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Hspa5 Gene Detail
Summary
  • Symbol
    Hspa5
  • Name
    heat shock protein 5
  • Synonyms
    78kDa, baffled, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, mBiP, Sez7, XAP-1 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:95835
    NCBI Gene: 14828
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:34662102-34666541 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.94 cM
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95835
 protein coding gene Chr2:34661982-34667559 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025640
 protein coding gene Chr2:33377615-33383192 (+)
A/J MGP_AJ_G0025617
 protein coding gene Chr2:31960650-31966227 (+)
AKR/J MGP_AKRJ_G0025587
 protein coding gene Chr2:33088766-33094343 (+)
BALB/cJ MGP_BALBcJ_G0025614
 protein coding gene Chr2:32070642-32076219 (+)
C3H/HeJ MGP_C3HHeJ_G0025374
 protein coding gene Chr2:32979212-32984789 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026058
 protein coding gene Chr2:34346327-34353321 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023467
 protein coding gene Chr2:30658585-30664087 (+)
CAST/EiJ MGP_CASTEiJ_G0024836
 protein coding gene Chr2:32973973-32982185 (+)
CBA/J MGP_CBAJ_G0025352
 protein coding gene Chr2:35677039-35682616 (+)
DBA/2J MGP_DBA2J_G0025485
 protein coding gene Chr2:31732997-31738574 (+)
FVB/NJ MGP_FVBNJ_G0025447
 protein coding gene Chr2:31624019-31629596 (+)
LP/J MGP_LPJ_G0025571
 protein coding gene Chr2:33294941-33300518 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025478
 protein coding gene Chr2:35194028-35199605 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026116
 protein coding gene Chr2:32980000-32985603 (+)
PWK/PhJ MGP_PWKPhJ_G0024584
 protein coding gene Chr2:31645336-31651027 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024384
 protein coding gene Chr2:33139527-33144953 (+)
WSB/EiJ MGP_WSBEiJ_G0024905
 protein coding gene Chr2:33154992-33160572 (+)



Homology
more
  • Human Ortholog
    HSPA5, heat shock protein family A (Hsp70) member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA5, heat shock protein family A (Hsp70) member 5
  • Synonyms
    BIP, GRP78, HEL-S-89n
  • Links
    NCBI Gene ID: 3309
    neXtProt AC: NX_P11021
    UniProt: P11021

  • Chr Location
    9q33.3; chr9:125234853-125241382 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HSPA5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 5 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous embryos die around implantation. Neonates homozygous for a knock-in allele die of respiratory failure. Mice homozygous for an ENU-induced mutation exhibit abnormal thalamocortical axon patterning, small kidneys, cleft palate, respiratory distress, and postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    101
  • GO References
    47
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1157
  • Tissues
    214
  • cDNA Data
    35
  • Literature Summary
    126
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14828 NCBI Gene Model | MGI Sequence Detail 4440 C57BL/6J ±  kb
    transcript NM_022310 RefSeq | MGI Sequence Detail 2616 ZRU/MplStud  
    polypeptide P20029 UniProt | EBI | MGI Sequence Detail 655 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000008810 endoplasmic reticulum chaperone BiP
      (term hierarchy)
    • EC
      3.6.4.10
    • InterPro Domains
      IPR043129 ATPase, nucleotide binding domain
      IPR042050 Endoplasmic reticulum chaperone BIP, nucleotide-binding domain
      IPR018181 Heat shock protein 70, conserved site
      IPR013126 Heat shock protein 70 family
      IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
      IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
    • GlyGen
      P20029 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 1
      cDNA 40
      Primer pair 19
      Other 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10275, MGD-MRK-10943, MGD-MRK-1560, MGD-MRK-34244, MGD-MRK-35815, MGI:106550, MGI:107349, MGI:2139125, MGI:2139181, MGI:4889058
    References
    more
    • Summaries
      All 332
      Developmental Gene Expression 126
      Gene Ontology 47
      Phenotypes 52
    • Earliest
      J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
    • Latest
      J:350484 Neupane S, et al., Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues. J Biol Chem. 2024 Jun 4;300(7):107445
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    10/22/2024
    MGI 6.24     		The Jackson Laboratory