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Met Gene Detail
Summary
  • Symbol
    Met
  • Name
    met proto-oncogene
  • Synonyms
    c-Met, HGF receptor, Par4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96969
    NCBI Gene: 17295
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:17463799-17573979 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 7.83 cM, cytoband A2
  • Mapping Data
    48 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3452 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96969
 protein coding gene Chr6:17463351-17573979 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030470
 protein coding gene Chr6:14711251-14826916 (+)
A/J MGP_AJ_G0030443
 protein coding gene Chr6:14114561-14223873 (+)
AKR/J MGP_AKRJ_G0030370
 protein coding gene Chr6:14609364-14719673 (+)
BALB/cJ MGP_BALBcJ_G0030452
 protein coding gene Chr6:14201413-14310538 (+)
C3H/HeJ MGP_C3HHeJ_G0030166
 protein coding gene Chr6:14475187-14586969 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030907
 protein coding gene Chr6:15165870-15287061 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028118
 protein coding gene Chr6:13078802-13187922 (+)
CAST/EiJ MGP_CASTEiJ_G0029568
 protein coding gene Chr6:14371859-14489616 (+)
CBA/J MGP_CBAJ_G0030144
 protein coding gene Chr6:15661669-15787158 (+)
DBA/2J MGP_DBA2J_G0030288
 protein coding gene Chr6:14038682-14156914 (+)
FVB/NJ MGP_FVBNJ_G0030242
 protein coding gene Chr6:13881162-13992183 (+)
LP/J MGP_LPJ_G0030375
 protein coding gene Chr6:14787654-14908342 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030278
 protein coding gene Chr6:16848367-16963869 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030937
 protein coding gene Chr6:14485053-14600551 (+)
PWK/PhJ MGP_PWKPhJ_G0029282
 protein coding gene Chr6:13688603-13800808 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029118
 protein coding gene Chr6:14363875-14478353 (+)
WSB/EiJ MGP_WSBEiJ_G0029644
 protein coding gene Chr6:14428737-14543450 (+)



Homology
more
  • Human Ortholog
    MET, MET proto-oncogene, receptor tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MET, MET proto-oncogene, receptor tyrosine kinase
  • Synonyms
    AUTS9, c-Met, DA11, DFNB97, HGFR, RCCP2
  • Links
    NCBI Gene ID: 4233
    neXtProt AC: NX_P08581
    UniProt: P08581

  • Chr Location
    7q31.2; chr7:116672196-116798377 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Met mouse models; 8 with human MET associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    78 phenotypes from 12 alleles in 14 genetic backgrounds
    50 phenotypes from multigenic genotypes
    1 images
    112 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit impaired embryonic development resulting in death. Abnormalities observed in various mutant lines include muscle agenesis due to impaired migration of myogenic precursors, defects of motor axon migration, and placental and liver defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    125
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1285
  • Tissues
    355
  • cDNA Data
    89
  • Literature Summary
    114
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009376 Ensembl Gene Model | MGI Sequence Detail 110181 C57BL/6J ±  kb
    transcript ENSMUST00000115443 Ensembl | MGI Sequence Detail 6809 Not Applicable  
    polypeptide ENSMUSP00000111103 Ensembl | MGI Sequence Detail 1379 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 125
      Genomic 14
      cDNA 91
      Primer pair 13
      Other 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12203, MGI:1197520, MGI:2141478
    References
    more
    • Summaries
      All 360
      Developmental Gene Expression 114
      Diseases 3
      Gene Ontology 25
      Phenotypes 112
    • Earliest
      J:8287 Park M, et al., Mechanism of met oncogene activation. Cell. 1986 Jun 20;45(6):895-904
    • Latest
      J:351261 Lanjewar AL, et al., Developmental and molecular contributions to contextual fear memory emergence in mice. Neuropsychopharmacology. 2024;49(9):1392-1401
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory