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Myd88 Gene Detail
Summary
  • Symbol
    Myd88
  • Name
    myeloid differentiation primary response gene 88
  • Feature Type
    protein coding gene
  • IDs
    MGI:108005
    NCBI Gene: 17874
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:119165000-119169084 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108005
 protein coding gene Chr9:119165000-119170477 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035416
 protein coding gene Chr9:122098083-122103560 (-)
A/J MGP_AJ_G0035397
 protein coding gene Chr9:117555482-117560953 (-)
AKR/J MGP_AKRJ_G0035330
 protein coding gene Chr9:120623615-120629087 (-)
BALB/cJ MGP_BALBcJ_G0035393
 protein coding gene Chr9:117432297-117437768 (-)
C3H/HeJ MGP_C3HHeJ_G0035101
 protein coding gene Chr9:121086398-121091869 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035916
 protein coding gene Chr9:125435131-125440608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032798
 protein coding gene Chr9:114754509-114759966 (-)
CAST/EiJ MGP_CASTEiJ_G0034404
 protein coding gene Chr9:121063881-121069359 (-)
CBA/J MGP_CBAJ_G0035068
 protein coding gene Chr9:130143097-130148569 (-)
DBA/2J MGP_DBA2J_G0035227
 protein coding gene Chr9:116998145-117003617 (-)
FVB/NJ MGP_FVBNJ_G0035174
 protein coding gene Chr9:115849348-115854996 (-)
LP/J MGP_LPJ_G0035306
 protein coding gene Chr9:122445962-122452924 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035215
 protein coding gene Chr9:131115286-131122663 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035935
 protein coding gene Chr9:121001979-121005915 (-)
PWK/PhJ MGP_PWKPhJ_G0034110
 protein coding gene Chr9:117422061-117427532 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033946
 protein coding gene Chr9:121109701-121115169 (-)
WSB/EiJ MGP_WSBEiJ_G0034525
 protein coding gene Chr9:120892056-120897528 (-)



Homology
more
  • Human Ortholog
    MYD88, MYD88 innate immune signal transduction adaptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYD88, MYD88 innate immune signal transduction adaptor
  • Synonyms
    IMD68, MYD88D, WM1
  • Links
    NCBI Gene ID: 4615
    neXtProt AC: NX_Q99836
    UniProt: Q99836

  • Chr Location
    3p22.2; chr3:38138552-38143024 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Myd88 mouse models; 11 with human MYD88 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    119 phenotypes from 14 alleles in 22 genetic backgrounds
    26 phenotypes from multigenic genotypes
    1903 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology. Conditional expression of the p.L252P mutation in B cells leads to increased proliferation and survival of B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    170
  • GO References
    51
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    35
  • cDNA Data
    65
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17874 NCBI Gene Model | MGI Sequence Detail 4085 C57BL/6J ±  kb
    transcript NM_010851 RefSeq | MGI Sequence Detail 1965 Not Specified  
    polypeptide P22366 UniProt | EBI | MGI Sequence Detail 296 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000001740 myeloid differentiation primary response protein MyD88
      (term hierarchy)
    • InterPro Domains
      IPR000488 Death domain
      IPR011029 Death-like domain superfamily
      IPR034249 MyD88, death domain
      IPR017281 Myeloid differentiation primary response protein MyD88
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 73
      Genomic 4
      cDNA 65
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37039
    References
    more
    • Summaries
      All 2219
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 51
      Phenotypes 1903
    • Earliest
      J:36886 Lord KA, et al., Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. Oncogene. 1990 Jul;5(7):1095-7
    • Latest
      J:354803 Lee A, et al., BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance. Nat Immunol. 2024 Jan;25(1):41-53
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory