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Il4ra Gene Detail
Summary
  • Symbol
    Il4ra
  • Name
    interleukin 4 receptor, alpha
  • Synonyms
    CD124, Il4r, IL-4 receptor alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:105367
    NCBI Gene: 16190
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr7:125151443-125178646 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 68.94 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    872 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105367
 protein coding gene Chr7:125151292-125178646 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032968
 protein coding gene Chr7:129763052-129790423 (+)
A/J MGP_AJ_G0032951
 protein coding gene Chr7:126364853-126392197 (+)
AKR/J MGP_AKRJ_G0032883
 protein coding gene Chr7:129559980-129587376 (+)
BALB/cJ MGP_BALBcJ_G0032956
 protein coding gene Chr7:126013796-126041422 (+)
C3H/HeJ MGP_C3HHeJ_G0032666
 protein coding gene Chr7:129476744-129504122 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033462
 protein coding gene Chr7:134844962-134872322 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030434
 protein coding gene Chr7:127566680-127594390 (+)
CAST/EiJ MGP_CASTEiJ_G0031994
 protein coding gene Chr7:121265154-121296508 (+)
CBA/J MGP_CBAJ_G0032639
 protein coding gene Chr7:139367242-139394582 (+)
DBA/2J MGP_DBA2J_G0032791
 protein coding gene Chr7:124339728-124369406 (+)
FVB/NJ MGP_FVBNJ_G0032744
 protein coding gene Chr7:124174813-124202483 (+)
LP/J MGP_LPJ_G0032885
 protein coding gene Chr7:131237316-131264647 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032776
 protein coding gene Chr7:140610488-140637845 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033482
 protein coding gene Chr7:128558082-128586681 (+)
PWK/PhJ MGP_PWKPhJ_G0031702
 protein coding gene Chr7:117320325-117348227 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031548
 protein coding gene Chr7:115383958-115411589 (+)
WSB/EiJ MGP_WSBEiJ_G0032107
 protein coding gene Chr7:129527800-129555159 (+)



Homology
more
  • Human Ortholog
    IL4R, interleukin 4 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL4R, interleukin 4 receptor
  • Synonyms
    CD124, IL-4RA, IL4RA
  • Links
    NCBI Gene ID: 3566
    neXtProt AC: NX_P24394
    UniProt: P24394

  • Chr Location
    16p12.1; chr16:27313668-27364778 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Il4ra mouse models; 13 with human IL4R associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 8 alleles in 10 genetic backgrounds
    10 phenotypes from multigenic genotypes
    4 images
    332 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit reduced T helper 2 cell response to N. brasiliensis infection. Homozygotes for a null allele also display severe susceptibility to S. mansoni infection, enhanced carcinogen-induced intestinal tumour initiation, and altered control of chronic Leishmania major infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    24
  • cDNA Data
    22
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16190 NCBI Gene Model | MGI Sequence Detail 27204 C57BL/6J ±  kb
    transcript NM_001363983 RefSeq | MGI Sequence Detail 5219 ZRU/MplStud  
    polypeptide P16382 UniProt | EBI | MGI Sequence Detail 810 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 5
      cDNA 22
      Primer pair 7
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11386, MGD-MRK-33035
    References
    more
    • Summaries
      All 441
      Developmental Gene Expression 9
      Diseases 3
      Gene Ontology 14
      Phenotypes 332
    • Earliest
      J:32360 Mosley B, et al., The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell. 1989 Oct 20;59(2):335-48
    • Latest
      J:354880 LaMarche NM, et al., An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature. 2024 Jan;625(7993):166-174
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory