Tpm3 MGI Mouse Gene Detail - MGI:1890149

Symbol

Tpm3
Name

tropomyosin 3, gamma
Synonyms

gamma-TM, hTM30nm, hTMnm, skalphaTM.2, Tm5NM, Tpm-5, Tpm5, Trop-5

Feature Type

protein coding gene
IDs

MGI:1890149
NCBI Gene: 59069
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:89979958-90008209 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.20 cM
Mapping Data

1 experiment

SNPs within 2kb

702 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890149	protein coding gene	Chr3:89979956-90008209 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027453	protein coding gene	Chr3:90338685-90366012 (+)
A/J	MGP_AJ_G0027417	protein coding gene	Chr3:87343905-87371277 (+)
AKR/J	MGP_AKRJ_G0027381	protein coding gene	Chr3:89481116-89513823 (+)
BALB/cJ	MGP_BALBcJ_G0027426	protein coding gene	Chr3:87310942-87339425 (+)
C3H/HeJ	MGP_C3HHeJ_G0027168	protein coding gene	Chr3:89655234-89689436 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027872	protein coding gene	Chr3:93726367-93767311 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025224	protein coding gene	Chr3:82838909-82867972 (+)
CAST/EiJ	MGP_CASTEiJ_G0026614	protein coding gene	Chr3:90026908-90054937 (+)
CBA/J	MGP_CBAJ_G0027142	protein coding gene	Chr3:96972775-97004016 (+)
DBA/2J	MGP_DBA2J_G0027280	protein coding gene	Chr3:86717302-86743270 (+)
FVB/NJ	MGP_FVBNJ_G0027248	protein coding gene	Chr3:85051616-85080780 (+)
LP/J	MGP_LPJ_G0027389	protein coding gene	Chr3:91410836-91450934 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027268	protein coding gene	Chr3:103152887-103182270 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027931	protein coding gene	Chr3:89230842-89262141 (+)
PWK/PhJ	MGP_PWKPhJ_G0026348	protein coding gene	Chr3:86606292-86635466 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026167	protein coding gene	Chr3:88401831-88435320 (+)
WSB/EiJ	MGP_WSBEiJ_G0026696	protein coding gene	Chr3:89623438-89651447 (+)

Human Ortholog

TPM3, tropomyosin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TPM3, tropomyosin 3
Synonyms

CAPM1, CFTD, CMYO4A, CMYO4B, CMYP4A, CMYP4B, HEL-189, HEL-S-82p, hscp30, NEM1, OK/SW-cl.5, TM3, TM30, TM30nm, TM-5, TM5, TPM3nu, TPMsk3, TRK
Links

HGNC:12012

NCBI Gene ID: 7170

neXtProt AC: NX_P06753

UniProt: P06753
Chr Location

1q21.3; chr1:154155308-154194648 (-) GRCh38

MGI Vertebrate Homology

Tpm3 stringent orthology
1 human;1 mouse;3 zebrafish
HCOP

vertebrate homology predictions: TPM3
Gene Tree

Tpm3

Diseases

2 with human TPM3 associations

				Human Disease	Mouse Models
				congenital myopathy 4A IDs congenital myopathy 4A DOID:0080102 OMIM:255310
				nemaline myopathy 1 IDs nemaline myopathy 1 DOID:0110926 MESH:C538348 OMIM:609284

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 4 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

66
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

57
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Tpm3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene results in early embryonic death, prior to blastocyst formation. Mice homozygous for a targeted allele lacking exon 9 exhibit dysmorphic T-tubules and contraction in skeletal muscles.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

39
Literature Summary

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase MGC76092

ZFIN tpm3

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All Sequences

134
RefSeq

29
UniProt

11
CCDS

CCDS38499.2, CCDS57223.1, CCDS79961.1, CCDS89659.1

Ensembl

ENSMUSG00000027940 (Evidence)
NCBI Gene

59069

			Length	Strain/Species	Flank
genomic	59069	NCBI Gene Model \| MGI Sequence Detail	28252	C57BL/6J	± kb
transcript	NM_001271764	RefSeq \| MGI Sequence Detail	2335	C57BL/6
polypeptide	P21107	UniProt \| EBI \| MGI Sequence Detail	285	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000016581 tropomyosin alpha-3 chain

(term hierarchy)
InterPro Domains

IPR014751 DNA repair protein XRCC4-like, C-terminal

IPR000533 Tropomyosin
GlyGen

P21107 1 site, 1 O-linked glycan (1 site)

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All nucleic 40

cDNA 39

Other 1

Microarray probesets 10

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MGD-MRK-15204, MGD-MRK-15207, MGD-MRK-15242, MGI:98811

Summaries

All 60

Developmental Gene Expression 6

Diseases 1

Gene Ontology 7

Phenotypes 19
Earliest

J:20239 MacLeod AR, et al., Human hTM alpha gene: expression in muscle and nonmuscle tissue. Mol Cell Biol. 1988 Jan;8(1):433-40
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tpm3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30154	Chr3:89979948-89979964 (+)	-2 bp
Tssr30155	Chr3:89986831-89986844 (+)	6,880 bp
Tssr30156	Chr3:89986853-89986872 (+)	6,905 bp
Tssr30157	Chr3:89986926-89986971 (+)	6,991 bp
Tssr30158	Chr3:89987792-89987805 (+)	7,841 bp
Tssr30159	Chr3:89993649-89993660 (+)	13,697 bp
Tssr30160	Chr3:89994722-89994746 (+)	14,776 bp
Tssr30161	Chr3:89995400-89995404 (+)	15,444 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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