Cr2 MGI Mouse Gene Detail - MGI:88489

Symbol

Cr2
Name

complement receptor 2
Synonyms

C3DR, CD21, CD35, Cr-1, Cr1, Cr-2

Feature Type

protein coding gene
IDs

MGI:88489
NCBI Gene: 12902
Alliance

gene page
Transcription Start Sites

5 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr1:194819119-194859024 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 98.44 cM
Mapping Data

12 experiments

SNPs within 2kb

535 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88489	protein coding gene	Chr1:194819119-194859096 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016969	protein coding gene	Chr1:202319950-202361696 (-)
A/J	MGP_AJ_G0016948	protein coding gene	Chr1:194009170-194050263 (-)
AKR/J	MGP_AKRJ_G0016913	protein coding gene	Chr1:199750634-199790244 (-)
BALB/cJ	MGP_BALBcJ_G0016906	protein coding gene	Chr1:194709362-194755191 (-)
C3H/HeJ	MGP_C3HHeJ_G0016730	protein coding gene	Chr1:200643133-200694855 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017369	protein coding gene	Chr1:208691087-208732026 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015076	protein coding gene	Chr1:185402204-185440865 (-)
CAST/EiJ	MGP_CASTEiJ_G0016313	protein coding gene	Chr1:200201625-200248704 (-)
CBA/J	MGP_CBAJ_G0016704	protein coding gene	Chr1:216387468-216430616 (-)
DBA/2J	MGP_DBA2J_G0016810	protein coding gene	Chr1:192728921-192771485 (-)
FVB/NJ	MGP_FVBNJ_G0016806	protein coding gene	Chr1:190822077-190863084 (-)
LP/J	MGP_LPJ_G0016885	protein coding gene	Chr1:203449937-203494845 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016838	protein coding gene	Chr1:223047359-223094913 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017406	protein coding gene	Chr1:199595238-199636575 (-)
PWK/PhJ	MGP_PWKPhJ_G0016100	protein coding gene	Chr1:192038104-192081020 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015876	protein coding gene	Chr1:198643653-198685024 (-)
WSB/EiJ	MGP_WSBEiJ_G0016375	protein coding gene	Chr1:199878547-199927507 (-)

Human Ortholog

CR2, complement C3d receptor 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CR2, complement C3d receptor 2
Synonyms

C3DR, CD21, CR, CVID7, SLEB9
Links

HGNC:2336

NCBI Gene ID: 1380

neXtProt AC: NX_P20023

UniProt: P20023
Chr Location

1q32.2; chr1:207453024-207489895 (+) GRCh38

MGI Vertebrate Homology

Cr2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CR2
Gene Tree

Cr2

Diseases

3 with human CR2 associations

				Human Disease	Mouse Models
				common variable immunodeficiency 7 IDs common variable immunodeficiency 7 DOID:0081150 OMIM:614699
				nasopharynx carcinoma IDs nasopharynx carcinoma DOID:9261 DOID:8813 DOID:8814 DOID:9057 DOID:9144 DOID:9197 DOID:9229 ICD10CM:C11 ICD10CM:C11.0 ICD10CM:C11.1 ICD10CM:C11.2 ICD10CM:C11.3 ICD9CM:147 ICD9CM:147.0 ICD9CM:147.1 ICD9CM:147.2 ICD9CM:147.3 ICD9CM:147.9 MESH:D009303 NCI:C9321 OMIM:161550 OMIM:607107 ORDO:150 UMLS_CUI:C0153392 UMLS_CUI:C0153393 UMLS_CUI:C0153394 UMLS_CUI:C0153395 UMLS_CUI:C0153396 UMLS_CUI:C0238301
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

37 phenotypes from 7 alleles in 10 genetic backgrounds
2 phenotypes from multigenic genotypes
94 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

1
Endonuclease-mediated

5
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

84 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation.

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All GO Annotations

27
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

35
cDNA Data

36
Literature Summary

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

74
RefSeq

13
UniProt

9
CCDS

CCDS15642.1, CCDS87949.1

Ensembl

ENSMUSG00000026616 (Evidence)
NCBI Gene

12902

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026616	Ensembl Gene Model \| MGI Sequence Detail	39906	C57BL/6J	± kb
transcript	ENSMUST00000210219	Ensembl \| MGI Sequence Detail	4227	Not Applicable
polypeptide	ENSMUSP00000147804	Ensembl \| MGI Sequence Detail	1408	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000001338 complement receptor type 2

(term hierarchy)
InterPro Domains

IPR050350 Complement & Cell Adhesion Regulators

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily
GlyGen

P19070 17 sites

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All nucleic 52

Genomic 12

cDNA 37

Primer pair 2

Other 1

Microarray probesets 4

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MGD-MRK-2122, MGD-MRK-2123, MGD-MRK-2124, MGD-MRK-2125

Summaries

All 186

Developmental Gene Expression 8

Gene Ontology 13

Phenotypes 94
Earliest

J:7312 Bubbers JE, Identification and linkage analyses of a gene, Rcs-1, suppressing spontaneous SJL/J lymphoma expression. J Natl Cancer Inst. 1984 Feb;72(2):441-6
Latest

J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10

TSS for Cr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15877	Chr1:194859080-194859091 (-)	-62 bp
Tssr15876	Chr1:194859015-194859033 (-)	0 bp
Tssr385	Chr1:194858995-194859002 (-)	25 bp
Tssr384	Chr1:194858967-194858990 (-)	45 bp
Tssr15875	Chr1:194858945-194858954 (-)	74 bp

Cr2 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Sle1c	Chr1, 94.73 cM	Chr1:188594514-189303617	J:73128	The NZM2410 interval contains the Sle1 QTLs and originated from an (NZB x NZW) cross. In order to construct congenic strains of mice which contain selected Sle loci, NZM2410 were backcrossed to C57BL/6J mice six successive times, screening progeny withPCR or SSR markers for specific genomic intervals. One such locus Sle1c resided in an interval of mouse Chromosome 1 that contained Cr2 which is a possible candidate for Sle1c. There were at least 16 nucleotide sequence differences between NZW and C57BL/6J at the Cr2 locus. The authors provided evidence suggesting that Cr2 is the disease susceptibility gene corresponding to the Sle1c QTL.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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