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Fas Gene Detail
Summary
  • Symbol
    Fas
  • Name
    Fas cell surface death receptor
  • Synonyms
    APO-1, CD95, TNFR6, Tnfrsf6
  • Feature Type
    protein coding gene
  • IDs
    MGI:95484
    NCBI Gene: 14102
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:34268066-34305172 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 29.48 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1157 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95484
 protein coding gene Chr19:34267926-34305175 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025056
 protein coding gene Chr19:33031602-33070458 (+)
A/J MGP_AJ_G0025034
 protein coding gene Chr19:31421340-31459421 (+)
AKR/J MGP_AKRJ_G0025000
 protein coding gene Chr19:32486067-32523040 (+)
BALB/cJ MGP_BALBcJ_G0025030
 protein coding gene Chr19:31536947-31573182 (+)
C3H/HeJ MGP_C3HHeJ_G0024789
 protein coding gene Chr19:32582692-32625318 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025471
 protein coding gene Chr19:33974321-34011963 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022889
 protein coding gene Chr19:30866241-30901335 (+)
CAST/EiJ MGP_CASTEiJ_G0024259
 protein coding gene Chr19:32323626-32364667 (+)
CBA/J MGP_CBAJ_G0024766
 protein coding gene Chr19:35563738-35599060 (+)
DBA/2J MGP_DBA2J_G0024898
 protein coding gene Chr19:31324524-31360750 (+)
FVB/NJ MGP_FVBNJ_G0024859
 protein coding gene Chr19:31166699-31203368 (+)
LP/J MGP_LPJ_G0024984
 protein coding gene Chr19:33114032-33151209 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024890
 protein coding gene Chr19:35364951-35401896 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025529
 protein coding gene Chr19:32584637-32625217 (+)
PWK/PhJ MGP_PWKPhJ_G0024008
 protein coding gene Chr19:31130249-31167948 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023809
 protein coding gene Chr19:31432436-31473844 (+)
WSB/EiJ MGP_WSBEiJ_G0024323
 protein coding gene Chr19:32656602-32693398 (+)



Homology
more
  • Human Ortholog
    FAS, Fas cell surface death receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAS, Fas cell surface death receptor
  • Synonyms
    ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
  • Links
    NCBI Gene ID: 355
    neXtProt AC: NX_P25445
    UniProt: P25445

  • Chr Location
    10q23.31; chr10:88953813-89029605 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Fas mouse models; 20 with human FAS associations

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 5 models
      
IDs
 View 4 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    19 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    190 phenotypes from 11 alleles in 40 genetic backgrounds
    218 phenotypes from multigenic genotypes
    2 images
    1095 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this locus affect immune function and homozygotes show varying severity of lymphadenopathy, splenomegaly, lymphocytic infiltrations, elevated immunoglobulin levels, autoantibodies, impaired clonal deletion of T cells, and lupus-like disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    112
  • GO References
    48
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    73
  • cDNA Data
    28
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024778 Ensembl Gene Model | MGI Sequence Detail 37107 C57BL/6J ±  kb
    transcript ENSMUST00000025691 Ensembl | MGI Sequence Detail 1481 Not Applicable  
    polypeptide ENSMUSP00000025691 Ensembl | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 2
      cDNA 28
      Primer pair 6
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11878, MGD-MRK-9711, MGI:2147489
    References
    more
    • Summaries
      All 1511
      Developmental Gene Expression 42
      Diseases 19
      Gene Ontology 48
      Phenotypes 1095
    • Earliest
      J:27634 Andrews BS, et al., Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med. 1978 Nov 1;148(5):1198-215
    • Latest
      J:355701 Bohat R, et al., Fas(lpr) gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus. Clin Immunol. 2024 Jan;258:109874
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory