Zfp42 MGI Mouse Gene Detail - MGI:99187

Symbol

Zfp42
Name

zinc finger protein 42
Synonyms

Rex-1, Rex1, Zfp-42

Feature Type

protein coding gene
IDs

MGI:99187
NCBI Gene: 22702
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr8:43748100-43760017 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 23.89 cM
Mapping Data

4 experiments

SNPs within 2kb

464 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99187	protein coding gene	Chr8:43748100-43760041 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033566	protein coding gene	Chr8:42219325-42232065 (-)
A/J	MGP_AJ_G0033549	protein coding gene	Chr8:40618437-40630281 (-)
AKR/J	MGP_AKRJ_G0033472	protein coding gene	Chr8:41797211-41811303 (-)
BALB/cJ	MGP_BALBcJ_G0033544	protein coding gene	Chr8:40746299-40758898 (-)
C3H/HeJ	MGP_C3HHeJ_G0033254	protein coding gene	Chr8:42218746-42230581 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034060	protein coding gene	Chr8:43797842-43810045 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031010	protein coding gene	Chr8:37075885-37087312 (-)
CAST/EiJ	MGP_CASTEiJ_G0032582	protein coding gene	Chr8:41708313-41722951 (-)
CBA/J	MGP_CBAJ_G0033232	protein coding gene	Chr8:45619897-45632822 (-)
DBA/2J	MGP_DBA2J_G0033386	protein coding gene	Chr8:40429515-40441845 (-)
FVB/NJ	MGP_FVBNJ_G0033330	protein coding gene	Chr8:39969356-39983316 (-)
LP/J	MGP_LPJ_G0033475	protein coding gene	Chr8:42298281-42310195 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033372	protein coding gene	Chr8:45675616-45688794 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034078	protein coding gene	Chr8:42028306-42039629 (-)
PWK/PhJ	MGP_PWKPhJ_G0032291	protein coding gene	Chr8:39973282-39985837 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032123	protein coding gene	Chr8:41178528-41192675 (-)
WSB/EiJ	MGP_WSBEiJ_G0032697	protein coding gene	Chr8:42201901-42215263 (-)

Human Ortholog

ZFP42, ZFP42 zinc finger protein

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFP42, ZFP42 zinc finger protein
Synonyms

REX-1, REX1, zfp-42, ZNF754
Links

HGNC:30949

NCBI Gene ID: 132625

neXtProt AC: NX_Q96MM3

UniProt: Q96MM3
Chr Location

4q35.2; chr4:187995771-188005246 (+) GRCh38

MGI Vertebrate Homology

Zfp42 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: ZFP42
Gene Tree

Zfp42

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Phenotype Summary

16 phenotypes from 4 alleles in 4 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

92
Endonuclease-mediated

2
Gene trapped

84
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one knock-out allele exhibit premature age-related male germ cell loss, abnormal sperm morphology, and mild testicular atrophy.

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All GO Annotations

27
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

44
cDNA Data

34
Literature Summary

30

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

12
UniProt

2
CCDS

CCDS22267.1

Ensembl

ENSMUSG00000051176 (Evidence)
NCBI Gene

22702

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051176	Ensembl Gene Model \| MGI Sequence Detail	11918	C57BL/6J	± kb
transcript	ENSMUST00000211248	Ensembl \| MGI Sequence Detail	1837	Not Applicable
polypeptide	ENSMUSP00000147606	Ensembl \| MGI Sequence Detail	288	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017644 zinc finger protein 42

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 44

Genomic 3

cDNA 34

Primer pair 7

Microarray probesets 3

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MGD-MRK-13848, MGD-MRK-13849, MGD-MRK-15884, MGD-MRK-15939

Summaries

All 81

Developmental Gene Expression 30

Gene Ontology 11

Phenotypes 18
Earliest

J:10124 Hosler BA, et al., Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells. Mol Cell Biol. 1989 Dec;9(12):5623-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp42:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81140	Chr8:43761449-43761460 (-)	-1,438 bp
Tssr81139	Chr8:43760087-43760095 (-)	-74 bp
Tssr81138	Chr8:43760079-43760084 (-)	-65 bp
Tssr81137	Chr8:43760057-43760072 (-)	-48 bp
Tssr81136	Chr8:43760028-43760046 (-)	-20 bp
Tssr81135	Chr8:43759993-43760002 (-)	19 bp
Tssr81134	Chr8:43759760-43759781 (-)	246 bp
Tssr81133	Chr8:43759727-43759738 (-)	284 bp
Tssr81132	Chr8:43759382-43759388 (-)	632 bp
Tssr81131	Chr8:43758957-43758963 (-)	1,057 bp
Tssr81130	Chr8:43758935-43758947 (-)	1,076 bp
Tssr81129	Chr8:43758907-43758917 (-)	1,105 bp
Tssr81128	Chr8:43758873-43758886 (-)	1,137 bp
Tssr81127	Chr8:43757710-43757713 (-)	2,305 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24