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Cdh2 Gene Detail
Summary
  • Symbol
    Cdh2
  • Name
    cadherin 2
  • Synonyms
    Ncad, N-CAD, N-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88355
    NCBI Gene: 12558
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:16721934-16942303 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 10.10 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6379 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88355
 protein coding gene Chr18:16721934-16942303 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024174
 protein coding gene Chr18:13983125-14210687 (-)
A/J MGP_AJ_G0024137
 protein coding gene Chr18:13650667-13872030 (-)
AKR/J MGP_AKRJ_G0024104
 protein coding gene Chr18:14109459-14332373 (-)
BALB/cJ MGP_BALBcJ_G0024136
 protein coding gene Chr18:13583385-13802852 (-)
C3H/HeJ MGP_C3HHeJ_G0023904
 protein coding gene Chr18:13960498-14190309 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024580
 protein coding gene Chr18:14616660-14847621 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022020
 protein coding gene Chr18:13061484-13279630 (-)
CAST/EiJ MGP_CASTEiJ_G0023380
 protein coding gene Chr18:13883739-14106019 (-)
CBA/J MGP_CBAJ_G0023874
 protein coding gene Chr18:14885465-15119091 (-)
DBA/2J MGP_DBA2J_G0024004
 protein coding gene Chr18:13436725-13661731 (-)
FVB/NJ MGP_FVBNJ_G0023969
 protein coding gene Chr18:13260673-13480751 (-)
LP/J MGP_LPJ_G0024087
 protein coding gene Chr18:14072044-14300044 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023998
 protein coding gene Chr18:15043305-15282727 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024627
 protein coding gene Chr18:13824494-14051301 (-)
PWK/PhJ MGP_PWKPhJ_G0023125
 protein coding gene Chr18:13577003-13796454 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022934
 protein coding gene Chr18:14114352-14348907 (-)
WSB/EiJ MGP_WSBEiJ_G0023445
 protein coding gene Chr18:13776857-14004973 (-)



Homology
more
  • Human Ortholog
    CDH2, cadherin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDH2, cadherin 2
  • Synonyms
    ACOGS, ADHD8, ARVD14, CD325, CDHN, CDw325, NCAD
  • Links
    NCBI Gene ID: 1000
    neXtProt AC: NX_P19022
    UniProt: P19022

  • Chr Location
    18q12.1; chr18:27932879-28177946 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cdh2 mouse models; 3 with human CDH2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 6 alleles in 9 genetic backgrounds
    1 phenotype from multigenic genotypes
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in death by E10. Mutant embryos exhibit several developmental abnormalities such as growth retardation, an enlarged heart, distended pericardial sacs, abnormal heart tube, wavy neural tube, irregular somite shape, and abnormal embryo turning. Homozygosity for proteolytic cleavage resistance mutations affects hippocampus pyramidal neuron synapse morphology and physiology, leading to fear generalization and enhanced spatial working memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    129
  • GO References
    51
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2103
  • Tissues
    501
  • cDNA Data
    27
  • Literature Summary
    488
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12558 NCBI Gene Model | MGI Sequence Detail 220370 C57BL/6J ±  kb
    transcript NM_007664 RefSeq | MGI Sequence Detail 4858 ZRU/MplStud  
    polypeptide P15116 UniProt | EBI | MGI Sequence Detail 906 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      Genomic 19
      cDNA 33
      Primer pair 17
      Other 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12785, MGD-MRK-1882
    References
    more
    • Summaries
      All 698
      Developmental Gene Expression 488
      Diseases 1
      Gene Ontology 51
      Phenotypes 85
    • Earliest
      J:14761 Miyatani S, et al., Neural cadherin: role in selective cell-cell adhesion. Science. 1989 Aug 11;245(4918):631-5
    • Latest
      J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory