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Htr5a Gene Detail
Summary
  • Symbol
    Htr5a
  • Name
    5-hydroxytryptamine (serotonin) receptor 5A
  • Synonyms
    Htr5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96283
    NCBI Gene: 15563
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:28046836-28059403 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 13.24 cM, cytoband A3-B
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    509 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96283
protein coding gene Chr5:28046836-28060086 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029367
protein coding gene Chr5:25724136-25736803 (+)
A/J MGP_AJ_G0029333
protein coding gene Chr5:24859722-24873488 (+)
AKR/J MGP_AKRJ_G0029284
protein coding gene Chr5:25833449-25847846 (+)
BALB/cJ MGP_BALBcJ_G0029344
protein coding gene Chr5:25376921-25392401 (+)
C3H/HeJ MGP_C3HHeJ_G0029065
protein coding gene Chr5:25939389-25952120 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029797
protein coding gene Chr5:27293757-27308474 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027035
protein coding gene Chr5:22514560-22527196 (+)
CAST/EiJ MGP_CASTEiJ_G0028476
protein coding gene Chr5:25033020-25045827 (+)
CBA/J MGP_CBAJ_G0029033
protein coding gene Chr5:27808860-27821898 (+)
DBA/2J MGP_DBA2J_G0029182
protein coding gene Chr5:25087249-25099937 (+)
FVB/NJ MGP_FVBNJ_G0029140
protein coding gene Chr5:24535979-24548658 (+)
LP/J MGP_LPJ_G0029267
protein coding gene Chr5:26163719-26177231 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029169
protein coding gene Chr5:28847025-28863333 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029831
protein coding gene Chr5:25496765-25509620 (+)
PWK/PhJ MGP_PWKPhJ_G0028200
protein coding gene Chr5:24155985-24169656 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028031
protein coding gene Chr5:24822524-24836149 (+)
WSB/EiJ MGP_WSBEiJ_G0028556
protein coding gene Chr5:25522608-25538913 (+)



Homology
more
  • Human Ortholog
    HTR5A, 5-hydroxytryptamine receptor 5A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR5A, 5-hydroxytryptamine receptor 5A
  • Synonyms
    5-HT5A
  • Links
    NCBI Gene ID: 3361
    neXtProt AC: NX_P47898
    UniProt: P47898

  • Chr Location
    7q36.2; chr7:155070324-155087392 (+)  GRCh38

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The are conflicting reports about mice with homozygous null alleles regarding increased exploratory behavior and an abnormal exploratory behavior response to LSD.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15563 NCBI Gene Model | MGI Sequence Detail 12568 C57BL/6J ±  kb
transcript NM_008314 RefSeq | MGI Sequence Detail 5004 C57BL/6  
polypeptide P30966 UniProt | EBI | MGI Sequence Detail 357 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 3
    cDNA 10
    Primer pair 4
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11010, MGD-MRK-11011
References
more
  • Summaries
    All 67
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 6
    Phenotypes 31
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:240101 Lv J, et al., 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017 Feb;214(2):529-545

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory