Nme1 MGI Mouse Gene Detail - MGI:97355 - NME/NM23 nucleoside diphosphate kinase 1

Symbol

Nme1
Name

NME/NM23 nucleoside diphosphate kinase 1
Synonyms

NDPK-A, NM23-M1, non-metastatic cells 1, protein (NM23A) expressed in

Feature Type

protein coding gene
IDs

MGI:97355
NCBI Gene: 18102
Alliance

gene page

Sequence Map

Chr11:93849751-93859341 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 58.89 cM
Mapping Data

2 experiments

SNPs within 2kb

382 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97355	protein coding gene	Chr11:93847805-93859347 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018948	protein coding gene	Chr11:95985506-96001280 (-)
A/J	MGP_AJ_G0018916	protein coding gene	Chr11:92187436-92198875 (-)
AKR/J	MGP_AKRJ_G0018886	protein coding gene	Chr11:95060561-95072425 (-)
BALB/cJ	MGP_BALBcJ_G0018889	protein coding gene	Chr11:92613706-92626172 (-)
C3H/HeJ	MGP_C3HHeJ_G0018703	protein coding gene	Chr11:95132509-95143912 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019341	protein coding gene	Chr11:98982590-98995894 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016972	protein coding gene	Chr11:89678153-89689743 (-)
CAST/EiJ	MGP_CASTEiJ_G0018258	protein coding gene	Chr11:95819308-95830801 (-)
CBA/J	MGP_CBAJ_G0018674	protein coding gene	Chr11:103091763-103106516 (-)
DBA/2J	MGP_DBA2J_G0018782	protein coding gene	Chr11:91750790-91762692 (-)
FVB/NJ	MGP_FVBNJ_G0018771	protein coding gene	Chr11:91169171-91180633 (-)
LP/J	MGP_LPJ_G0018852	protein coding gene	Chr11:96545136-96563762 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018798	protein coding gene	Chr11:103145813-103162609 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019381	protein coding gene	Chr11:95246291-95260423 (-)
PWK/PhJ	MGP_PWKPhJ_G0018028	protein coding gene	Chr11:92671011-92683946 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017818	protein coding gene	Chr11:94934695-94948247 (-)
WSB/EiJ	MGP_WSBEiJ_G0018307	protein coding gene	Chr11:95129603-95143027 (-)

Human Ortholog

NME1, NME/NM23 nucleoside diphosphate kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NME1, NME/NM23 nucleoside diphosphate kinase 1
Synonyms

AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1
Links

HGNC:7849

NCBI Gene ID: 4830

neXtProt AC: NX_P15531

UniProt: P15531
Chr Location

17q21.33; chr17:51153559-51162428 (+) GRCh38

MGI Vertebrate Homology

Nme1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NME1
Gene Tree

Nme1

Diseases

3 with human NME1 associations

				Human Disease	Mouse Models
				neuroblastoma IDs neuroblastoma DOID:769 EFO:0000621 MESH:D009447 NCI:C3270 ORDO:635 UMLS_CUI:C0027819
				ovary epithelial cancer IDs ovary epithelial cancer DOID:2152 NCI:C4381 UMLS_CUI:C0341823
				teratoma IDs teratoma DOID:3307 MESH:D013724 NCI:C3403 UMLS_CUI:C0039538

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 1 allele in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

1
Targeted

8
Genomic Mutations

4 involving Nme1
Incidental Mutations

APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice for a targeted mutation of this gene are born normally, but exhibited high perinatal mortality of all genotypes on congenic backgrounds. This appears to be a maternal effect because the presence of a single functioning allele in females can prevent this mortality.

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All GO Annotations

54
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1113
Tissues

247
cDNA Data

212
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

51
RefSeq

8
UniProt

4
CCDS

CCDS25247.1

Ensembl

ENSMUSG00000037601 (Evidence)
NCBI Gene

18102

			Length	Strain/Species	Flank
genomic	18102	NCBI Gene Model \| MGI Sequence Detail	9591	C57BL/6J	± kb
transcript	NM_001378854	RefSeq \| MGI Sequence Detail	999	C57BL/6
polypeptide	P15532	UniProt \| EBI \| MGI Sequence Detail	152	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011281 nucleoside diphosphate kinase A

(term hierarchy)
PDB

7ZL8, 7ZLW, 7ZTK
EC

2.7.4.6
InterPro Domains

IPR001564 Nucleoside diphosphate kinase

IPR023005 Nucleoside diphosphate kinase, active site

IPR034907 Nucleoside diphosphate kinase-like domain

IPR036850 Nucleoside diphosphate kinase-like domain superfamily
GlyGen

P15532 1 site, 1 O-linked glycan (1 site)

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All nucleic 222

cDNA 214

Primer pair 1

Other 7

Microarray probesets 5

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MGD-MRK-12901, MGI:2144352

Summaries

All 77

Developmental Gene Expression 11

Diseases 1

Gene Ontology 13

Phenotypes 19
Earliest

J:15840 Steeg PS, et al., Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst. 1988 Apr 6;80(3):200-4
Latest

J:339369 Kaur G, et al., Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic beta cells resulting in neonatal lethality. PLoS One. 2023;18(8):e0286109

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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