coding gene	Chr8:71150389-71153265 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033719	protein coding gene	Chr8:70986507-70989904 (+)
A/J	MGP_AJ_G0033702	protein coding gene	Chr8:68101363-68105303 (+)
AKR/J	MGP_AKRJ_G0033627	protein coding gene	Chr8:70048231-70051105 (+)
BALB/cJ	MGP_BALBcJ_G0033698	protein coding gene	Chr8:68335579-68338485 (+)
C3H/HeJ	MGP_C3HHeJ_G0033408	protein coding gene	Chr8:70689290-70692193 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034215	protein coding gene	Chr8:73659962-73662838 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031159	protein coding gene	Chr8:62915905-62918796 (+)
CAST/EiJ	MGP_CASTEiJ_G0032733	protein coding gene	Chr8:70171705-70174627 (+)
CBA/J	MGP_CBAJ_G0033386	protein coding gene	Chr8:76322664-76325580 (+)
DBA/2J	MGP_DBA2J_G0033540	protein coding gene	Chr8:67815967-67818959 (+)
FVB/NJ	MGP_FVBNJ_G0033481	protein coding gene	Chr8:66940793-66943665 (+)
LP/J	MGP_LPJ_G0033627	protein coding gene	Chr8:71009053-71011925 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033524	protein coding gene	Chr8:78966766-78969644 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034233	protein coding gene	Chr8:70225464-70229314 (+)
PWK/PhJ	MGP_PWKPhJ_G0032441	protein coding gene	Chr8:67117026-67119975 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032277	protein coding gene	Chr8:69195713-69198603 (+)
WSB/EiJ	MGP_WSBEiJ_G0032848	protein coding gene	Chr8:70597987-70600868 (+)

Human Ortholog

JUND, JunD proto-oncogene, AP-1 transcription factor subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

JUND, JunD proto-oncogene, AP-1 transcription factor subunit
Synonyms

AP-1
Links

HGNC:6206

NCBI Gene ID: 3727

neXtProt AC: NX_P17535

UniProt: P17535
Chr Location

19p13.11; chr19:18279694-18281622 (-) GRCh38

MGI Vertebrate Homology

Jund stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: JUND
Gene Tree

Jund

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

31 phenotypes from 2 alleles in 4 genetic backgrounds
18 phenotypes from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Transgenic

1
Genomic Mutations

1 involving Jund
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes show reduced growth, sensitivity to LPS-induced hepatitis, and male infertility due to hormonal imbalance and impaired spermatogenesis. Targeted cells and mice are sensitive to p53-dependent stress and TNF-induced apoptosis, and show aberrantT cell proliferation and Th2 differentiation.

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All GO Annotations

51
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

893
Tissues

181
cDNA Data

19
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase jund, jund.2

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All Sequences

45
RefSeq

4
UniProt

2
CCDS

CCDS40375.1

Ensembl

ENSMUSG00000071076 (Evidence)
NCBI Gene

16478

			Length	Strain/Species	Flank
genomic	ENSMUSG00000071076	Ensembl Gene Model \| MGI Sequence Detail	1667	C57BL/6J	± kb
transcript	ENSMUST00000095267	Ensembl \| MGI Sequence Detail	1667	Not Applicable
polypeptide	ENSMUSP00000092901	Ensembl \| MGI Sequence Detail	341	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009234 transcription factor JunD

(term hierarchy)
InterPro Domains

IPR050946 AP-1 Transcription Factor bZIP

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

IPR005643 Jun-like transcription factor

IPR002112 Transcription factor Jun

IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
GlyGen

P15066 1 site, 1 O-linked glycan (1 site)

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All nucleic 27

Genomic 1

cDNA 21

Primer pair 3

Other 2

Microarray probesets 3

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MGD-MRK-11541, MGD-MRK-11542

Summaries

All 108

Developmental Gene Expression 15

Diseases 1

Gene Ontology 14

Phenotypes 27
Earliest

J:9466 Nakabeppu Y, et al., DNA binding activities of three murine Jun proteins: stimulation by Fos. Cell. 1988 Dec 2;55(5):907-15
Latest

J:333149 Zhao T, et al., Sertoli cell PUMILIO proteins modulate mouse testis size through translational control of cell cycle regulators. Biol Reprod. 2022 Jul 25;107(1):135-147

TSS for Jund:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77799	Chr8:71151176-71151195 (+)	-413 bp
Tssr77800	Chr8:71151581-71151595 (+)	-11 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24