F2r MGI Mouse Gene Detail - MGI:101802 - coagulation factor II thrombin receptor

Symbol

F2r
Name

coagulation factor II thrombin receptor
Synonyms

Cf2r, Par1, protease-activated receptor 1, thrombin receptor, ThrR

Feature Type

protein coding gene
IDs

MGI:101802
NCBI Gene: 14062
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:95738311-95754995 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 50.21 cM
Mapping Data

10 experiments

SNPs within 2kb

536 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101802	protein coding gene	Chr13:95738288-95754995 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020843	protein coding gene	Chr13:97083963-97102299 (-)
A/J	MGP_AJ_G0020797	protein coding gene	Chr13:93438226-93454844 (-)
AKR/J	MGP_AKRJ_G0020771	protein coding gene	Chr13:96291686-96312595 (-)
BALB/cJ	MGP_BALBcJ_G0020794	protein coding gene	Chr13:94117253-94134268 (-)
C3H/HeJ	MGP_C3HHeJ_G0020587	protein coding gene	Chr13:95983278-95999853 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021230	protein coding gene	Chr13:100026630-100044642 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018799	protein coding gene	Chr13:89269321-89286146 (-)
CAST/EiJ	MGP_CASTEiJ_G0020106	protein coding gene	Chr13:95290286-95307643 (-)
CBA/J	MGP_CBAJ_G0020546	protein coding gene	Chr13:104000280-104020028 (-)
DBA/2J	MGP_DBA2J_G0020671	protein coding gene	Chr13:93216348-93232980 (-)
FVB/NJ	MGP_FVBNJ_G0020652	protein coding gene	Chr13:92001524-92018129 (-)
LP/J	MGP_LPJ_G0020746	protein coding gene	Chr13:97194002-97212502 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020680	protein coding gene	Chr13:104434877-104451547 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021270	protein coding gene	Chr13:95694479-95712148 (-)
PWK/PhJ	MGP_PWKPhJ_G0019858	protein coding gene	Chr13:92000122-92017032 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019682	protein coding gene	Chr13:91986269-92004477 (-)
WSB/EiJ	MGP_WSBEiJ_G0020163	protein coding gene	Chr13:96197213-96215246 (-)

Human Ortholog

F2R, coagulation factor II thrombin receptor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

F2R, coagulation factor II thrombin receptor
Synonyms

CF2R, HTR, PAR-1, PAR1, TR
Links

HGNC:3537

NCBI Gene ID: 2149

neXtProt AC: NX_P25116

UniProt: P25116
Chr Location

5q13.3; chr5:76716126-76735770 (+) GRCh38

MGI Vertebrate Homology

F2r stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: F2R
Gene Tree

F2r

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Phenotype Summary

63 phenotypes from 4 alleles in 8 genetic backgrounds
21 phenotypes from multigenic genotypes
119 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Endonuclease-mediated

5
Gene trapped

5
Targeted

14
Transgenic

2
Genomic Mutations

1 involving F2r
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted mutations of this locus result in increased midgestational lethality, with up to ~50% of mutants surviving to adulthood. Gene deficiency does not affect thrombin signaling in mouse platelets but markedly attenuates thrombin signaling in mouse microvascular endothelial cells.

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All GO Annotations

101
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

951
Tissues

140
cDNA Data

11
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase f2r

ZFIN f2r

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All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS26701.1

Ensembl

ENSMUSG00000048376 (Evidence)
NCBI Gene

14062

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048376	Ensembl Gene Model \| MGI Sequence Detail	16685	C57BL/6J	± kb
transcript	ENSMUST00000059193	Ensembl \| MGI Sequence Detail	3336	Not Applicable
polypeptide	ENSMUSP00000061754	Ensembl \| MGI Sequence Detail	430	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001661 proteinase-activated receptor 1

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR003912 Protease-activated receptor

IPR000935 Thrombin receptor
GlyGen

P30558 3 sites

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All nucleic 27

Genomic 4

cDNA 11

Primer pair 6

Other 6

Microarray probesets 6

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MGD-MRK-18613, MGI:2145260

Summaries

All 198

Developmental Gene Expression 16

Gene Ontology 11

Phenotypes 119
Earliest

J:16414 Soifer SJ, et al., Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am J Pathol. 1994 Jan;144(1):60-9
Latest

J:344462 Julovi SM, et al., Involvement of PAR-2 in the Induction of Cell-Specific Matrix Metalloproteinase-2 by Activated Protein C in Cutaneous Wound Healing. Int J Mol Sci. 2023 Dec 27;25(1)

TSS for F2r:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123528	Chr13:95755170-95755177 (-)	-179 bp
Tssr123527	Chr13:95754987-95755006 (-)	-2 bp
Tssr123526	Chr13:95754950-95754983 (-)	28 bp
Tssr123525	Chr13:95754927-95754943 (-)	60 bp
Tssr123524	Chr13:95741411-95741421 (-)	13,579 bp
Tssr123523	Chr13:95741196-95741222 (-)	13,786 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24