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Ppia Gene Detail
Summary
  • Symbol
    Ppia
  • Name
    peptidylprolyl isomerase A
  • Synonyms
    Cphn, cyclophilin A, CyP-18, CypA
  • Feature Type
    protein coding gene
  • IDs
    MGI:97749
    NCBI Gene: 268373
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:6365867-6369817 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 3.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97749
 protein coding gene Chr11:6365443-6369817 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018022
 protein coding gene Chr11:3528945-3533177 (+)
A/J MGP_AJ_G0017995
 protein coding gene Chr11:3382354-3386649 (+)
AKR/J MGP_AKRJ_G0017959
 protein coding gene Chr11:3549000-3552948 (+)
BALB/cJ MGP_BALBcJ_G0017963
 protein coding gene Chr11:3389249-3393766 (+)
C3H/HeJ MGP_C3HHeJ_G0017776
 protein coding gene Chr11:3422923-3427398 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018415
 protein coding gene Chr11:3634055-3638249 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016073
 protein coding gene Chr11:3273308-3276720 (+)
CAST/EiJ MGP_CASTEiJ_G0017338
 protein coding gene Chr11:3415028-3419292 (+)
CBA/J MGP_CBAJ_G0017751
 protein coding gene Chr11:4041059-4049203 (+)
DBA/2J MGP_DBA2J_G0017861
 protein coding gene Chr11:3294250-3299516 (+)
FVB/NJ MGP_FVBNJ_G0017853
 protein coding gene Chr11:3318437-3322686 (+)
LP/J MGP_LPJ_G0017932
 protein coding gene Chr11:3604885-3610511 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017879
 protein coding gene Chr11:3588928-3593198 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018455
 protein coding gene Chr11:3570783-3575964 (+)
PWK/PhJ MGP_PWKPhJ_G0017118
 protein coding gene Chr11:3327304-3331589 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016915
 protein coding gene Chr11:3508336-3514260 (+)
WSB/EiJ MGP_WSBEiJ_G0017392
 protein coding gene Chr11:3390033-3394760 (+)



Homology
more
  • Human Ortholog
    PPIA, peptidylprolyl isomerase A
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPIA, peptidylprolyl isomerase A
  • Synonyms
    CYPA, CYPH, HEL-S-69p
  • Links
    NCBI Gene ID: 5478
    neXtProt AC: NX_P62937
    UniProt: P62937

  • Chr Location
    7p13; chr7:44796680-44824564 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PPIA associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 2 alleles in 3 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene tend to develop blepharitis (about 30% of mice) as well as inflammation in other organs. Some background dependent embryonic lethality occurs but adults are robust and live normal life spans.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    36
  • cDNA Data
    35
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268373 NCBI Gene Model | MGI Sequence Detail 3951 C57BL/6J ±  kb
    transcript NM_008907 RefSeq | MGI Sequence Detail 746 ZRU/MplStud  
    polypeptide P17742 UniProt | EBI | MGI Sequence Detail 164 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013075 peptidyl-prolyl cis-trans isomerase A
      (term hierarchy)
    • PDB
      6FK1
    • EC
      5.2.1.8
    • InterPro Domains
      IPR029000 Cyclophilin-like domain superfamily
      IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
      IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
      IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    • GlyGen
      P17742 3 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 36
      Primer pair 9

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-13591, MGD-MRK-2108
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 24
      Gene Ontology 12
      Phenotypes 41
    • Earliest
      J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
    • Latest
      J:351016 Stauffer WT, et al., Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model. PLoS One. 2024;19(3):e0298211
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory