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Klk1b5 Gene Detail
Summary
  • Symbol
    Klk1b5
  • Name
    kallikrein 1-related peptidase b5
  • Synonyms
    Klk5, mGK-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:892020
    NCBI Gene: 16622
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43865898-43870127 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.73 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    2
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892020
 protein coding gene Chr7:43865369-43870127 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0032635
 protein coding gene Chr7:46604628-46608926 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KLK1, kallikrein 1
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLK1, kallikrein 1
  • Synonyms
    hK1, Klk6, KLKR
  • Links
    NCBI Gene ID: 3816
    neXtProt AC: NX_P06870
    UniProt: P06870

  • Chr Location
    19q13.33; chr19:50819146-50823787 (-)  GRCh38
  • Human Ortholog
    KLK2, kallikrein related peptidase 2
  • Synonyms
    hGK-1, hK2, KLK2A2
  • Links
    NCBI Gene ID: 3817
    neXtProt AC: NX_P20151
    UniProt: P20151

  • Chr Location
    19q13.33; chr19:50861568-50880567 (+)  GRCh38
  • Human Ortholog
    KLK3, kallikrein related peptidase 3
  • Synonyms
    APS, hK3, KLK2A1, PSA
  • Links
    NCBI Gene ID: 354
    neXtProt AC: NX_P07288
    UniProt: P07288

  • Chr Location
    19q13.33; chr19:50854915-50860764 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human KLK1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotype references
Mice homozygous for a null mutation display normal fertility, growth, and submandibular gland morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    10
  • cDNA Data
    3
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16622 NCBI Gene Model | MGI Sequence Detail 4230 C57BL/6J ±  kb
transcript NM_008456 RefSeq | MGI Sequence Detail 862 ZRU/MplStud  
polypeptide P15945 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 91
    Genomic 83
    cDNA 5
    Primer pair 3

    Microarray probesets 5
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:7072 Mason AJ, et al., Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature. 1983 May 26;303(5915):300-7
  • Latest
    J:290000 Li S, et al., Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in mice. Mol Reprod Dev. 2019 Jun;86(6):611-613
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory