About   Help   FAQ
Cyp2d11 Gene Detail
Summary
  • Symbol
    Cyp2d11
  • Name
    cytochrome P450, family 2, subfamily d, polypeptide 11
  • Synonyms
    Cyp2d, P450-2D
  • Feature Type
    protein coding gene
  • IDs
    MGI:88603
    NCBI Gene: 545123
  • Member of
    Cyp2d cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr15:82273355-82278223 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 38.58 cM
Strain
Comparison
more
  • SNPs within 2kb
    349 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88603
 protein coding gene Chr15:82273355-82278223 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022147
 protein coding gene Chr15:82899765-82904437 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0021884
 protein coding gene Chr15:82206660-82212122 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022557
 protein coding gene Chr15:86165120-86170193 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020085
 protein coding gene Chr15:76391131-76395931 (-)
CAST/EiJ MGP_CASTEiJ_G0021404
 protein coding gene Chr15:82992692-83000953 (-)
CBA/J MGP_CBAJ_G0021849
 protein coding gene Chr15:88859082-88874262 (-)
DBA/2J MGP_DBA2J_G0021977
 protein coding gene Chr15:79430314-79433254 (-)
FVB/NJ MGP_FVBNJ_G0021954
 protein coding gene Chr15:78498124-78503984 (-)
LP/J MGP_LPJ_G0022046
 protein coding gene Chr15:83064969-83085053 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021975
 protein coding gene Chr15:93759858-93766093 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022570
 protein coding gene Chr15:82290971-82294501 (-)
PWK/PhJ MGP_PWKPhJ_G0021149
 protein coding gene Chr15:79675575-79680400 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CYP2D6, cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2D6, cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)
  • Synonyms
    CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450C2D, P450-DB1, P450DB1
  • Links
    NCBI Gene ID: 1565
    neXtProt AC: NX_P10635
    UniProt: P10635

  • Chr Location
    22q13.2; chr22:42126499-42130865 (-)  GRCh38
  • Human Ortholog
    CYP2D7, cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)
  • Synonyms
    CYP2D, CYP2D@, CYP2D6, CYP2D7AP, CYP2D7P, CYP2D7P1, P450C2D, P450DB1, RNA40057
  • Links
    NCBI Gene ID: 1564
    neXtProt AC: NX_A0A087X1C5
    UniProt: A0A087X1C5

  • Chr Location
    22q13.2; chr22:42139576-42149455 (-)  GRCh38
Human Diseases
more
  • Diseases
    9 with human CYP2D6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 545123 NCBI Gene Model | MGI Sequence Detail 4869 C57BL/6J ±  kb
transcript NM_001104531 RefSeq | MGI Sequence Detail 1590 ZRU/MplStud  
polypeptide P24457 UniProt | EBI | MGI Sequence Detail 504 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    Genomic 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-13111, MGD-MRK-2322
References
more
  • Summaries
    All 42
    Diseases 1
    Gene Ontology 7
    Phenotypes 25
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:286122 Henderson CJ, et al., An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials. Drug Metab Dispos. 2019 Jun;47(6):601-615
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory