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Impdh2 Gene Detail
Summary
  • Symbol
    Impdh2
  • Name
    inosine monophosphate dehydrogenase 2
  • Synonyms
    IMP dehydrogenase type II
  • Feature Type
    protein coding gene
  • IDs
    MGI:109367
    NCBI Gene: 23918
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108437635-108442776 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109367
 protein coding gene Chr9:108437485-108442783 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035304
 protein coding gene Chr9:110527647-110532950 (+)
A/J MGP_AJ_G0035283
 protein coding gene Chr9:106476346-106481817 (+)
AKR/J MGP_AKRJ_G0035215
 protein coding gene Chr9:109143608-109150911 (+)
BALB/cJ MGP_BALBcJ_G0035277
 protein coding gene Chr9:106171973-106177281 (+)
C3H/HeJ MGP_C3HHeJ_G0034987
 protein coding gene Chr9:109535512-109552259 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035797
 protein coding gene Chr9:113538102-113547633 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032695
 protein coding gene Chr9:103904687-103909933 (+)
CAST/EiJ MGP_CASTEiJ_G0034298
 protein coding gene Chr9:109505079-109510246 (+)
CBA/J MGP_CBAJ_G0034955
 protein coding gene Chr9:117539820-117553832 (+)
DBA/2J MGP_DBA2J_G0035116
 protein coding gene Chr9:105932255-105940782 (+)
FVB/NJ MGP_FVBNJ_G0035064
 protein coding gene Chr9:104695143-104702449 (+)
LP/J MGP_LPJ_G0035192
 protein coding gene Chr9:110721737-110727500 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035103
 protein coding gene Chr9:119116572-119125934 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035818
 protein coding gene Chr9:109424428-109429706 (+)
PWK/PhJ MGP_PWKPhJ_G0034005
 protein coding gene Chr9:106260964-106266219 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033840
 protein coding gene Chr9:109487171-109492459 (+)
WSB/EiJ MGP_WSBEiJ_G0034419
 protein coding gene Chr9:109306205-109311440 (+)



Homology
more
  • Human Ortholog
    IMPDH2, inosine monophosphate dehydrogenase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IMPDH2, inosine monophosphate dehydrogenase 2
  • Synonyms
    IMPD2, IMPDH-II
  • Links
    NCBI Gene ID: 3615
    neXtProt AC: NX_P12268
    UniProt: P12268

  • Chr Location
    3p21.31; chr3:49024325-49029447 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have abnormalities resulting in embryonic lethality around the time of implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    18
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 23918 NCBI Gene Model | MGI Sequence Detail 5142 C57BL/6J ±  kb
transcript NM_001378921 RefSeq | MGI Sequence Detail 1773 C57BL/6  
polypeptide P24547 UniProt | EBI | MGI Sequence Detail 514 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-38412
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:308551 Astrin KH, et al., Mutants of purine metabolism in cultured mouse and hamster cells. Arch Biochem Biophys. 1976 Oct;176(2):397-410
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory