Lef1 Gene Detail

Summary

• Symbol
  Lef1
• Name
  lymphoid enhancer binding factor 1
• Synonyms
  Lef-1, lymphoid enhancer factor 1

• Feature Type
  protein coding gene
• IDs
  MGI:96770
  NCBI Gene: 16842
• Alliance
  gene page
• Transcription Start Sites
  43 TSS

Location &
Maps

• Sequence Map
  Chr3:130904120-131018005 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 60.78 cM
• Mapping Data
  8 experiments

Strain
Comparison

• SNPs within 2kb
  3509 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96770	protein coding gene	Chr3:130903972-131018006 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027885	protein coding gene	Chr3:133893980-134018711 (+)
A/J	MGP_AJ_G0027843	protein coding gene	Chr3:129177308-129293757 (+)
AKR/J	MGP_AKRJ_G0027808	protein coding gene	Chr3:132540303-132663031 (+)
BALB/cJ	MGP_BALBcJ_G0027856	protein coding gene	Chr3:129033686-129148335 (+)
C3H/HeJ	MGP_C3HHeJ_G0027585	protein coding gene	Chr3:132950527-133068384 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028299	protein coding gene	Chr3:138610345-138738392 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025637	protein coding gene	Chr3:124699862-124813265 (+)
CAST/EiJ	MGP_CASTEiJ_G0027041	protein coding gene	Chr3:132669635-132789193 (+)
CBA/J	MGP_CBAJ_G0027561	protein coding gene	Chr3:143276913-143405955 (+)
DBA/2J	MGP_DBA2J_G0027701	protein coding gene	Chr3:128382113-128497268 (+)
FVB/NJ	MGP_FVBNJ_G0027668	protein coding gene	Chr3:125962051-126077310 (+)
LP/J	MGP_LPJ_G0027811	protein coding gene	Chr3:135371507-135493527 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027699	protein coding gene	Chr3:151211238-151333291 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028357	protein coding gene	Chr3:132223031-132347121 (+)
PWK/PhJ	MGP_PWKPhJ_G0026765	protein coding gene	Chr3:128123538-128240860 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026590	protein coding gene	Chr3:130269708-130387000 (+)
WSB/EiJ	MGP_WSBEiJ_G0027120	protein coding gene	Chr3:132949670-133075301 (+)

Homology

• Human Ortholog
  LEF1, lymphoid enhancer binding factor 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LEF1, lymphoid enhancer binding factor 1
  
• Synonyms
  LEF-1, TCF10, TCF1ALPHA, TCF7L3
• Links
  HGNC:6551

  NCBI Gene ID: 51176

  neXtProt AC: NX_Q9UJU2

  UniProt: Q9UJU2

  
  
• Chr Location
  4q25; chr4:108047545-108168956 (-)  GRCh38

---

• MGI Vertebrate Homology
  Lef1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: LEF1
• Gene Tree
  Lef1
  

Human Diseases

• Diseases
  1 with human LEF1 associations

				Human Disease	Mouse Models
				ovarian cancer IDs ovarian cancer       DOID:2394 DOID:0060070 DOID:2144 DOID:9595 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213500 ORDO:213517 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247

Click on a disease name to see all genes associated with that disease.

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  52 phenotypes from 5 alleles in 7 genetic backgrounds
  14 phenotypes from multigenic genotypes
  95 phenotype references
  

• All Mutations and Alleles
  21
• Chemically induced (other)
  1
• Endonuclease-mediated
  4
• Gene trapped
  4
• Radiation induced
  1
• Targeted
  9
• Transgenic
  2
• Genomic Mutations
  2 involving Lef1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  43 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a null allele are small and die postnatally showing lack of teeth, mammary and uterine glands, whiskers, body hair, dermal-associated fat, and a dentate gyrus, as well as defects in hippocampus morphology, hair follicle development, retinal vasculature, and vascular regression.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  167
• GO References
  57

Expression

• Assay Results
  2203
• Tissues
  832
• cDNA Data
  75
• Literature Summary
  504

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA LEF1
  Xenbase lef1
  ZFIN lef1

Sequences &
Gene Models

• All Sequences
  75
• RefSeq
  22
• UniProt
  6
• CCDS
  CCDS17842.1, CCDS71319.1, CCDS71320.1

• Ensembl
  ENSMUSG00000027985 (Evidence)
• NCBI Gene
  16842

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000027985	Ensembl Gene Model | MGI Sequence Detail	113886	C57BL/6J
transcript	ENSMUST00000029611	Ensembl | MGI Sequence Detail	3482	Not Applicable
polypeptide	ENSMUSP00000029611	Ensembl | MGI Sequence Detail	397	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000009751 lymphoid enhancer-binding factor 1
  (term hierarchy)
• PDB
  2LEF, 3OUW, 3OUX
• InterPro Domains
  IPR027397 Catenin binding domain superfamily
  IPR013558 CTNNB1 binding, N-teminal
  IPR009071 High mobility group box domain
  IPR036910 High mobility group box domain superfamily
  IPR024940 Transcription factor TCF/LEF

Molecular
Reagents

• All nucleic 135

  Genomic 1

  cDNA 82

  Primer pair 26

  Other 26

  
  

  Microarray probesets 5

Other
Accession IDs

MGD-MRK-11782, MGD-MRK-11783, MGI:2139722

References

• Summaries
  All 684

  Developmental Gene Expression 504

  Diseases 1

  Gene Ontology 57

  Phenotypes 95
• Earliest
  J:10393 Mattei MG, et al., Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man. Oncogene. 1990 Jan;5(1):151-6
• Latest
  J:357896 Sheridan D, et al., Gonadotrophs have a dual origin, with most derived from pituitary stem cells during minipuberty. bioRxiv. 2024;

TSS for Lef1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31683	Chr3:130903931-130903983 (+)	-163 bp
Tssr31684	Chr3:130903985-130903994 (+)	-130 bp
Tssr31685	Chr3:130903999-130904006 (+)	-117 bp
Tssr31686	Chr3:130904054-130904061 (+)	-62 bp
Tssr31687	Chr3:130904288-130904313 (+)	181 bp
Tssr31688	Chr3:130904317-130904335 (+)	206 bp
Tssr31689	Chr3:130904455-130904464 (+)	340 bp
Tssr31690	Chr3:130904467-130904483 (+)	355 bp
Tssr31691	Chr3:130904487-130904498 (+)	373 bp
Tssr31692	Chr3:130904564-130904579 (+)	452 bp
Tssr31693	Chr3:130904844-130904865 (+)	735 bp
Tssr31694	Chr3:130904920-130904938 (+)	809 bp
Tssr31695	Chr3:130905016-130905054 (+)	915 bp
Tssr31696	Chr3:130905166-130905180 (+)	1,053 bp
Tssr31697	Chr3:130905204-130905218 (+)	1,091 bp
Tssr31698	Chr3:130905875-130905898 (+)	1,767 bp
Tssr31699	Chr3:130906113-130906132 (+)	2,003 bp
Tssr31700	Chr3:130906164-130906185 (+)	2,055 bp
Tssr31701	Chr3:130906186-130906198 (+)	2,072 bp
Tssr31702	Chr3:130906203-130906228 (+)	2,096 bp
Tssr31703	Chr3:130906434-130906452 (+)	2,323 bp
Tssr31704	Chr3:130907500-130907514 (+)	3,387 bp
Tssr31705	Chr3:130907530-130907541 (+)	3,416 bp
Tssr31706	Chr3:130917390-130917425 (+)	13,288 bp
Tssr1051	Chr3:130921215-130921227 (+)	17,101 bp
Tssr31707	Chr3:130926912-130926916 (+)	22,794 bp
Tssr31708	Chr3:130928102-130928108 (+)	23,985 bp
Tssr31710	Chr3:130949935-130949949 (+)	45,822 bp
Tssr31711	Chr3:130949956-130949993 (+)	45,855 bp
Tssr31712	Chr3:130950004-130950015 (+)	45,890 bp
Tssr31713	Chr3:130950098-130950106 (+)	45,982 bp
Tssr31714	Chr3:130950107-130950119 (+)	45,993 bp
Tssr31715	Chr3:130953364-130953379 (+)	49,252 bp
Tssr31716	Chr3:130964069-130964085 (+)	59,957 bp
Tssr31717	Chr3:130965351-130965375 (+)	61,243 bp
Tssr31718	Chr3:130978303-130978350 (+)	74,207 bp
Tssr31719	Chr3:130982920-130982925 (+)	78,803 bp
Tssr31720	Chr3:130983440-130983444 (+)	79,322 bp
Tssr31721	Chr3:130993755-130993794 (+)	89,655 bp
Tssr31722	Chr3:131000169-131000173 (+)	96,051 bp
Tssr31723	Chr3:131016440-131016442 (+)	112,321 bp
Tssr31724	Chr3:131017477-131017486 (+)	113,362 bp
Tssr31725	Chr3:131017587-131017600 (+)	113,474 bp