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Fech Gene Detail
Summary
  • Symbol
    Fech
  • Name
    ferrochelatase
  • Synonyms
    fch, Fcl
  • Feature Type
    protein coding gene
  • IDs
    MGI:95513
    NCBI Gene: 14151
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:64589613-64622169 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 37.43 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    979 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95513
 protein coding gene Chr18:64585985-64623322 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024503
 protein coding gene Chr18:64505332-64539833 (-)
A/J MGP_AJ_G0024470
 protein coding gene Chr18:61730871-61762986 (-)
AKR/J MGP_AKRJ_G0024440
 protein coding gene Chr18:63457441-63490243 (-)
BALB/cJ MGP_BALBcJ_G0024469
 protein coding gene Chr18:61875779-61908876 (-)
C3H/HeJ MGP_C3HHeJ_G0024237
 protein coding gene Chr18:63674995-63708859 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024916
 protein coding gene Chr18:66242503-66275218 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022347
 protein coding gene Chr18:61173701-61208144 (-)
CAST/EiJ MGP_CASTEiJ_G0023710
 protein coding gene Chr18:63592685-63625134 (-)
CBA/J MGP_CBAJ_G0024207
 protein coding gene Chr18:68388319-68420669 (-)
DBA/2J MGP_DBA2J_G0024337
 protein coding gene Chr18:61397543-61430126 (-)
FVB/NJ MGP_FVBNJ_G0024303
 protein coding gene Chr18:60774315-60808182 (-)
LP/J MGP_LPJ_G0024421
 protein coding gene Chr18:64373515-64407068 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024332
 protein coding gene Chr18:69885551-69919965 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024963
 protein coding gene Chr18:63671268-63703674 (-)
PWK/PhJ MGP_PWKPhJ_G0023453
 protein coding gene Chr18:61625105-61658269 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023258
 protein coding gene Chr18:63819455-63854795 (-)
WSB/EiJ MGP_WSBEiJ_G0023774
 protein coding gene Chr18:63527213-63561633 (-)



Homology
more
  • Human Ortholog
    FECH, ferrochelatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FECH, ferrochelatase
  • Synonyms
    EPP, EPP1, FCE
  • Links
    NCBI Gene ID: 2235
    neXtProt AC: NX_P22830
    UniProt: P22830

  • Chr Location
    18q21.31; chr18:57544377-57586732 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fech mouse models; 2 with human FECH associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for an ENU-induced mutation exhibit hemolytic anemia, photosensitivity, cholestasis, and hepatic dysfunction. Homozygotes for a targeted null mutation die prior to embryonic day 3.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    99
  • cDNA Data
    151
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14151 NCBI Gene Model | MGI Sequence Detail 32557 C57BL/6J ±  kb
    transcript NM_007998 RefSeq | MGI Sequence Detail 2941 ZRU/MplStud  
    polypeptide P22315 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 153
      cDNA 151
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-9737, MGD-MRK-9755, MGI:2147283
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 7
      Diseases 3
      Gene Ontology 28
      Phenotypes 28
    • Earliest
      J:5439 Bannerman RM, et al., Hereditary disorders of the red cell in animals. Prog Hematol. 1973;8:131-79
    • Latest
      J:302527 Sardar Pasha SPB, et al., Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response. Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):36
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory