Hspa1l MGI Mouse Gene Detail - MGI:96231 - heat shock protein 1-like

Symbol

Hspa1l
Name

heat shock protein 1-like
Synonyms

70kDa, Hsc70t, Msh5

Feature Type

protein coding gene
IDs

MGI:96231
NCBI Gene: 15482
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:35191679-35198204 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.51 cM
Mapping Data

11 experiments

SNPs within 2kb

1 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96231	protein coding gene	Chr17:35191679-35198261 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023603	protein coding gene	Chr17:35103189-35110089 (+)
A/J	MGP_AJ_G0023563	protein coding gene	Chr17:33947456-33953907 (+)
AKR/J	MGP_AKRJ_G0023531	protein coding gene	Chr17:34412264-34420419 (+)
BALB/cJ	MGP_BALBcJ_G0023569	protein coding gene	Chr17:34076253-34082630 (+)
C3H/HeJ	MGP_C3HHeJ_G0023330	protein coding gene	Chr17:34809512-34817355 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024008	protein coding gene	Chr17:36442162-36451465 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021489	protein coding gene	Chr17:31715715-31722149 (+)
CAST/EiJ	MGP_CASTEiJ_G0022827	protein coding gene	Chr17:34813839-34820513 (+)
CBA/J	MGP_CBAJ_G0023308	protein coding gene	Chr17:37950038-37959224 (+)
DBA/2J	MGP_DBA2J_G0023435	protein coding gene	Chr17:33264140-33271439 (+)
FVB/NJ	MGP_FVBNJ_G0023403	protein coding gene	Chr17:33100538-33107088 (+)
LP/J	MGP_LPJ_G0023513	protein coding gene	Chr17:35433293-35439746 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023425	protein coding gene	Chr17:36884544-36891065 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024053	protein coding gene	Chr17:34622489-34644212 (+)
PWK/PhJ	MGP_PWKPhJ_G0022574	protein coding gene	Chr17:32091716-32098527 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022394	protein coding gene	Chr17:32639192-32650217 (+)
WSB/EiJ	MGP_WSBEiJ_G0022890	protein coding gene	Chr17:34753424-34760601 (+)

Human Ortholog

HSPA1L, heat shock protein family A (Hsp70) member 1 like

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSPA1L, heat shock protein family A (Hsp70) member 1 like
Synonyms

HSP70-1L, HSP70-HOM, HSP70T, hum70t
Links

HGNC:5234

NCBI Gene ID: 3305

neXtProt AC: NX_P34931

UniProt: P34931
Chr Location

6p21.33; chr6:31809619-31815283 (-) GRCh38

MGI Vertebrate Homology

Hspa1l stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: HSPA1L
Gene Tree

Hspa1l

Diseases

5 with human HSPA1L associations

				Human Disease	Mouse Models
				Kawasaki disease IDs Kawasaki disease DOID:13378 EFO:0004246 ICD10CM:M30.3 ICD9CM_2006:446.1 ICD9CM:446.1 MESH:D009080 NCI:C34825 OMIM:611775 UMLS_CUI:C0026691
				major depressive disorder IDs major depressive disorder DOID:1470 DOID:10614 DOID:2240 DOID:2241 DOID:7580 EFO:0003761 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 NCI:C34796 OMIM:608520 OMIM:608691 UMLS_CUI:C0024517 UMLS_CUI:C0154409
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141
				uveitis IDs uveitis DOID:13141 ICD10CM:H20.9 MESH:D014605 NCI:C26909 UMLS_CUI:C0042164

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available

Mice homozygous for a null allele exhibit normal male fertility.

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All GO Annotations

31
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

46
cDNA Data

6
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hspa1l

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS28670.1

Ensembl

ENSMUSG00000007033 (Evidence)
NCBI Gene

15482

			Length	Strain/Species	Flank
genomic	15482	NCBI Gene Model \| MGI Sequence Detail	6526	C57BL/6J	± kb
transcript	NM_013558	RefSeq \| MGI Sequence Detail	2415	ZRU/MplStud
polypeptide	P16627	UniProt \| EBI \| MGI Sequence Detail	641	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008806 heat shock 70 kDa protein 1-like

(term hierarchy)
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR018181 Heat shock protein 70, conserved site

IPR013126 Heat shock protein 70 family

IPR029048 Heat shock protein 70kD, C-terminal domain superfamily

IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
GlyGen

P16627 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 20

Genomic 8

cDNA 7

Primer pair 4

Other 1

Microarray probesets 2

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MGD-MRK-10942

Summaries

All 59

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 5
Earliest

J:10291 Matsumoto M, et al., Cloning of a hsp70-related gene expressed in mouse spermatids. Biochem Biophys Res Commun. 1990 Jan 15;166(1):43-9
Latest

J:342696 Nakatsuka A, et al., A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease. Commun Biol. 2021 Mar 19;4(1):373

TSS for Hspa1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144146	Chr17:35191663-35191681 (+)	-7 bp
Tssr144147	Chr17:35191684-35191705 (+)	16 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24