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Ggta1 Gene Detail
Summary
  • Symbol
    Ggta1
  • Name
    glycoprotein galactosyltransferase alpha 1, 3
  • Synonyms
    alpha3GalT, alpha Gal, Gal, GALT, Ggta, Ggta-1, glycoprotein alpha galactosyl transferase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95704
    NCBI Gene: 14594
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:35290191-35353243 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 23.60 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1527 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95704
 protein coding gene Chr2:35290191-35354393 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025655
 protein coding gene Chr2:34036556-34110448 (-)
A/J MGP_AJ_G0025632
 protein coding gene Chr2:32597029-32666106 (-)
AKR/J MGP_AKRJ_G0025602
 protein coding gene Chr2:33741073-33809540 (-)
BALB/cJ MGP_BALBcJ_G0025629
 protein coding gene Chr2:32705404-32774395 (-)
C3H/HeJ MGP_C3HHeJ_G0025389
 protein coding gene Chr2:33635261-33705406 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026073
 protein coding gene Chr2:35018053-35096142 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023482
 protein coding gene Chr2:31278449-31347045 (-)
CAST/EiJ MGP_CASTEiJ_G0024851
 protein coding gene Chr2:33633824-33710388 (-)
CBA/J MGP_CBAJ_G0025367
 protein coding gene Chr2:36361346-36440861 (-)
DBA/2J MGP_DBA2J_G0025500
 protein coding gene Chr2:32360448-32430062 (-)
FVB/NJ MGP_FVBNJ_G0025462
 protein coding gene Chr2:32261390-32331457 (-)
LP/J MGP_LPJ_G0025586
 protein coding gene Chr2:33957128-34033922 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025493
 protein coding gene Chr2:35867939-35941024 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026131
 protein coding gene Chr2:33628902-33698218 (-)
PWK/PhJ MGP_PWKPhJ_G0024599
 protein coding gene Chr2:32276020-32346448 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024399
 protein coding gene Chr2:33803621-33882106 (-)
WSB/EiJ MGP_WSBEiJ_G0024920
 protein coding gene Chr2:33809662-33887696 (-)



Homology
more
  • Human Ortholog
    GGTA1, glycoprotein alpha-galactosyltransferase 1 (inactive)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GGTA1, glycoprotein alpha-galactosyltransferase 1 (inactive)
  • Synonyms
    a1/3GTP, GGTA, GGTA1P, GLYT2
  • Links
    NCBI Gene ID: 2681
    UniProt: Q4G0N0

  • Chr Location
    9q33.2; chr9:121444990-121499844 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene display defects in humoral immune responses. Homozygous KO also causes cortical cataracts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    95
  • cDNA Data
    79
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035778 Ensembl Gene Model | MGI Sequence Detail 63053 C57BL/6J ±  kb
    transcript ENSMUST00000102794 Ensembl | MGI Sequence Detail 3606 Not Applicable  
    polypeptide ENSMUSP00000099858 Ensembl | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      Genomic 7
      cDNA 80
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10064, MGD-MRK-10065, MGD-MRK-10066, MGI:2139304
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 46
    • Earliest
      J:14645 Sheares BT, et al., Modulation of two distinct galactosyltransferase activities in populations of mouse peritoneal macrophages. J Immunol. 1987 Dec 1;139(11):3748-52
    • Latest
      J:346968 Naso F, et al., Correlations between the alpha-Gal antigen, antibody response and calcification of cardiac valve bioprostheses: experimental evidence obtained using an alpha-Gal knockout mouse animal model. Front Immunol. 2023;14:1210098
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory