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Kif3a Gene Detail
Summary
  • Symbol
    Kif3a
  • Name
    kinesin family member 3A
  • Synonyms
    Kif3, Kifl, kinesin-II subunit, Kns3, N-4 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:107689
    NCBI Gene: 16568
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53458206-53492794 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.97 cM, cytoband A5-B1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1242 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107689
 protein coding gene Chr11:53456531-53495075 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018299
 protein coding gene Chr11:52960391-52996448 (+)
A/J MGP_AJ_G0018268
 protein coding gene Chr11:50970918-51005400 (+)
AKR/J MGP_AKRJ_G0018238
 protein coding gene Chr11:52635020-52673292 (+)
BALB/cJ MGP_BALBcJ_G0018239
 protein coding gene Chr11:51327633-51362901 (+)
C3H/HeJ MGP_C3HHeJ_G0018050
 protein coding gene Chr11:52603387-52638812 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018691
 protein coding gene Chr11:54558392-54594731 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016341
 protein coding gene Chr11:48508500-48543031 (+)
CAST/EiJ MGP_CASTEiJ_G0017615
 protein coding gene Chr11:52651301-52686754 (+)
CBA/J MGP_CBAJ_G0018025
 protein coding gene Chr11:57143729-57178068 (+)
DBA/2J MGP_DBA2J_G0018135
 protein coding gene Chr11:50717768-50752586 (+)
FVB/NJ MGP_FVBNJ_G0018127
 protein coding gene Chr11:50360092-50395041 (+)
LP/J MGP_LPJ_G0018209
 protein coding gene Chr11:53406209-53442778 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018151
 protein coding gene Chr11:58454716-58489943 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018733
 protein coding gene Chr11:52670479-52705245 (+)
PWK/PhJ MGP_PWKPhJ_G0017390
 protein coding gene Chr11:51234326-51269290 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017185
 protein coding gene Chr11:52476027-52510244 (+)
WSB/EiJ MGP_WSBEiJ_G0017662
 protein coding gene Chr11:52303573-52337799 (+)



Homology
more
  • Human Ortholog
    KIF3A, kinesin family member 3A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF3A, kinesin family member 3A
  • Synonyms
    FLA10, KLP-20
  • Links
    NCBI Gene ID: 11127
    neXtProt AC: NX_Q9Y496
    UniProt: Q9Y496

  • Chr Location
    5q31.1; chr5:132688812-132737638 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Kif3a mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    104 phenotypes from 4 alleles in 10 genetic backgrounds
    5 phenotypes from multigenic genotypes
    9 images
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations result in embryonic lethality, failure to synthesize cilia in the embryonic node, randomization of left-right asymmetry and structural abnormalities of the neural tube, pericardium, branchial arches, and somites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    99
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    35
  • cDNA Data
    17
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018395 Ensembl Gene Model | MGI Sequence Detail 34589 C57BL/6J ±  kb
    transcript ENSMUST00000118353 Ensembl | MGI Sequence Detail 2178 Not Applicable  
    polypeptide ENSMUSP00000113848 Ensembl | MGI Sequence Detail 725 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 6
      cDNA 19
      Primer pair 4
      Other 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11592, MGD-MRK-36264, MGI:2136248, MGI:2136249, MGI:2144502, MGI:894290
    References
    more
    • Summaries
      All 193
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 39
      Phenotypes 115
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:347414 Yang J, et al., A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis. J Clin Invest. 2024 Mar 11;134(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory