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Mep1a Gene Detail
Summary
  • Symbol
    Mep1a
  • Name
    meprin 1 alpha
  • Synonyms
    Mep-1, Mep1, Mep-1a, meprin A alpha-subunit, meprin alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:96963
    NCBI Gene: 17287
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:43785215-43813703 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.73 cM, cytoband C1-D1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1194 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96963
 protein coding gene Chr17:43785215-43815034 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023774
 protein coding gene Chr17:44358080-44389283 (-)
A/J MGP_AJ_G0023732
 protein coding gene Chr17:43366019-43393174 (-)
AKR/J MGP_AKRJ_G0023703
 protein coding gene Chr17:43602179-43632553 (-)
BALB/cJ MGP_BALBcJ_G0023736
 protein coding gene Chr17:43254269-43282957 (-)
C3H/HeJ MGP_C3HHeJ_G0023500
 protein coding gene Chr17:44295435-44324605 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024179
 protein coding gene Chr17:46336451-46368793 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021629
 protein coding gene Chr17:40200453-40231538 (-)
CAST/EiJ MGP_CASTEiJ_G0022981
 protein coding gene Chr17:44320022-44347415 (-)
CBA/J MGP_CBAJ_G0023476
 protein coding gene Chr17:47993398-48019791 (-)
DBA/2J MGP_DBA2J_G0023602
 protein coding gene Chr17:42170996-42198098 (-)
FVB/NJ MGP_FVBNJ_G0023569
 protein coding gene Chr17:41729602-41758110 (-)
LP/J MGP_LPJ_G0023683
 protein coding gene Chr17:45024465-45055150 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023598
 protein coding gene Chr17:47621923-47657438 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024224
 protein coding gene Chr17:43954841-43982426 (-)
PWK/PhJ MGP_PWKPhJ_G0022726
 protein coding gene Chr17:41421060-41448047 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022541
 protein coding gene Chr17:40814068-40843026 (-)
WSB/EiJ MGP_WSBEiJ_G0023046
 protein coding gene Chr17:44472472-44502533 (-)



Homology
more
  • Human Ortholog
    MEP1A, meprin A subunit alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEP1A, meprin A subunit alpha
  • Synonyms
    PPHA
  • Links
    NCBI Gene ID: 4224
    neXtProt AC: NX_Q16819
    UniProt: Q16819

  • Chr Location
    6p12.3; chr6:46793389-46845984 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased litter size, reduced LPS-induced renal injury and bladder inflammation, and increased susceptibility to sodium dextran sulfate-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    18
  • cDNA Data
    163
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023914 Ensembl Gene Model | MGI Sequence Detail 28489 C57BL/6J ±  kb
    transcript ENSMUST00000024707 Ensembl | MGI Sequence Detail 2921 Not Applicable  
    polypeptide ENSMUSP00000024707 Ensembl | MGI Sequence Detail 760 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 171
      Genomic 6
      cDNA 165

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12193, MGD-MRK-12194, MGD-MRK-12196, MGD-MRK-12197, MGI:2146793, MGI:2147044
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:7573 Bond JS, et al., Mep-1 gene controlling a kidney metalloendopeptidase is linked to the major histocompatibility complex in mice. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5542-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory