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Tgfb2 Gene Detail
Summary
  • Symbol
    Tgfb2
  • Name
    transforming growth factor, beta 2
  • Synonyms
    Tgfb-2, Tgf-beta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98726
    NCBI Gene: 21808
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:186354989-186438186 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 89.95 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1984 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98726
 protein coding gene Chr1:186354984-186441504 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016919
 protein coding gene Chr1:193412502-193500868 (-)
A/J MGP_AJ_G0016898
 protein coding gene Chr1:185504633-185588687 (-)
AKR/J MGP_AKRJ_G0016863
 protein coding gene Chr1:190959586-191046413 (-)
BALB/cJ MGP_BALBcJ_G0016856
 protein coding gene Chr1:186172886-186260740 (-)
C3H/HeJ MGP_C3HHeJ_G0016680
 protein coding gene Chr1:191830997-191921378 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017319
 protein coding gene Chr1:199581277-199672392 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015026
 protein coding gene Chr1:176480747-176564052 (-)
CAST/EiJ MGP_CASTEiJ_G0016263
 protein coding gene Chr1:191296824-191397548 (-)
CBA/J MGP_CBAJ_G0016654
 protein coding gene Chr1:207027088-207128372 (-)
DBA/2J MGP_DBA2J_G0016760
 protein coding gene Chr1:184264955-184351480 (-)
FVB/NJ MGP_FVBNJ_G0016756
 protein coding gene Chr1:182352467-182438202 (-)
LP/J MGP_LPJ_G0016835
 protein coding gene Chr1:194582424-194674478 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016788
 protein coding gene Chr1:213864733-213952182 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017356
 protein coding gene Chr1:190853339-190947132 (-)
PWK/PhJ MGP_PWKPhJ_G0016050
 protein coding gene Chr1:183479772-183564543 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015826
 protein coding gene Chr1:189801519-189897490 (-)
WSB/EiJ MGP_WSBEiJ_G0016325
 protein coding gene Chr1:191028876-191118093 (-)



Homology
more
  • Human Ortholog
    TGFB2, transforming growth factor beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGFB2, transforming growth factor beta 2
  • Synonyms
    G-TSF, LDS4, TGF-beta2
  • Links
    NCBI Gene ID: 7042
    neXtProt AC: NX_P61812
    UniProt: P61812

  • Chr Location
    1q41; chr1:218345336-218444619 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tgfb2 mouse models; 3 with human TGFB2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    124 phenotypes from 1 allele in 5 genetic backgrounds
    28 phenotypes from multigenic genotypes
    2 images
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defects of the heart, lungs, skull, limbs, spinal column, eyes, inner ears, and urogenital system, and perinatal mortality. Heterozygotes show abnormalities of the Cowpers' gland and intestinal mucosa.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    209
  • GO References
    32
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1616
  • Tissues
    545
  • cDNA Data
    100
  • Literature Summary
    234
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039239 Ensembl Gene Model | MGI Sequence Detail 83198 C57BL/6J ±  kb
    transcript ENSMUST00000195201 Ensembl | MGI Sequence Detail 3485 Not Applicable  
    polypeptide ENSMUSP00000142149 Ensembl | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 151
      Genomic 1
      cDNA 106
      Primer pair 28
      Other 16

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15065, MGD-MRK-15068, MGI:2138633
    References
    more
    • Summaries
      All 401
      Developmental Gene Expression 234
      Diseases 1
      Gene Ontology 32
      Phenotypes 59
    • Earliest
      J:9636 Barton DE, et al., Chromosomal mapping of genes for transforming growth factors beta 2 and beta 3 in man and mouse: dispersion of TGF-beta gene family. Oncogene Res. 1988;3(4):323-31
    • Latest
      J:353622 Dinesh NEH, et al., Fibronectin Isoforms Promote Postnatal Skeletal Development. Matrix Biol. 2024 Aug 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory