Vav1 MGI Mouse Gene Detail - MGI:98923

Symbol

Vav1
Name

vav 1 oncogene

Feature Type

protein coding gene
IDs

MGI:98923
NCBI Gene: 22324
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr17:57586100-57635031 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.76 cM
Mapping Data

16 experiments

SNPs within 2kb

1587 from dbSNP Build 142
Strain Annotations

18
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98923	protein coding gene	Chr17:57586080-57636236 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023962	protein coding gene	Chr17:59059032-59116375 (+)
A/J	MGP_AJ_G0023920	protein coding gene	Chr17:57411726-57460482 (+)
AKR/J	MGP_AKRJ_G0023889	protein coding gene	Chr17:58138545-58189680 (+)
BALB/cJ	MGP_BALBcJ_G0023921	protein coding gene	Chr17:57248418-57298997 (+)
C3H/HeJ	MGP_C3HHeJ_G0023685	protein coding gene	Chr17:58854980-58906913 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024367	protein coding gene	Chr17:61352794-61406541 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021813	protein coding gene	Chr17:53876708-53926647 (+)
CAST/EiJ	MGP_CASTEiJ_G0023167	protein coding gene	Chr17:59166364-59224601 (+)
CBA/J	MGP_CBAJ_G0023661	protein coding gene	Chr17:63753275-63807838 (+)
DBA/2J	MGP_DBA2J_G0023789	protein coding gene	Chr17:56101176-56150299 (+)
FVB/NJ	MGP_FVBNJ_G0023755	protein coding gene	Chr17:55680926-55730588 (+)
LP/J	MGP_LPJ_G0023871	protein coding gene	Chr17:59735810-59790045 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023783	protein coding gene	Chr17:63169517-63221426 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024411	protein coding gene	Chr17:58501085-58551093 (+)
PWK/PhJ	MGP_PWKPhJ_G0022913	protein coding gene	Chr17:55473249-55524452 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022724	protein coding gene	Chr17:55275697-55332657 (+)
WSB/EiJ	MGP_WSBEiJ_G0023233	protein coding gene	Chr17:59140174-59194240 (+)

Human Ortholog

VAV1, vav guanine nucleotide exchange factor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VAV1, vav guanine nucleotide exchange factor 1
Synonyms

VAV
Links

HGNC:12657

NCBI Gene ID: 7409

neXtProt AC: NX_P15498

UniProt: P15498
Chr Location

19p13.3; chr19:6772708-6857366 (+) GRCh38

MGI Vertebrate Homology

Vav1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: VAV1
Gene Tree

Vav1

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Phenotype Summary

62 phenotypes from 12 alleles in 18 genetic backgrounds
50 phenotypes from multigenic genotypes
121 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (ENU)

6
Endonuclease-mediated

4
Targeted

11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mutants exhibit defective T cell maturation, interleukin-2 production, and cell cycle progression. Immunoglobulin class switching is also impaired and attributed to defective T cell help.

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All GO Annotations

46
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

36
cDNA Data

46
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vav1

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All Sequences

75
RefSeq

7
UniProt

14
CCDS

CCDS28931.1, CCDS50158.1, CCDS50159.1

Ensembl

ENSMUSG00000034116 (Evidence)
NCBI Gene

22324

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034116	Ensembl Gene Model \| MGI Sequence Detail	48932	C57BL/6J	± kb
transcript	ENSMUST00000005889	Ensembl \| MGI Sequence Detail	2963	Not Applicable
polypeptide	ENSMUSP00000005889	Ensembl \| MGI Sequence Detail	845	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000003118 proto-oncogene vav

(term hierarchy)
PDB

1F5X, 1GCP, 1GCQ, 1K1Z, 2KBT, 2VRW
InterPro Domains

IPR022613 Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR003096 Smooth muscle protein/calponin

IPR035730 VAV1 protein, first SH3 domain

IPR035729 VAV1 protein, second SH3 domain

IPR035879 VAV1, SH2 domain

IPR037832 Vav, PH domain

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All nucleic 49

cDNA 46

Primer pair 1

Other 2

Microarray probesets 5

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MGD-MRK-15381

Summaries

All 212

Developmental Gene Expression 6

Gene Ontology 18

Phenotypes 121
Earliest

J:18384 Katzav S, et al., vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 1989 Aug;8(8):2283-90
Latest

J:346951 Machin PA, et al., Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis. Front Immunol. 2023;14:1180886

TSS for Vav1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145394	Chr17:57586094-57586123 (+)	9 bp
Tssr145395	Chr17:57586170-57586181 (+)	76 bp
Tssr145396	Chr17:57588716-57588732 (+)	2,624 bp
Tssr145397	Chr17:57588901-57588912 (+)	2,807 bp
Tssr145398	Chr17:57592358-57592368 (+)	6,263 bp
Tssr145399	Chr17:57610872-57610883 (+)	24,778 bp
Tssr145400	Chr17:57610917-57610951 (+)	24,834 bp
Tssr145401	Chr17:57610966-57610977 (+)	24,872 bp
Tssr145402	Chr17:57618856-57618870 (+)	32,763 bp
Tssr145403	Chr17:57623394-57623422 (+)	37,308 bp
Tssr145404	Chr17:57623619-57623632 (+)	37,526 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24