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Mov10 Gene Detail
Summary
  • Symbol
    Mov10
  • Name
    Mov10 RISC complex RNA helicase
  • Synonyms
    Mov-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:97054
    NCBI Gene: 17454
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:104702152-104725879 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.87 cM, cytoband F2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    572 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97054
 protein coding gene Chr3:104702144-104725935 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027711
 protein coding gene Chr3:106118180-106139348 (-)
A/J MGP_AJ_G0027671
 protein coding gene Chr3:102736772-102758707 (-)
AKR/J MGP_AKRJ_G0027636
 protein coding gene Chr3:105262939-105285878 (-)
BALB/cJ MGP_BALBcJ_G0027683
 protein coding gene Chr3:102521770-102544835 (-)
C3H/HeJ MGP_C3HHeJ_G0027413
 protein coding gene Chr3:105644432-105666928 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028127
 protein coding gene Chr3:110082142-110107979 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025467
 protein coding gene Chr3:98847506-98868092 (-)
CAST/EiJ MGP_CASTEiJ_G0026869
 protein coding gene Chr3:104759624-104783528 (-)
CBA/J MGP_CBAJ_G0027388
 protein coding gene Chr3:113829112-113856597 (-)
DBA/2J MGP_DBA2J_G0027530
 protein coding gene Chr3:101990615-102013305 (-)
FVB/NJ MGP_FVBNJ_G0027498
 protein coding gene Chr3:99913170-99934898 (-)
LP/J MGP_LPJ_G0027637
 protein coding gene Chr3:107499158-107522106 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027528
 protein coding gene Chr3:119952768-119978784 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028182
 protein coding gene Chr3:104823235-104844506 (-)
PWK/PhJ MGP_PWKPhJ_G0026595
 protein coding gene Chr3:101766704-101788306 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026416
 protein coding gene Chr3:102859913-102887583 (-)
WSB/EiJ MGP_WSBEiJ_G0026949
 protein coding gene Chr3:105401521-105424087 (-)



Homology
more
  • Human Ortholog
    MOV10, Mov10 RNA helicase
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MOV10, Mov10 RNA helicase
  • Synonyms
    fSAP113, gb110
  • Links
    NCBI Gene ID: 4343
    neXtProt AC: NX_Q9HCE1
    UniProt: Q9HCE1

  • Chr Location
    1p13.2; chr1:112673141-112700756 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MOV10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is embryonic lethal. Heterozygous knockout leads to reduced dendritic branching of neurons, which affects anxiety- and/or activity-related behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    19
  • cDNA Data
    89
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002227 Ensembl Gene Model | MGI Sequence Detail 23728 C57BL/6J ±  kb
    transcript ENSMUST00000106775 Ensembl | MGI Sequence Detail 3584 Not Applicable  
    polypeptide ENSMUSP00000102387 Ensembl | MGI Sequence Detail 1077 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      Genomic 4
      cDNA 89

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12359, MGD-MRK-12377, MGI:2140051
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:6514 Jaenisch R, et al., Chromosomal position and activation of retroviral genomes inserted into the germ line of mice. Cell. 1981 May;24(2):519-29
    • Latest
      J:335634 Guan Y, et al., The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice. PLoS Genet. 2023 May;19(5):e1010566
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory