Irf1 MGI Mouse Gene Detail - MGI:96590 - interferon regulatory factor 1

Symbol

Irf1
Name

interferon regulatory factor 1
Synonyms

Irf-1

Feature Type

protein coding gene
IDs

MGI:96590
NCBI Gene: 16362
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:53660841-53669200 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 32.00 cM
Mapping Data

10 experiments

SNPs within 2kb

262 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96590	protein coding gene	Chr11:53660841-53669200 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018304	protein coding gene	Chr11:53188448-53196807 (+)
A/J	MGP_AJ_G0018273	protein coding gene	Chr11:51176180-51184539 (+)
AKR/J	MGP_AKRJ_G0018243	protein coding gene	Chr11:52855618-52863977 (+)
BALB/cJ	MGP_BALBcJ_G0018244	protein coding gene	Chr11:51531491-51540156 (+)
C3H/HeJ	MGP_C3HHeJ_G0018055	protein coding gene	Chr11:52825546-52833905 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018696	protein coding gene	Chr11:54790564-54798923 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016346	protein coding gene	Chr11:48706888-48715085 (+)
CAST/EiJ	MGP_CASTEiJ_G0017620	protein coding gene	Chr11:52866530-52889182 (+)
CBA/J	MGP_CBAJ_G0018030	protein coding gene	Chr11:57395944-57404303 (+)
DBA/2J	MGP_DBA2J_G0018140	protein coding gene	Chr11:50922593-50930969 (+)
FVB/NJ	MGP_FVBNJ_G0018132	protein coding gene	Chr11:50566856-50575215 (+)
LP/J	MGP_LPJ_G0018214	protein coding gene	Chr11:53635714-53644877 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018156	protein coding gene	Chr11:58674787-58683145 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018738	protein coding gene	Chr11:52885706-52895414 (+)
PWK/PhJ	MGP_PWKPhJ_G0017395	protein coding gene	Chr11:51441920-51461148 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017190	protein coding gene	Chr11:52676276-52684586 (+)
WSB/EiJ	MGP_WSBEiJ_G0017667	protein coding gene	Chr11:52521141-52531505 (+)

Human Ortholog

IRF1, interferon regulatory factor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRF1, interferon regulatory factor 1
Synonyms

IMD117, IRF-1, MAR
Links

HGNC:6116

NCBI Gene ID: 3659

neXtProt AC: NX_P10914

UniProt: P10914
Chr Location

5q31.1; chr5:132440440-132508719 (-) GRCh38

MGI Vertebrate Homology

Irf1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IRF1
Protein SuperFamily

IFN_RF1/2
Gene Tree

Irf1

Diseases

7 with human IRF1 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				gastric adenocarcinoma IDs gastric adenocarcinoma DOID:3717 NCI:C4004 UMLS_CUI:C0278701
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051
				smallpox IDs smallpox DOID:8736 ICD10CM:B03 ICD9CM:050 ICD9CM:050.9 MESH:D012899 NCI:C35027 UMLS_CUI:C0037354
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

47 phenotypes from 5 alleles in 9 genetic backgrounds
18 phenotypes from multigenic genotypes
178 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (ENU)

3
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

4
Targeted

6
Genomic Mutations

2 involving Irf1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous disruption of this gene leads to reduced CD8+ T cell number and altered response to viral infection and may cause alterations in cytokine levels, CD4+ cell subset homeostasis, blood vessel healing, DNA repair, and susceptibility to induced lymphomas, arthritis and autoimmune encephalitis.

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All GO Annotations

77
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

853
Tissues

74
cDNA Data

160
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase irf1

ZFIN irf1a, irf1b

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All Sequences

71
RefSeq

8
UniProt

9
CCDS

CCDS24686.1, CCDS48796.1

Ensembl

ENSMUSG00000018899 (Evidence)
NCBI Gene

16362

			Length	Strain/Species	Flank
genomic	16362	NCBI Gene Model \| MGI Sequence Detail	8360	C57BL/6J	± kb
transcript	NM_008390	RefSeq \| MGI Sequence Detail	2151	ZRU/MplStud
polypeptide	P15314	UniProt \| EBI \| MGI Sequence Detail	329	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000002043 interferon regulatory factor 1

(term hierarchy)
PDB

1IF1
InterPro Domains

IPR017431 Interferon regulatory factor-1/2

IPR019817 Interferon regulatory factor, conserved site

IPR001346 Interferon regulatory factor, DNA-binding domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 179

Genomic 12

cDNA 163

Primer pair 4

Microarray probesets 3

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MGD-MRK-11464, MGD-MRK-11465, MGI:2144403

Summaries

All 290

Developmental Gene Expression 15

Gene Ontology 22

Phenotypes 178
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:352683 Purbey PK, et al., Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity. Cell Rep. 2024 Jun 25;43(6):114289

TSS for Irf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101450	Chr11:53660869-53660884 (+)	36 bp
Tssr101451	Chr11:53661284-53661331 (+)	467 bp
Tssr101452	Chr11:53661632-53661649 (+)	800 bp
Tssr101453	Chr11:53661803-53661806 (+)	964 bp
Tssr101454	Chr11:53662093-53662103 (+)	1,257 bp
Tssr101455	Chr11:53662198-53662214 (+)	1,365 bp
Tssr101456	Chr11:53662536-53662548 (+)	1,701 bp
Tssr101457	Chr11:53662583-53662594 (+)	1,748 bp
Tssr101458	Chr11:53662896-53662913 (+)	2,064 bp
Tssr101459	Chr11:53662933-53662953 (+)	2,102 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24