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Cd44 Gene Detail
Summary
  • Symbol
    Cd44
  • Name
    CD44 antigen
  • Synonyms
    HERMES, Ly-24, Pgp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88338
    NCBI Gene: 12505
  • Alliance
    gene page
  • Transcription Start Sites
    43 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:102641486-102732010 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 54.13 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88338
 protein coding gene Chr2:102641486-102732014 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026199
 protein coding gene Chr2:104741863-104846292 (-)
A/J MGP_AJ_G0026160
 protein coding gene Chr2:100439949-100532666 (-)
AKR/J MGP_AKRJ_G0026141
 protein coding gene Chr2:103151124-103244929 (-)
BALB/cJ MGP_BALBcJ_G0026169
 protein coding gene Chr2:100714952-100809028 (-)
C3H/HeJ MGP_C3HHeJ_G0025920
 protein coding gene Chr2:103521353-103613937 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026620
 protein coding gene Chr2:108266700-108386727 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024011
 protein coding gene Chr2:96114085-96203109 (-)
CAST/EiJ MGP_CASTEiJ_G0025385
 protein coding gene Chr2:103962115-104055803 (-)
CBA/J MGP_CBAJ_G0025898
 protein coding gene Chr2:111978219-112077284 (-)
DBA/2J MGP_DBA2J_G0026034
 protein coding gene Chr2:100001378-100091791 (-)
FVB/NJ MGP_FVBNJ_G0025997
 protein coding gene Chr2:99003704-99095656 (-)
LP/J MGP_LPJ_G0026138
 protein coding gene Chr2:104890932-104987502 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026023
 protein coding gene Chr2:115930542-116027717 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026674
 protein coding gene Chr2:103371425-103465940 (-)
PWK/PhJ MGP_PWKPhJ_G0025120
 protein coding gene Chr2:99500466-99592033 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024921
 protein coding gene Chr2:102594268-102691052 (-)
WSB/EiJ MGP_WSBEiJ_G0025452
 protein coding gene Chr2:104076025-104169657 (-)



Homology
more
  • Human Ortholog
    CD44, CD44 molecule (IN blood group)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD44, CD44 molecule (IN blood group)
  • Synonyms
    CDW44, CSPG8, ECM-III, ECMR-III, H-CAM, HCELL, Hermes-1, HUTCH-1, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1
  • Links
    NCBI Gene ID: 960
    neXtProt AC: NX_P16070
    UniProt: P16070

  • Chr Location
    11p13; chr11:35138882-35232402 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human CD44 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    90 phenotypes from 10 alleles in 16 genetic backgrounds
    48 phenotypes from multigenic genotypes
    213 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired T lymphocyte trafficking resulting in muted inflammatory responses, altered myeloid progenitor distribution, reduced growth of tumors, and impaired uterine involution and maintenance of lactation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    57
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1278
  • Tissues
    338
  • cDNA Data
    42
  • Literature Summary
    120
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005087 Ensembl Gene Model | MGI Sequence Detail 90525 C57BL/6J ±  kb
    transcript ENSMUST00000005218 Ensembl | MGI Sequence Detail 5614 Not Applicable  
    polypeptide ENSMUSP00000005218 Ensembl | MGI Sequence Detail 780 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      Genomic 3
      cDNA 42
      Primer pair 36
      Other 2

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-11964, MGD-MRK-13281, MGD-MRK-1863, MGI:2139311, MGI:2139322, MGI:3035411
    References
    more
    • Summaries
      All 519
      Developmental Gene Expression 120
      Gene Ontology 57
      Phenotypes 213
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:351035 Tan Z, et al., Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration. Cell Rep. 2024 Jun 25;43(6):114342
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory