About   Help   FAQ
Uox Gene Detail
Summary
  • Symbol
    Uox
  • Name
    urate oxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:98907
    NCBI Gene: 22262
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:146302904-146337238 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 72.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1111 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98907
 protein coding gene Chr3:146276181-146338060 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027975
 protein coding gene Chr3:150096973-150160145 (+)
A/J MGP_AJ_G0027934
 protein coding gene Chr3:144701155-144763685 (+)
AKR/J MGP_AKRJ_G0027900
 protein coding gene Chr3:148564845-148634348 (+)
BALB/cJ MGP_BALBcJ_G0027946
 protein coding gene Chr3:144525853-144587451 (+)
C3H/HeJ MGP_C3HHeJ_G0027676
 protein coding gene Chr3:148932704-148998929 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028389
 protein coding gene Chr3:155120608-155188591 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025727
 protein coding gene Chr3:139760842-139821919 (+)
CAST/EiJ MGP_CASTEiJ_G0027129
 protein coding gene Chr3:148914927-148984726 (+)
CBA/J MGP_CBAJ_G0027651
 protein coding gene Chr3:160627277-160697827 (+)
DBA/2J MGP_DBA2J_G0027791
 protein coding gene Chr3:143853034-143917218 (+)
FVB/NJ MGP_FVBNJ_G0027758
 protein coding gene Chr3:141270143-141331153 (+)
LP/J MGP_LPJ_G0027902
 protein coding gene Chr3:151479550-151544098 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027791
 protein coding gene Chr3:168907813-168974787 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028448
 protein coding gene Chr3:148150028-148214276 (+)
PWK/PhJ MGP_PWKPhJ_G0026852
 protein coding gene Chr3:143710054-143775372 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026680
 protein coding gene Chr3:146311847-146379086 (+)
WSB/EiJ MGP_WSBEiJ_G0027209
 protein coding gene Chr3:149130633-149196687 (+)



Homology
more
  • Human Ortholog
    UOX, urate oxidase (pseudogene)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UOX, urate oxidase (pseudogene)
  • Synonyms
    UOXP, URICASE
  • Links
    NCBI Gene ID: 391051

  • Chr Location
    1p31.1
Human Diseases
more
  • Diseases
    2 with Uox mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit marked hyperuricemia and urate nephropathy. Most mutants die prior to four weeks of age. Homozygotes for a large paracentric inversion disrupting this same gene exhibit a similar phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    908
  • Tissues
    97
  • cDNA Data
    118
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22262 NCBI Gene Model | MGI Sequence Detail 34335 C57BL/6J ±  kb
    transcript NM_009474 RefSeq | MGI Sequence Detail 1843 ZRU/MplStud  
    polypeptide P25688 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      Genomic 2
      cDNA 118
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15358, MGI:2139782
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Diseases 4
      Gene Ontology 8
      Phenotypes 29
    • Earliest
      J:297524 Lee PC, Developmental changes of adenosine deaminase, xanthine oxidase, and uricase in mouse tissues. Dev Biol. 1973 Apr;31(2):227-33
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory