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Bmp4 Gene Detail
Summary
  • Symbol
    Bmp4
  • Name
    bone morphogenetic protein 4
  • Synonyms
    Bmp2b, Bmp2b-1, Bmp2b1, Bmp-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88180
    NCBI Gene: 12159
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:46620982-46628126 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 23.95 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88180
 protein coding gene Chr14:46620977-46628126 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021212
 protein coding gene Chr14:40049812-40058693 (-)
A/J MGP_AJ_G0021159
 protein coding gene Chr14:38862241-38869377 (-)
AKR/J MGP_AKRJ_G0021137
 protein coding gene Chr14:40371788-40381074 (-)
BALB/cJ MGP_BALBcJ_G0021163
 protein coding gene Chr14:38916652-38924054 (-)
C3H/HeJ MGP_C3HHeJ_G0020946
 protein coding gene Chr14:40160734-40169701 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021597
 protein coding gene Chr14:41791348-41803352 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019156
 protein coding gene Chr14:38241791-38248800 (-)
CAST/EiJ MGP_CASTEiJ_G0020471
 protein coding gene Chr14:37280999-37288520 (-)
CBA/J MGP_CBAJ_G0020912
 protein coding gene Chr14:43114256-43125101 (-)
DBA/2J MGP_DBA2J_G0021035
 protein coding gene Chr14:38768561-38776002 (-)
FVB/NJ MGP_FVBNJ_G0021020
 protein coding gene Chr14:38508353-38515470 (-)
LP/J MGP_LPJ_G0021105
 protein coding gene Chr14:40334504-40341630 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021045
 protein coding gene Chr14:42514032-42522150 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021630
 protein coding gene Chr14:39923424-39931484 (-)
PWK/PhJ MGP_PWKPhJ_G0020220
 protein coding gene Chr14:35631800-35639670 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020044
 protein coding gene Chr14:36068423-36076035 (-)
WSB/EiJ MGP_WSBEiJ_G0020527
 protein coding gene Chr14:40022667-40032540 (-)



Homology
more
  • Human Ortholog
    BMP4, bone morphogenetic protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP4, bone morphogenetic protein 4
  • Synonyms
    BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
  • Links
    NCBI Gene ID: 652
    neXtProt AC: NX_P12644
    UniProt: P12644

  • Chr Location
    14q22.2; chr14:53949736-53958761 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with Bmp4 mouse models; 11 with human BMP4 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    256 phenotypes from 16 alleles in 37 genetic backgrounds
    122 phenotypes from multigenic genotypes
    10 images
    188 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutants have wide ranging effects, including embryonic lethality, aberrant mesoderm differentation, developmental retardation and disorganized posterior structures; heterozygous null mutants display anomalies of the kidney and urinary tract; other targeted mutants display failure of lens induction and lack primordial germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    314
  • GO References
    101
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    3383
  • Tissues
    1117
  • cDNA Data
    60
  • Literature Summary
    1219
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12159 NCBI Gene Model | MGI Sequence Detail 7145 C57BL/6J ±  kb
    transcript NM_007554 RefSeq | MGI Sequence Detail 2059 ZRU/MplStud  
    polypeptide P21275 UniProt | EBI | MGI Sequence Detail 408 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 283
      Genomic 1
      cDNA 78
      Primer pair 57
      Other 147

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1596, MGD-MRK-1597, MGD-MRK-1600, MGD-MRK-1602
    References
    more
    • Summaries
      All 1520
      Developmental Gene Expression 1219
      Diseases 6
      Gene Ontology 101
      Phenotypes 188
    • Earliest
      J:15319 Wozney JM, et al., Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16;242(4885):1528-34
    • Latest
      J:354051 Kagoshima H, et al., EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development. J Neurosci. 2024 Feb 14;44(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory