Marcksl1 MGI Mouse Gene Detail - MGI:97143

Symbol

Marcksl1
Name

MARCKS-like 1
Synonyms

D4Bc1, F52, MacMARCKS, Macs-2, Macs2, Macs-3, Macs3, Mlp, Mrp

Feature Type

protein coding gene
IDs

MGI:97143
NCBI Gene: 17357
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr4:129407374-129409774 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 63.26 cM
Mapping Data

4 experiments

SNPs within 2kb

41 from dbSNP Build 142
Strain Annotations

16
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97143	protein coding gene	Chr4:129407374-129409778 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028826	protein coding gene	Chr4:131436911-131439313 (+)
A/J	MGP_AJ_G0028785	protein coding gene	Chr4:126192351-126194754 (+)
AKR/J	MGP_AKRJ_G0028738	protein coding gene	Chr4:129697867-129700270 (+)
BALB/cJ	MGP_BALBcJ_G0028808	protein coding gene	Chr4:126788922-126791325 (+)
C3H/HeJ	MGP_C3HHeJ_G0028522	protein coding gene	Chr4:129762761-129765164 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029250	protein coding gene	Chr4:136384442-136386846 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0028488	protein coding gene	Chr4:139755262-139761436 (+)
DBA/2J	MGP_DBA2J_G0028637	protein coding gene	Chr4:126624146-126627044 (+)
FVB/NJ	MGP_FVBNJ_G0028604	protein coding gene	Chr4:125385241-125387643 (+)
LP/J	MGP_LPJ_G0028738	protein coding gene	Chr4:131715146-131717548 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028630	protein coding gene	Chr4:144594542-144596944 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029288	protein coding gene	Chr4:130076408-130080932 (+)
PWK/PhJ	MGP_PWKPhJ_G0027676	protein coding gene	Chr4:123220501-123223311 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019056	protein coding gene	Chr13:851727-852530 (+)
WSB/EiJ	MGP_WSBEiJ_G0028035	protein coding gene	Chr4:130197619-130199366 (+)

Human Ortholog

MARCKSL1, MARCKS like 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARCKSL1, MARCKS like 1
Synonyms

F52, MACMARCKS, MLP, MLP1, MRP
Links

HGNC:7142

NCBI Gene ID: 65108

neXtProt AC: NX_P49006

UniProt: P49006
Chr Location

1p35.1; chr1:32333839-32336233 (-) GRCh38

MGI Vertebrate Homology

Marcksl1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MARCKSL1
Gene Tree

Marcksl1

less

Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

26
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

4 involving Marcksl1
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit neural tube defects resulting in anencephaly, spina bifida, abnormal brain development, tail malformations, and neonatal lethality. A small percentage of heterozygotes also show neural tube defects.

less

All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

891
Tissues

166
cDNA Data

258
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase marcksl1

ZFIN marcksl1a, marcksl1b

less

All Sequences

40
RefSeq

2
UniProt

1
CCDS

CCDS18695.1

Ensembl

ENSMUSG00000047945 (Evidence)
NCBI Gene

17357

			Length	Strain/Species	Flank
genomic	17357	NCBI Gene Model \| MGI Sequence Detail	2401	C57BL/6J	± kb
transcript	NM_010807	RefSeq \| MGI Sequence Detail	1611	ZRU/MplStud
polypeptide	P28667	UniProt \| EBI \| MGI Sequence Detail	200	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000010185 MARCKS-related protein

(term hierarchy)
InterPro Domains

IPR002101 Myristoylated alanine-rich C-kinase substrate MARCKS

less

All nucleic 267

Genomic 2

cDNA 262

Primer pair 2

Other 1

Microarray probesets 5

less

MGD-MRK-12096, MGD-MRK-12097, MGD-MRK-12098, MGD-MRK-12099, MGD-MRK-12538, MGI:2140563, MGI:2146106, MGI:2146223

Summaries

All 64

Developmental Gene Expression 11

Gene Ontology 6

Phenotypes 15
Earliest

J:11364 Umekage T, et al., A mouse brain cDNA encodes a novel protein with the protein kinase C phosphorylation site domain common to MARCKS. FEBS Lett. 1991 Jul 29;286(1-2):147-51
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Marcksl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39158	Chr4:129406287-129406313 (+)	-1,074 bp
Tssr39159	Chr4:129406344-129406360 (+)	-1,022 bp
Tssr39160	Chr4:129407190-129407202 (+)	-178 bp
Tssr39161	Chr4:129407225-129407237 (+)	-143 bp
Tssr39162	Chr4:129407417-129407437 (+)	53 bp
Tssr39163	Chr4:129408550-129408567 (+)	1,185 bp
Tssr39164	Chr4:129408757-129408774 (+)	1,392 bp
Tssr39165	Chr4:129408928-129408973 (+)	1,577 bp
Tssr39166	Chr4:129409133-129409143 (+)	1,764 bp
Tssr39167	Chr4:129409289-129409301 (+)	1,921 bp
Tssr39168	Chr4:129409383-129409398 (+)	2,017 bp
Tssr39169	Chr4:129409412-129409435 (+)	2,050 bp
Tssr39170	Chr4:129409477-129409482 (+)	2,106 bp
Tssr39171	Chr4:129409598-129409637 (+)	2,244 bp
Tssr39172	Chr4:129409668-129409705 (+)	2,313 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24