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Cyp19a1 Gene Detail
Summary
  • Symbol
    Cyp19a1
  • Name
    cytochrome P450, family 19, subfamily a, polypeptide 1
  • Synonyms
    Ar, ArKO, aromatase, Cyp19, Int-5, Int5, p450arom
  • Feature Type
    protein coding gene
  • IDs
    MGI:88587
    NCBI Gene: 13075
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:54073221-54175394 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 29.49 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2286 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88587
 protein coding gene Chr9:54073221-54175448 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034821
 protein coding gene Chr9:53201811-53232631 (-)
A/J MGP_AJ_G0034802
 protein coding gene Chr9:51509769-51537314 (-)
AKR/J MGP_AKRJ_G0034730
 protein coding gene Chr9:52662211-52690443 (-)
BALB/cJ MGP_BALBcJ_G0034794
 protein coding gene Chr9:51273742-51301208 (-)
C3H/HeJ MGP_C3HHeJ_G0034504
 protein coding gene Chr9:53139135-53167406 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035313
 protein coding gene Chr9:54703568-54730472 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032225
 protein coding gene Chr9:50919952-50948008 (-)
CAST/EiJ MGP_CASTEiJ_G0033826
 protein coding gene Chr9:53149349-53178781 (-)
CBA/J MGP_CBAJ_G0034475
 protein coding gene Chr9:56575368-56602494 (-)
DBA/2J MGP_DBA2J_G0034634
 protein coding gene Chr9:51395386-51422744 (-)
FVB/NJ MGP_FVBNJ_G0034576
 protein coding gene Chr9:50591123-50619271 (-)
LP/J MGP_LPJ_G0034716
 protein coding gene Chr9:53510227-53537314 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034619
 protein coding gene Chr9:58149793-58178348 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035335
 protein coding gene Chr9:52667010-52695262 (-)
PWK/PhJ MGP_PWKPhJ_G0033530
 protein coding gene Chr9:51368229-51395916 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033365
 protein coding gene Chr9:52937297-52966446 (-)
WSB/EiJ MGP_WSBEiJ_G0033938
 protein coding gene Chr9:52646209-52674785 (-)



Homology
more
  • Human Ortholog
    CYP19A1, cytochrome P450 family 19 subfamily A member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP19A1, cytochrome P450 family 19 subfamily A member 1
  • Synonyms
    ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM
  • Links
    NCBI Gene ID: 1588
    neXtProt AC: NX_P11511
    UniProt: P11511

  • Chr Location
    15q21.2; chr15:51208057-51338601 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Cyp19a1 mouse models; 12 with human CYP19A1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    171 phenotypes from 7 alleles in 10 genetic backgrounds
    22 phenotypes from multigenic genotypes
    3 images
    144 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for various mutations that inactivate the gene exhibit defects affecting fertility including impairments of ovulation, spermiogenesis and mounting behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    986
  • Tissues
    188
  • cDNA Data
    14
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032274 Ensembl Gene Model | MGI Sequence Detail 102174 C57BL/6J ±  kb
    transcript ENSMUST00000034811 Ensembl | MGI Sequence Detail 2373 Not Applicable  
    polypeptide ENSMUSP00000034811 Ensembl | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 6
      cDNA 15
      Primer pair 11
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11424, MGD-MRK-11430, MGD-MRK-2301
    References
    more
    • Summaries
      All 253
      Developmental Gene Expression 34
      Diseases 4
      Gene Ontology 13
      Phenotypes 144
    • Earliest
      J:34987 Naftolin F, et al., The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res. 1975;31:295-319
    • Latest
      J:353442 Luo X, et al., Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells. BMC Biol. 2024 Aug 26;22(1):176
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory