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Cd79b Gene Detail
Summary
  • Symbol
    Cd79b
  • Name
    CD79B antigen
  • Synonyms
    B29, Igb, Ig-beta, Igbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:96431
    NCBI Gene: 15985
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106202167-106205388 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 68.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96431
 protein coding gene Chr11:106202167-106205588 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019304
 protein coding gene Chr11:109601842-109605265 (-)
A/J MGP_AJ_G0019272
 protein coding gene Chr11:104936582-104940027 (-)
AKR/J MGP_AKRJ_G0019241
 protein coding gene Chr11:108066024-108069445 (-)
BALB/cJ MGP_BALBcJ_G0019246
 protein coding gene Chr11:105343483-105346904 (-)
C3H/HeJ MGP_C3HHeJ_G0019055
 protein coding gene Chr11:108352943-108356364 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019696
 protein coding gene Chr11:112954881-112958302 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017320
 protein coding gene Chr11:102211210-102214609 (-)
CAST/EiJ MGP_CASTEiJ_G0018608
 protein coding gene Chr11:109411470-109415989 (-)
CBA/J MGP_CBAJ_G0019024
 protein coding gene Chr11:117657211-117660634 (-)
DBA/2J MGP_DBA2J_G0019136
 protein coding gene Chr11:104404638-104408059 (-)
FVB/NJ MGP_FVBNJ_G0019127
 protein coding gene Chr11:103909591-103913012 (-)
LP/J MGP_LPJ_G0019206
 protein coding gene Chr11:110043864-110047287 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019157
 protein coding gene Chr11:116934513-116937936 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019733
 protein coding gene Chr11:108556616-108560049 (-)
PWK/PhJ MGP_PWKPhJ_G0018373
 protein coding gene Chr11:105500148-105503613 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018164
 protein coding gene Chr11:108322848-108326362 (-)
WSB/EiJ MGP_WSBEiJ_G0018659
 protein coding gene Chr11:108516670-108520119 (-)



Homology
more
  • Human Ortholog
    CD79B, CD79b molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD79B, CD79b molecule
  • Synonyms
    AGM6, B29, IGB, Igbeta
  • Links
    NCBI Gene ID: 974
    neXtProt AC: NX_P40259
    UniProt: P40259

  • Chr Location
    17q23.3; chr17:63928738-63932336 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human CD79B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 9 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit arrested development of B cells at the pro-B cell stage due to diminished signaling of the B cell receptor.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    47
  • cDNA Data
    34
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15985 NCBI Gene Model | MGI Sequence Detail 3222 C57BL/6J ±  kb
    transcript NM_008339 RefSeq | MGI Sequence Detail 1249 ZRU/MplStud  
    polypeptide P15530 UniProt | EBI | MGI Sequence Detail 228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 1
      cDNA 34
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11225
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 27
    • Earliest
      J:17556 Hermanson GG, et al., B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6890-4
    • Latest
      J:351007 Flumann R, et al., An inducible Cd79b mutation confers ibrutinib sensitivity in mouse models of Myd88-driven diffuse large B-cell lymphoma. Blood Adv. 2024 Mar 12;8(5):1063-1074
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory