Dusp1 MGI Mouse Gene Detail - MGI:105120 - dual specificity phosphatase 1

Symbol

Dusp1
Name

dual specificity phosphatase 1
Synonyms

3CH134, erp, mkp-1, MKP1, Ptpn16

Feature Type

protein coding gene
IDs

MGI:105120
NCBI Gene: 19252
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr17:26724565-26727446 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.28 cM, cytoband A2-C
Mapping Data

2 experiments

SNPs within 2kb

113 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105120	protein coding gene	Chr17:26724564-26781102 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023401	protein coding gene	Chr17:25685684-25688613 (-)
A/J	MGP_AJ_G0023360	protein coding gene	Chr17:24895819-24898749 (-)
AKR/J	MGP_AKRJ_G0023326	protein coding gene	Chr17:25025498-25028427 (-)
BALB/cJ	MGP_BALBcJ_G0023365	protein coding gene	Chr17:25130989-25133918 (-)
C3H/HeJ	MGP_C3HHeJ_G0023125	protein coding gene	Chr17:25417141-25420070 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023805	protein coding gene	Chr17:26736332-26739261 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021281	protein coding gene	Chr17:22354293-22357218 (-)
CAST/EiJ	MGP_CASTEiJ_G0022627	protein coding gene	Chr17:25347181-25350107 (-)
CBA/J	MGP_CBAJ_G0023100	protein coding gene	Chr17:27710576-27713505 (-)
DBA/2J	MGP_DBA2J_G0023230	protein coding gene	Chr17:24487515-24490445 (-)
FVB/NJ	MGP_FVBNJ_G0023200	protein coding gene	Chr17:24264610-24267539 (-)
LP/J	MGP_LPJ_G0023307	protein coding gene	Chr17:25945790-25948719 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023219	protein coding gene	Chr17:27242748-27245678 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023847	protein coding gene	Chr17:25372045-25374975 (-)
PWK/PhJ	MGP_PWKPhJ_G0022376	protein coding gene	Chr17:23279870-23282793 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022194	protein coding gene	Chr17:23431017-23433943 (-)
WSB/EiJ	MGP_WSBEiJ_G0022690	protein coding gene	Chr17:25424706-25427635 (-)

Human Ortholog

DUSP1, dual specificity phosphatase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP1, dual specificity phosphatase 1
Synonyms

CL100, HVH1, MKP-1, MKP1, PTPN10
Links

HGNC:3064

NCBI Gene ID: 1843

neXtProt AC: NX_P28562

UniProt: P28562
Chr Location

5q35.1; chr5:172768096-172771195 (-) GRCh38

MGI Vertebrate Homology

Dusp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUSP1
Protein SuperFamily

MAPK_Ptase
Gene Tree

Dusp1

Diseases

1 with human DUSP1 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

65 phenotypes from 3 alleles in 7 genetic backgrounds
9 phenotypes from multigenic genotypes
82 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Gene trapped

1
Radiation induced

2
Targeted

4
Genomic Mutations

2 involving Dusp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice were viable, fertile, and showed no apparent morphological defects.

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All GO Annotations

61
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

935
Tissues

147
cDNA Data

87
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dusp1

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All Sequences

54
RefSeq

2
UniProt

5
CCDS

CCDS28552.1

Ensembl

ENSMUSG00000024190 (Evidence)
NCBI Gene

19252

			Length	Strain/Species	Flank
genomic	19252	NCBI Gene Model \| MGI Sequence Detail	2882	C57BL/6J	± kb
transcript	NM_013642	RefSeq \| MGI Sequence Detail	1952	ZRU/MplStud
polypeptide	P28563	UniProt \| EBI \| MGI Sequence Detail	367	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006736 dual specificity protein phosphatase 1

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR020420 Atypical dual specificity phosphatase, subfamily B

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR008343 Mitogen-activated protein (MAP) kinase phosphatase

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 93

Genomic 1

cDNA 87

Primer pair 4

Other 1

Microarray probesets 3

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MGD-MRK-32161, MGI:2147160

Summaries

All 169

Developmental Gene Expression 18

Gene Ontology 9

Phenotypes 82
Earliest

J:2300 Charles CH, et al., cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene. 1992 Jan;7(1):187-90
Latest

J:353480 Huang S, et al., Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Nat Commun. 2024 Aug 15;15(1):7019

TSS for Dusp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146957	Chr17:26728533-26728543 (-)	-1,092 bp
Tssr5047	Chr17:26728499-26728506 (-)	-1,057 bp
Tssr5046	Chr17:26728490-26728495 (-)	-1,047 bp
Tssr146956	Chr17:26728468-26728473 (-)	-1,025 bp
Tssr5045	Chr17:26728437-26728442 (-)	-994 bp
Tssr146955	Chr17:26727838-26727856 (-)	-401 bp
Tssr146954	Chr17:26727437-26727456 (-)	-1 bp
Tssr146953	Chr17:26727188-26727221 (-)	241 bp
Tssr146952	Chr17:26727163-26727181 (-)	274 bp
Tssr146951	Chr17:26726602-26726633 (-)	828 bp
Tssr146950	Chr17:26726127-26726146 (-)	1,309 bp
Tssr146949	Chr17:26725584-26725605 (-)	1,851 bp
Tssr146948	Chr17:26725517-26725537 (-)	1,919 bp
Tssr146947	Chr17:26725500-26725511 (-)	1,940 bp
Tssr146946	Chr17:26725476-26725490 (-)	1,963 bp
Tssr146945	Chr17:26725412-26725432 (-)	2,024 bp
Tssr146944	Chr17:26725352-26725369 (-)	2,085 bp
Tssr146943	Chr17:26725222-26725244 (-)	2,213 bp
Tssr146942	Chr17:26725146-26725162 (-)	2,292 bp
Tssr146941	Chr17:26725118-26725140 (-)	2,317 bp
Tssr146940	Chr17:26724960-26724971 (-)	2,480 bp
Tssr146939	Chr17:26724929-26724941 (-)	2,511 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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