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Ahsg Gene Detail
Summary
  • Symbol
    Ahsg
  • Name
    alpha-2-HS-glycoprotein
  • Synonyms
    fetuin-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107189
    NCBI Gene: 11625
  • Alliance
    gene page
  • Transcription Start Sites
    48 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22710793-22718193 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.74 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    306 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107189
 protein coding gene Chr16:22710027-22718199 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022674
 protein coding gene Chr16:20420645-20429667 (+)
A/J MGP_AJ_G0022635
 protein coding gene Chr16:19431767-19439163 (+)
AKR/J MGP_AKRJ_G0022610
 protein coding gene Chr16:20248547-20255943 (+)
BALB/cJ MGP_BALBcJ_G0022640
 protein coding gene Chr16:19632936-19640336 (+)
C3H/HeJ MGP_C3HHeJ_G0022404
 protein coding gene Chr16:20354002-20361398 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023090
 protein coding gene Chr16:20859340-20868716 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020608
 protein coding gene Chr16:20125206-20132792 (+)
CAST/EiJ MGP_CASTEiJ_G0021934
 protein coding gene Chr16:20353842-20361717 (+)
CBA/J MGP_CBAJ_G0022376
 protein coding gene Chr16:21733488-21742750 (+)
DBA/2J MGP_DBA2J_G0022508
 protein coding gene Chr16:19412289-19420241 (+)
FVB/NJ MGP_FVBNJ_G0022484
 protein coding gene Chr16:19382356-19389730 (+)
LP/J MGP_LPJ_G0022576
 protein coding gene Chr16:20172156-20179546 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022503
 protein coding gene Chr16:21275993-21284601 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023101
 protein coding gene Chr16:20192461-20199827 (+)
PWK/PhJ MGP_PWKPhJ_G0021674
 protein coding gene Chr16:19655884-19663757 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021504
 protein coding gene Chr16:19981838-19989226 (+)
WSB/EiJ MGP_WSBEiJ_G0021977
 protein coding gene Chr16:20157958-20166043 (+)



Homology
more
  • Human Ortholog
    AHSG, alpha 2-HS glycoprotein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AHSG, alpha 2-HS glycoprotein
  • Synonyms
    A2HS, AHS, APMR1, FETUA, HSGA
  • Links
    NCBI Gene ID: 197
    neXtProt AC: NX_P02765
    UniProt: P02765

  • Chr Location
    3q27.3; chr3:186613060-186621318 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human AHSG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice lacking this gene exhibit defective inhibition of serum apatite formation, sometimes causing muscle calcification. They are resistant to weight gain on a high-fat diet and have increased insulin sensitivity and glucose clearance and reduced fasting plasma free fatty acids and triglycerides.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    926
  • Tissues
    59
  • cDNA Data
    741
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11625 NCBI Gene Model | MGI Sequence Detail 7401 C57BL/6J ±  kb
    transcript NM_013465 RefSeq | MGI Sequence Detail 1478 ZRU/MplStud  
    polypeptide P29699 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000003862 alpha-2-HS-glycoprotein
      (term hierarchy)
    • InterPro Domains
      IPR000010 Cystatin domain
      IPR046350 Cystatin superfamily
      IPR025760 Fetuin-A-type cystatin domain
      IPR050735 Kininogen/Fetuin/Histidine-rich Glycoprotein
      IPR001363 Proteinase inhibitor I25C, fetuin, conserved site
    • GlyGen
      P29699 5 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 743
      cDNA 742
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-35650
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 11
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:31552 Yang F, et al., Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene. Biochim Biophys Acta. 1992 Mar 24;1130(2):149-56
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory