Akp3 MGI Mouse Gene Detail - MGI:87984 - alkaline phosphatase 3, intestine, not Mn requiring

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Akp3 Gene Detail

Symbol

Akp3
Name

alkaline phosphatase 3, intestine, not Mn requiring
Synonyms

Akp-3, IAP

Feature Type

protein coding gene
IDs

MGI:87984
NCBI Gene: 11648
Alliance

gene page
Transcription Start Sites

31 TSS
Candidate for QTL

2 QTL

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Sequence Map

Chr1:87052695-87055634 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 44.06 cM
Mapping Data

17 experiments

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SNPs within 2kb

163 from dbSNP Build 142
Strain Annotations

18
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_87984	protein coding gene	Chr1:87052676-87056450 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016256	protein coding gene	Chr1:88459503-88462442 (+)
A/J	MGP_AJ_G0016237	protein coding gene	Chr1:85156833-85159772 (+)
AKR/J	MGP_AKRJ_G0016198	protein coding gene	Chr1:87670403-87673342 (+)
BALB/cJ	MGP_BALBcJ_G0016194	protein coding gene	Chr1:85277316-85280255 (+)
C3H/HeJ	MGP_C3HHeJ_G0016022	protein coding gene	Chr1:87932624-87935563 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016650	protein coding gene	Chr1:91807480-91810419 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014372	protein coding gene	Chr1:79611238-79614410 (+)
CAST/EiJ	MGP_CASTEiJ_G0015607	protein coding gene	Chr1:87135749-87140247 (+)
CBA/J	MGP_CBAJ_G0015998	protein coding gene	Chr1:94672952-94675891 (+)
DBA/2J	MGP_DBA2J_G0016101	protein coding gene	Chr1:84461238-84464177 (+)
FVB/NJ	MGP_FVBNJ_G0016100	protein coding gene	Chr1:83524039-83526978 (+)
LP/J	MGP_LPJ_G0016172	protein coding gene	Chr1:89526695-89534073 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016126	protein coding gene	Chr1:97957052-97960026 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016693	protein coding gene	Chr1:87772746-87775685 (+)
PWK/PhJ	MGP_PWKPhJ_G0015394	protein coding gene	Chr1:83758539-83761500 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015174	protein coding gene	Chr1:86699607-86702551 (+)
WSB/EiJ	MGP_WSBEiJ_G0015671	protein coding gene	Chr1:87439497-87442424 (+)

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Human Ortholog

ALPG, alkaline phosphatase, germ cell

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALPG, alkaline phosphatase, germ cell
Synonyms

ALPPL, ALPPL2, GCAP
Links

HGNC:441

NCBI Gene ID: 251

neXtProt AC: NX_P10696

UniProt: P10696
Chr Location

2q37.1; chr2:232406844-232410714 (+) GRCh38

Human Ortholog

ALPI, alkaline phosphatase, intestinal
Synonyms

IAP
Links

HGNC:437

NCBI Gene ID: 248

neXtProt AC: NX_P09923

UniProt: P09923
Chr Location

2q37.1; chr2:232456125-232460753 (+) GRCh38

MGI Vertebrate Homology

Akp3 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALPG, ALPI
Gene Tree

Akp3

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Diseases

1 with human ALPI associations

				Human Disease	Mouse Models
				inflammatory bowel disease IDs inflammatory bowel disease DOID:0050589 EFO:0003767 KEGG:05321 MESH:D015212 NCI:C3138 OMIM:PS266600 UMLS_CUI:C0021390

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Akp3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene show no gross abnormalities in appearance, behavior or fertility. They do display accelerated lipid absorption on a high fat diet leading to elevated plasma triglycerides and increased weight gain.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

835
Tissues

114
cDNA Data

5
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

3
CCDS

CCDS15127.1

Ensembl

ENSMUSG00000036500 (Evidence)
NCBI Gene

11648

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000036500	Ensembl Gene Model \| MGI Sequence Detail	2940	C57BL/6J	± kb
	transcript	ENSMUST00000044878	Ensembl \| MGI Sequence Detail	1680	Not Applicable
	polypeptide	ENSMUSP00000037497	Ensembl \| MGI Sequence Detail	559	Not Applicable

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UniProt

3 Sequences
EC

3.1.3.1
InterPro Domains

IPR001952 Alkaline phosphatase

IPR018299 Alkaline phosphatase, active site

IPR017850 Alkaline-phosphatase-like, core domain superfamily
GlyGen

P24822 3 sites

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All nucleic 12

Genomic 3

cDNA 7

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-1250, MGD-MRK-1255

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Summaries

All 60

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:322077 Liu Y, et al., A role for intestinal alkaline phosphatase in preventing liver fibrosis. Theranostics. 2021;11(1):14-26

TSS for Akp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7781	Chr1:87052668-87052682 (+)	-20 bp
Tssr7782	Chr1:87053118-87053125 (+)	427 bp
Tssr7783	Chr1:87053410-87053418 (+)	719 bp
Tssr7784	Chr1:87053653-87053660 (+)	962 bp
Tssr7785	Chr1:87053689-87053699 (+)	999 bp
Tssr7786	Chr1:87053719-87053726 (+)	1,028 bp
Tssr7787	Chr1:87054045-87054055 (+)	1,355 bp
Tssr145	Chr1:87054066-87054074 (+)	1,375 bp
Tssr7788	Chr1:87054447-87054453 (+)	1,755 bp
Tssr7789	Chr1:87054477-87054487 (+)	1,787 bp
Tssr7790	Chr1:87054531-87054540 (+)	1,841 bp
Tssr7791	Chr1:87054655-87054667 (+)	1,966 bp
Tssr7792	Chr1:87054683-87054693 (+)	1,993 bp
Tssr7793	Chr1:87054696-87054704 (+)	2,005 bp
Tssr7794	Chr1:87054713-87054717 (+)	2,020 bp
Tssr7795	Chr1:87054739-87054749 (+)	2,049 bp
Tssr7796	Chr1:87054762-87054772 (+)	2,072 bp
Tssr7797	Chr1:87054779-87054785 (+)	2,087 bp
Tssr7798	Chr1:87054816-87054823 (+)	2,125 bp
Tssr7799	Chr1:87055052-87055060 (+)	2,361 bp
Tssr7800	Chr1:87055071-87055096 (+)	2,389 bp
Tssr7801	Chr1:87055130-87055141 (+)	2,441 bp
Tssr7802	Chr1:87055257-87055263 (+)	2,565 bp
Tssr146	Chr1:87055310-87055316 (+)	2,618 bp
Tssr7803	Chr1:87055318-87055323 (+)	2,626 bp
Tssr7804	Chr1:87055342-87055348 (+)	2,650 bp
Tssr7805	Chr1:87055416-87055417 (+)	2,722 bp
Tssr7806	Chr1:87055430-87055433 (+)	2,737 bp
Tssr7807	Chr1:87055450-87055462 (+)	2,761 bp
Tssr7808	Chr1:87055555-87055558 (+)	2,862 bp
Tssr7809	Chr1:87055625-87055635 (+)	2,935 bp

Akp3 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Alcw1	Chr1, 80.33 cM	Chr1:170868354-171966357	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 1, several candidate genes were identified for Ap1q at 60 cM andAlcw1 at 95.8 cM. Candidate genes for Ap1q are Akp3 (51.7 cM), Gbx2 (65 cM), and Pam (57.5 cM). Candidate genes for Alcw1 are Adss, 2810484M10Rik, and Mark1.
Ap1q	Chr1, 63.28 cM	Chr1:146908199-167586222	J:98595	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 1, several candidate genes were identified for Ap1q at 60 cM andAlcw1 at 95.8 cM. Candidate genes for Ap1q are Akp3 (51.7 cM), Gbx2 (65 cM), and Pam (57.5 cM). Candidate genes for Alcw1 are Adss, 2810484M10Rik, and Mark1.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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