Ang MGI Mouse Gene Detail - MGI:88022 - angiogenin, ribonuclease, RNase A family, 5

Symbol

Ang
Name

angiogenin, ribonuclease, RNase A family, 5
Synonyms

Ang1, Rnase5a

Feature Type

protein coding gene
IDs

MGI:88022
NCBI Gene: 11727
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:51328607-51339462 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.37 cM, cytoband B-C1
Mapping Data

9 experiments

SNPs within 2kb

489 from dbSNP Build 142
Strain Annotations

15

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88022	protein coding gene	Chr14:51328607-51339466 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021271	protein coding gene	Chr14:45054548-45069511 (+)
A/J	MGP_AJ_G0021225	protein coding gene	Chr14:43704153-43715912 (+)
AKR/J	MGP_AKRJ_G0021201	protein coding gene	Chr14:45353901-45364930 (+)
BALB/cJ	MGP_BALBcJ_G0021228	protein coding gene	Chr14:43824801-43840884 (+)
C3H/HeJ	MGP_C3HHeJ_G0021010	protein coding gene	Chr14:45175392-45186239 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021665	protein coding gene	Chr14:46906077-46918559 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0020534	protein coding gene	Chr14:42241074-42251873 (+)
CBA/J	MGP_CBAJ_G0020977	protein coding gene	Chr14:48364052-48374885 (+)
DBA/2J	MGP_DBA2J_G0021101	protein coding gene	Chr14:43598590-43609421 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0021169	protein coding gene	Chr14:45348179-45360336 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0021694	protein coding gene	Chr14:44838691-44849601 (+)
PWK/PhJ	MGP_PWKPhJ_G0020284	protein coding gene	Chr14:40499254-40741035 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020109	protein coding gene	Chr14:41007490-41246378 (+)
WSB/EiJ	MGP_WSBEiJ_G0020587	protein coding gene	Chr14:45036910-45048908 (+)

Human Ortholog

ANG, angiogenin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANG, angiogenin
Synonyms

ALS9, HEL168, RAA1, RNASE4, RNASE5
Links

HGNC:483

NCBI Gene ID: 283

neXtProt AC: NX_P03950

UniProt: P03950
Chr Location

14q11.2; chr14:20684177-20698971 (+) GRCh38

MGI Vertebrate Homology

Ang stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANG
Gene Tree

Ang

Diseases

6 with human ANG associations

				Human Disease	Mouse Models
				amyotrophic lateral sclerosis IDs amyotrophic lateral sclerosis DOID:332 ICD10CM:G12.21 ICD9CM:335.20 KEGG:05014 MESH:D000690 NCI:C34373 OMIM:PS105400 ORDO:803 UMLS_CUI:C0002736
				amyotrophic lateral sclerosis type 9 IDs amyotrophic lateral sclerosis type 9 DOID:0060200 OMIM:611895
				diabetic retinopathy IDs diabetic retinopathy DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

7
Genomic Mutations

1 involving Ang
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Knock-out mice show increased proliferative capacity of hematopoietic stem/progenitor cells and decreased proliferative capacity of myeloid-restricted progenitor cells and develop leukopenia.

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All GO Annotations

80
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

30
cDNA Data

6
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS27034.1

Ensembl

ENSMUSG00000072115 (Evidence)
NCBI Gene

11727

			Length	Strain/Species	Flank
genomic	11727	NCBI Gene Model \| MGI Sequence Detail	10856	C57BL/6J	± kb
transcript	NM_001161731	RefSeq \| MGI Sequence Detail	724	ZRU/MplStud
polypeptide	P21570	UniProt \| EBI \| MGI Sequence Detail	145	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004020 angiogenin

(term hierarchy)
PDB

2BWK, 2BWL
EC

3.1.27.-
InterPro Domains

IPR001427 Pancreatic ribonuclease

IPR023411 Ribonuclease A, active site

IPR023412 Ribonuclease A-domain

IPR036816 Ribonuclease A-like domain superfamily

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All nucleic 9

Genomic 2

cDNA 6

Primer pair 1

Microarray probesets 5

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MGD-MRK-1320, MGI:2145626

Summaries

All 82

Developmental Gene Expression 10

Gene Ontology 13

Phenotypes 15
Earliest

J:10791 Bond MD, et al., Isolation and sequencing of mouse angiogenin DNA. Biochem Biophys Res Commun. 1990 Sep 28;171(3):988-95
Latest

J:357375 Li D, et al., Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization. Cell Metab. 2024 Mar 1;

TSS for Ang:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125397	Chr14:51328546-51328617 (+)	-25 bp
Tssr125398	Chr14:51328628-51328649 (+)	32 bp
Tssr125399	Chr14:51332720-51332725 (+)	4,116 bp
Tssr125400	Chr14:51333845-51333865 (+)	5,248 bp
Tssr125401	Chr14:51333872-51333880 (+)	5,269 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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