Eno1 MGI Mouse Gene Detail - MGI:95393 - enolase 1, alpha non-neuron

Symbol

Eno1
Name

enolase 1, alpha non-neuron
Synonyms

2-phospho-D-glycerate hydrolase, alpha-enolase, c-Myc promoter binding protein, Eno-1, MBP-1

Feature Type

protein coding gene
IDs

MGI:95393
NCBI Gene: 13806
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr4:150321178-150333336 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 81.24 cM
Mapping Data

8 experiments

SNPs within 2kb

142 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95393	protein coding gene	Chr4:150321165-150333336 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029153	protein coding gene	Chr4:154187546-154201440 (+)
A/J	MGP_AJ_G0029118	protein coding gene	Chr4:147720595-147733337 (+)
AKR/J	MGP_AKRJ_G0029066	protein coding gene	Chr4:151776648-151789197 (+)
BALB/cJ	MGP_BALBcJ_G0029134	protein coding gene	Chr4:148219109-148231392 (+)
C3H/HeJ	MGP_C3HHeJ_G0028855	protein coding gene	Chr4:152317640-152330219 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029583	protein coding gene	Chr4:159732583-159748326 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026829	protein coding gene	Chr4:140129922-140142194 (+)
CAST/EiJ	MGP_CASTEiJ_G0028268	protein coding gene	Chr4:149582219-149597493 (+)
CBA/J	MGP_CBAJ_G0028817	protein coding gene	Chr4:164439922-164470290 (+)
DBA/2J	MGP_DBA2J_G0028966	protein coding gene	Chr4:147811016-147822932 (+)
FVB/NJ	MGP_FVBNJ_G0028930	protein coding gene	Chr4:146941907-146955903 (+)
LP/J	MGP_LPJ_G0029056	protein coding gene	Chr4:154109655-154130557 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028957	protein coding gene	Chr4:167587980-167599978 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029615	protein coding gene	Chr4:152281893-152295389 (+)
PWK/PhJ	MGP_PWKPhJ_G0027988	protein coding gene	Chr4:143837021-143850189 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027822	protein coding gene	Chr4:146542799-146554869 (+)
WSB/EiJ	MGP_WSBEiJ_G0028348	protein coding gene	Chr4:152419942-152436682 (+)

Human Ortholog

ENO1, enolase 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ENO1, enolase 1
Synonyms

ENO1-IT1, ENO1L1, HEL-S-17, MPB1, NNE, PPH
Links

HGNC:3350

NCBI Gene ID: 2023

neXtProt AC: NX_P06733

UniProt: P06733
Chr Location

1p36.23; chr1:8861000-8879190 (-) GRCh38

MGI Vertebrate Homology

Eno1 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: ENO1
Protein SuperFamily

Enolase
Gene Tree

Eno1

Diseases

1 with human ENO1 associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

80
Endonuclease-mediated

3
Gene trapped

75
Targeted

2
Genomic Mutations

1 involving Eno1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous animals exhibit growth arrest and embryonic lethality at approximately E6.5.

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All GO Annotations

59
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

996
Tissues

165
cDNA Data

29
Literature Summary

30

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eno1

ZFIN eno1a

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All Sequences

188
RefSeq

18
UniProt

1
CCDS

CCDS18971.1

Ensembl

ENSMUSG00000063524 (Evidence)
NCBI Gene

13806

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063524	Ensembl Gene Model \| MGI Sequence Detail	12159	C57BL/6J	± kb
transcript	ENSMUST00000080926	Ensembl \| MGI Sequence Detail	2027	Not Applicable
polypeptide	ENSMUSP00000079727	Ensembl \| MGI Sequence Detail	434	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007080 alpha-enolase

(term hierarchy)
GlyGen

P17182 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 38

Genomic 1

cDNA 33

Primer pair 2

Other 2

Microarray probesets 10

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MGD-MRK-9503, MGD-MRK-9506, MGI:2143710

Summaries

All 104

Developmental Gene Expression 30

Gene Ontology 16

Phenotypes 12
Earliest

J:5856 D'Ancona GG, et al., Assignment of the gene for enolase to mouse chromosome 4 using somatic cell hybrids. Cytogenet Cell Genet. 1977;19(1):1-6
Latest

J:352089 Grammer C, et al., Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. iScience. 2024 Jul 19;27(7):110258

TSS for Eno1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40390	Chr4:150321142-150321224 (+)	5 bp
Tssr40391	Chr4:150321227-150321237 (+)	54 bp
Tssr40392	Chr4:150321246-150321253 (+)	72 bp
Tssr40393	Chr4:150321259-150321266 (+)	85 bp
Tssr40394	Chr4:150321273-150321276 (+)	97 bp
Tssr40395	Chr4:150321659-150321665 (+)	484 bp
Tssr40396	Chr4:150321668-150321696 (+)	504 bp
Tssr40397	Chr4:150321760-150321799 (+)	602 bp
Tssr40398	Chr4:150322151-150322162 (+)	979 bp
Tssr40399	Chr4:150322180-150322194 (+)	1,009 bp
Tssr40400	Chr4:150325377-150325381 (+)	4,201 bp
Tssr40401	Chr4:150333046-150333054 (+)	11,872 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24