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Ccnd3 Gene Detail
Summary
  • Symbol
    Ccnd3
  • Name
    cyclin D3
  • Synonyms
    9230106B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88315
    NCBI Gene: 12445
  • Alliance
  • Transcription Start Sites
    71 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47815976-47910614 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 23.37 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2673 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88315
protein coding gene Chr17:47815976-47910616 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023847
protein coding gene Chr17:48675871-48799286 (+)
A/J MGP_AJ_G0023807
protein coding gene Chr17:47451104-47550417 (+)
AKR/J MGP_AKRJ_G0023776
protein coding gene Chr17:47835504-47957714 (+)
BALB/cJ MGP_BALBcJ_G0023809
protein coding gene Chr17:47364013-47461398 (+)
C3H/HeJ MGP_C3HHeJ_G0023572
protein coding gene Chr17:48586071-48692698 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024253
protein coding gene Chr17:50729718-50841654 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021702
protein coding gene Chr17:44207872-44304461 (+)
CAST/EiJ MGP_CASTEiJ_G0023053
protein coding gene Chr17:48690411-48804659 (+)
CBA/J MGP_CBAJ_G0023549
protein coding gene Chr17:52569554-52689532 (+)
DBA/2J MGP_DBA2J_G0023677
protein coding gene Chr17:46206446-46307116 (+)
FVB/NJ MGP_FVBNJ_G0023643
protein coding gene Chr17:45859375-45965178 (+)
LP/J MGP_LPJ_G0023757
protein coding gene Chr17:49354565-49454324 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023671
protein coding gene Chr17:52058228-52167182 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024298
protein coding gene Chr17:48200861-48319178 (+)
PWK/PhJ MGP_PWKPhJ_G0022799
protein coding gene Chr17:45572434-45678937 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022614
protein coding gene Chr17:45105570-45205066 (+)
WSB/EiJ MGP_WSBEiJ_G0023119
protein coding gene Chr17:48784819-48896215 (+)



Homology
more
  • Human Ortholog
    CCND3, cyclin D3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCND3, cyclin D3
  • Links
    NCBI Gene ID: 896
    neXtProt AC: NX_P30281
    UniProt: P30281

  • Chr Location
    6p21.1; chr6:41934933-42050357 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    31 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severe thymus hypoplasia, abnormal thymocyte development, and impaired expansion of immature T lymphocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12445 NCBI Gene Model | MGI Sequence Detail 94639 C57BL/6J ±  kb
    transcript NM_001081636 RefSeq | MGI Sequence Detail 2131 ZRU/MplStud  
    polypeptide P30282 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 28
      Primer pair 9
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1827, MGI:1924959, MGI:2146781, MGI:2146960, MGI:2147051, MGI:2147125
    References
    more
    • Summaries
      All 228
      Developmental Gene Expression 116
      Gene Ontology 16
      Phenotypes 46
    • Earliest
      J:14776 Matsushime H, et al., Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 1991 May 17;65(4):701-13
    • Latest
      J:352612 Caria CA, et al., Post-GWAS Validation of Target Genes Associated with HbF and HbA(2) Levels. Cells. 2024 Jul 12;13(14)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/05/2024
    MGI 6.24
    The Jackson Laboratory