S100a8 MGI Mouse Gene Detail - MGI:88244 - S100 calcium binding protein A8 (calgranulin A)

Symbol

S100a8
Name

S100 calcium binding protein A8 (calgranulin A)
Synonyms

60B8Ag, B8Ag, Caga, CFAg, CP-10, MRP8, p8

Feature Type

protein coding gene
IDs

MGI:88244
NCBI Gene: 20201
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:90576378-90577341 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.90 cM, cytoband F1-F2
Mapping Data

5 experiments

SNPs within 2kb

195 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88244	protein coding gene	Chr3:90576285-90577342 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027479	protein coding gene	Chr3:91009239-91010306 (+)
A/J	MGP_AJ_G0027443	protein coding gene	Chr3:87966336-87967393 (+)
AKR/J	MGP_AKRJ_G0027408	protein coding gene	Chr3:90131395-90132452 (+)
BALB/cJ	MGP_BALBcJ_G0027452	protein coding gene	Chr3:87924097-87925156 (+)
C3H/HeJ	MGP_C3HHeJ_G0027194	protein coding gene	Chr3:90294823-90295880 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027898	protein coding gene	Chr3:94412528-94413585 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025251	protein coding gene	Chr3:83468197-83470591 (+)
CAST/EiJ	MGP_CASTEiJ_G0026640	protein coding gene	Chr3:90696532-90697607 (+)
CBA/J	MGP_CBAJ_G0027169	protein coding gene	Chr3:97613750-97614807 (+)
DBA/2J	MGP_DBA2J_G0027306	protein coding gene	Chr3:87333670-87334729 (+)
FVB/NJ	MGP_FVBNJ_G0027274	protein coding gene	Chr3:85661211-85662268 (+)
LP/J	MGP_LPJ_G0027415	protein coding gene	Chr3:92064285-92065352 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027295	protein coding gene	Chr3:103869039-103870103 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027957	protein coding gene	Chr3:89882871-89883930 (+)
PWK/PhJ	MGP_PWKPhJ_G0026374	protein coding gene	Chr3:87232561-87233628 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026194	protein coding gene	Chr3:89075687-89076747 (+)
WSB/EiJ	MGP_WSBEiJ_G0026722	protein coding gene	Chr3:90288819-90289886 (+)

Human Ortholog

S100A8, S100 calcium binding protein A8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

S100A8, S100 calcium binding protein A8
Synonyms

60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100-A8
Links

HGNC:10498

NCBI Gene ID: 6279

neXtProt AC: NX_P05109

UniProt: P05109
Chr Location

1q21.3; chr1:153390032-153422583 (-) GRCh38

MGI Vertebrate Homology

S100a8 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: S100A8
Gene Tree

S100a8

Diseases

1 with human S100A8 associations

				Human Disease	Mouse Models
				myocarditis IDs myocarditis DOID:820 ICD10CM:I51.4 ICD9CM:429.0 KEGG:05416 MESH:D009205 NCI:C34831 UMLS_CUI:C0027059

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
59 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Targeted

7
Genomic Mutations

3 involving S100a8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available

Homozygous disruption of this gene results in complete embryonic lethality. The exact timing of lethality varies between alleles.

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All GO Annotations

45
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

18
cDNA Data

20
Literature Summary

17

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS38507.1

Ensembl

ENSMUSG00000056054 (Evidence)
NCBI Gene

20201

			Length	Strain/Species	Flank
genomic	20201	NCBI Gene Model \| MGI Sequence Detail	964	C57BL/6J	± kb
transcript	NM_013650	RefSeq \| MGI Sequence Detail	392	ZRU/MplStud
polypeptide	P27005	UniProt \| EBI \| MGI Sequence Detail	89	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014417 protein S100-A8

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR013787 S100/CaBP-9k-type, calcium binding, subdomain

IPR001751 S100/Calcium binding protein 7/8-like, conserved site

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All nucleic 27

Genomic 3

cDNA 20

Primer pair 2

Other 2

Microarray probesets 3

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MGD-MRK-1725, MGI:2139672

Summaries

All 167

Developmental Gene Expression 17

Diseases 1

Gene Ontology 13

Phenotypes 59
Earliest

J:1255 Lagasse E, et al., Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood. 1992 Apr 15;79(8):1907-15
Latest

J:355461 Deng Z, et al., Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure. Heliyon. 2024 Sep 15;10(17):e37259

TSS for S100a8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30265	Chr3:90576370-90576383 (+)	-1 bp
Tssr30266	Chr3:90576840-90576881 (+)	483 bp
Tssr30267	Chr3:90577236-90577247 (+)	864 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24