Casp2 MGI Mouse Gene Detail - MGI:97295

Symbol

Casp2
Name

caspase 2
Synonyms

Caspase-2, Ich-1, Nedd2

Feature Type

protein coding gene
IDs

MGI:97295
NCBI Gene: 12366
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr6:42241942-42259442 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 20.54 cM
Mapping Data

4 experiments

SNPs within 2kb

537 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97295	protein coding gene	Chr6:42241919-42259442 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030645	protein coding gene	Chr6:40772569-40790095 (+)
A/J	MGP_AJ_G0030618	protein coding gene	Chr6:38993817-39011387 (+)
AKR/J	MGP_AKRJ_G0030543	protein coding gene	Chr6:40259141-40276714 (+)
BALB/cJ	MGP_BALBcJ_G0030628	protein coding gene	Chr6:39236683-39254262 (+)
C3H/HeJ	MGP_C3HHeJ_G0030341	protein coding gene	Chr6:40290674-40309216 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031082	protein coding gene	Chr6:41797355-41816436 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028289	protein coding gene	Chr6:36876119-36894084 (+)
CAST/EiJ	MGP_CASTEiJ_G0029745	protein coding gene	Chr6:40126230-40143779 (+)
CBA/J	MGP_CBAJ_G0030317	protein coding gene	Chr6:43486653-43504189 (+)
DBA/2J	MGP_DBA2J_G0030461	protein coding gene	Chr6:38844651-38862610 (+)
FVB/NJ	MGP_FVBNJ_G0030417	protein coding gene	Chr6:38590667-38608225 (+)
LP/J	MGP_LPJ_G0030549	protein coding gene	Chr6:40739260-40756782 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030451	protein coding gene	Chr6:45776008-45793531 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031112	protein coding gene	Chr6:40230504-40249053 (+)
PWK/PhJ	MGP_PWKPhJ_G0029457	protein coding gene	Chr6:38407645-38425226 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029293	protein coding gene	Chr6:39794025-39811628 (+)
WSB/EiJ	MGP_WSBEiJ_G0029821	protein coding gene	Chr6:40222354-40239840 (+)

Human Ortholog

CASP2, caspase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CASP2, caspase 2
Synonyms

CASP-2, ICH1, MRT80, NEDD-2, NEDD2, PPP1R57
Links

HGNC:1503

NCBI Gene ID: 835

neXtProt AC: NX_P42575

UniProt: P42575
Chr Location

7q34; chr7:143288215-143307696 (+) GRCh38

MGI Vertebrate Homology

Casp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CASP2
Protein SuperFamily

Caspase_ICE
Gene Tree

Casp2

Diseases

1 with human CASP2 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder IDs autosomal recessive intellectual developmental disorder DOID:0060308 OMIM:PS249500 ORDO:88616

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

23 phenotypes from 3 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
45 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Gene trapped

3
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in abnormal apoptosis. Apoptosis is reduced in the female germline, but is increased in sympathetic neurons during development.

less

All GO Annotations

41
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

846
Tissues

68
cDNA Data

22
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase casp2

ZFIN casp2

less

All Sequences

73
RefSeq

9
UniProt

2
CCDS

CCDS20064.1

Ensembl

ENSMUSG00000029863 (Evidence)
NCBI Gene

12366

			Length	Strain/Species	Flank
genomic	12366	NCBI Gene Model \| MGI Sequence Detail	17501	C57BL/6J	± kb
transcript	NR_176861	RefSeq \| MGI Sequence Detail	3625	ZRU/MplStud
polypeptide	P29594	UniProt \| EBI \| MGI Sequence Detail	452	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000002311 caspase-2

(term hierarchy)
EC

3.4.22.55
InterPro Domains

IPR001315 CARD domain

IPR035702 Caspase-2, CARD domain

IPR029030 Caspase-like domain superfamily

IPR011029 Death-like domain superfamily

IPR015917 Peptidase C14A, caspase catalytic domain

IPR011600 Peptidase C14, caspase domain

IPR002138 Peptidase C14, caspase non-catalytic subunit p10

IPR001309 Peptidase C14, p20 domain

IPR033139 Peptidase family C14A, cysteine active site

IPR016129 Peptidase family C14A, His active site

less

All nucleic 35

Genomic 5

cDNA 24

Primer pair 5

Other 1

Microarray probesets 4

less

MGD-MRK-12808

Summaries

All 128

Developmental Gene Expression 19

Gene Ontology 15

Phenotypes 45
Earliest

J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
Latest

J:349425 Wei SJ, et al., Ketogenic diet induces p53-dependent cellular senescence in multiple organs. Sci Adv. 2024 May 17;10(20):eado1463

TSS for Casp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56004	Chr6:42241917-42241966 (+)	0 bp
Tssr56005	Chr6:42241975-42242058 (+)	75 bp
Tssr56006	Chr6:42257779-42257782 (+)	15,839 bp
Tssr56007	Chr6:42259149-42259152 (+)	17,209 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24