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Il7r Gene Detail
Summary
  • Symbol
    Il7r
  • Name
    interleukin 7 receptor
  • Synonyms
    CD127, IL-7Ralpha, IL-7 receptor alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:96562
    NCBI Gene: 16197
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:9505874-9530262 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 4.16 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    745 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96562
 protein coding gene Chr15:9505874-9530270 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021716
 protein coding gene Chr15:6597355-6622733 (-)
A/J MGP_AJ_G0021676
 protein coding gene Chr15:6422479-6447746 (-)
AKR/J MGP_AKRJ_G0021654
 protein coding gene Chr15:6583280-6606796 (-)
BALB/cJ MGP_BALBcJ_G0021683
 protein coding gene Chr15:6340976-6367879 (-)
C3H/HeJ MGP_C3HHeJ_G0021459
 protein coding gene Chr15:6524260-6554253 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022122
 protein coding gene Chr15:6839450-6869294 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019659
 protein coding gene Chr15:5940975-5964569 (-)
CAST/EiJ MGP_CASTEiJ_G0020975
 protein coding gene Chr15:6599078-6622584 (-)
CBA/J MGP_CBAJ_G0021428
 protein coding gene Chr15:7000950-7027540 (-)
DBA/2J MGP_DBA2J_G0021552
 protein coding gene Chr15:6306854-6331479 (-)
FVB/NJ MGP_FVBNJ_G0021530
 protein coding gene Chr15:6196927-6220560 (-)
LP/J MGP_LPJ_G0021620
 protein coding gene Chr15:6517027-6549976 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021555
 protein coding gene Chr15:7217986-7252275 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022145
 protein coding gene Chr15:6560062-6583705 (-)
PWK/PhJ MGP_PWKPhJ_G0020718
 protein coding gene Chr15:6444091-6467900 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020556
 protein coding gene Chr15:6502334-6525719 (-)
WSB/EiJ MGP_WSBEiJ_G0021031
 protein coding gene Chr15:6562808-6587374 (-)



Homology
more
  • Human Ortholog
    IL7R, interleukin 7 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL7R, interleukin 7 receptor
  • Synonyms
    CD127, CDW127, IL7RA, IL-7R-alpha, IL-7Ralpha, IL7Ralpha, ILRA, IMD104, lnc-IL7R, sIL-7R
  • Links
    NCBI Gene ID: 3575
    neXtProt AC: NX_P16871
    UniProt: P16871

  • Chr Location
    5p13.2; chr5:35852695-35879603 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human IL7R associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 7 alleles in 10 genetic backgrounds
    4 phenotypes from multigenic genotypes
    251 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations cause arrested T and B cell differentiation and severely reduced thymus and spleen cellularity. Mice homozygous for a knock-in allele show partial rescue of T cell numbers during late thymus development, and impaired CD8 T cell memory and CD4 T cell primary responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    19
  • cDNA Data
    144
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003882 Ensembl Gene Model | MGI Sequence Detail 24389 C57BL/6J ±  kb
    transcript ENSMUST00000003981 Ensembl | MGI Sequence Detail 3540 Not Applicable  
    polypeptide ENSMUSP00000003981 Ensembl | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      Genomic 4
      cDNA 147
      Primer pair 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11395
    References
    more
    • Summaries
      All 383
      Developmental Gene Expression 25
      Gene Ontology 12
      Phenotypes 251
    • Earliest
      J:10373 Goodwin RG, et al., Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. 1990 Mar 23;60(6):941-51
    • Latest
      J:355331 Mao Y, et al., Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory