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H2-Eb1 Gene Detail
Summary
  • Symbol
    H2-Eb1
  • Name
    histocompatibility 2, class II antigen E beta
  • Synonyms
    H-2Eb, Ia-4, Ia4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95901
    NCBI Gene: 14969
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:34524841-34535648 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    7
  • RFLP
    31
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95901
 protein coding gene Chr17:34524841-34535648 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023569
 protein coding gene Chr17:34313186-34324124 (+)
A/J MGP_AJ_G0023531
 protein coding gene Chr17:33145696-33157600 (+)
AKR/J MGP_AKRJ_G0023496
 protein coding gene Chr17:33534924-33547095 (+)
BALB/cJ MGP_BALBcJ_G0023535
 protein coding gene Chr17:33307950-33318231 (+)
C3H/HeJ MGP_C3HHeJ_G0023295
 protein coding gene Chr17:33888733-33904689 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023975
 protein coding gene Chr17:35598911-35610672 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021454
 protein coding gene Chr17:31114512-31124399 (+)
CAST/EiJ MGP_CASTEiJ_G0022795
 protein coding gene Chr17:33980470-33991715 (+)
CBA/J MGP_CBAJ_G0023273
 protein coding gene Chr17:37067676-37077735 (+)
DBA/2J MGP_DBA2J_G0023402
 protein coding gene Chr17:32492927-32503052 (+)
FVB/NJ MGP_FVBNJ_G0023368
 protein coding gene Chr17:32348993-32360137 (+)
LP/J MGP_LPJ_G0023479
 protein coding gene Chr17:34571512-34582890 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023391
 protein coding gene Chr17:36033942-36047880 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024018
 protein coding gene Chr17:33867386-33878261 (+)
PWK/PhJ MGP_PWKPhJ_G0022545
 protein coding gene Chr17:31430518-31440751 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022360
 protein coding gene Chr17:31828093-31841005 (+)
WSB/EiJ MGP_WSBEiJ_G0022856
 protein coding gene Chr17:33902984-33913396 (+)



Homology
more
  • Human Ortholog
    HLA-DRB1, major histocompatibility complex, class II, DR beta 1
  • Vertebrate Orthologs
    11
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-DRB1, major histocompatibility complex, class II, DR beta 1
  • Synonyms
    DRB1, HLA-DR1B, HLA-DRB, SS1
  • Links
    NCBI Gene ID: 3123
    neXtProt AC: NX_P01911
    UniProt: P01911

  • Chr Location
    6p21.32; chr6:32577902-32589848 (-)  GRCh38
  • Human Ortholog
    HLA-DRB3, major histocompatibility complex, class II, DR beta 3
  • Synonyms
    DRB3, HLA-DPB1, HLA-DR1B, HLA-DR3B, HLA-DRB3*
  • Links
    NCBI Gene ID: 3125
    neXtProt AC: NX_P79483
    UniProt: P79483

  • Chr Location
    6p21.3
  • Human Ortholog
    HLA-DRB4, major histocompatibility complex, class II, DR beta 4
  • Synonyms
    DR4, DRB4, HLA-DR4B, HLA-DRB, HLA-DRB4*
  • Links
    NCBI Gene ID: 3126
    neXtProt AC: NX_P13762
    UniProt: P13762

  • Chr Location
    6p21.3
  • Human Ortholog
    HLA-DRB5, major histocompatibility complex, class II, DR beta 5
  • Synonyms
    DRB5, HLA-DRB5*
  • Links
    NCBI Gene ID: 3127
    neXtProt AC: NX_Q30154
    UniProt: Q30154

  • Chr Location
    6p21.32; chr6:32517353-32530287 (-)  GRCh38
Human Diseases
more
  • Diseases
    93 with human HLA-DRB1,HLA-DRB3,HLA-DRB4,HLA-DRB5 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    232 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    151
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14969 NCBI Gene Model | MGI Sequence Detail 10808 C57BL/6J ±  kb
    transcript NM_010382 RefSeq | MGI Sequence Detail 1669 ZRU/MplStud  
    polypeptide P18469 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 200
      Genomic 37
      cDNA 155
      Primer pair 6
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10384, MGD-MRK-10497, MGD-MRK-11047, MGD-MRK-11052
    References
    more
    • Summaries
      All 306
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 232
    • Earliest
      J:5682 Murphy DB, et al., A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. J Exp Med. 1976 Sep 1;144(3):699-712
    • Latest
      J:350703 Sharma P, et al., The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity. Science. 2024 Feb 16;383(6684):eadg0564
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory