Ctnnd1 MGI Mouse Gene Detail - MGI:105100

Symbol

Ctnnd1
Name

catenin delta 1
Synonyms

catenin (cadherin associated protein), delta 1, Catns, Ctnnd, mKIAA0384, P120, p120-catenin

Feature Type

protein coding gene
IDs

MGI:105100
NCBI Gene: 12388
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr2:84430415-84481109 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM
Mapping Data

4 experiments

SNPs within 2kb

966 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105100	protein coding gene	Chr2:84417440-84489321 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025900	protein coding gene	Chr2:85281973-85333245 (-)
A/J	MGP_AJ_G0025874	protein coding gene	Chr2:81976100-82026775 (-)
AKR/J	MGP_AKRJ_G0025844	protein coding gene	Chr2:84090069-84143824 (-)
BALB/cJ	MGP_BALBcJ_G0025871	protein coding gene	Chr2:82113645-82164711 (-)
C3H/HeJ	MGP_C3HHeJ_G0025630	protein coding gene	Chr2:84339093-84392839 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026317	protein coding gene	Chr2:87923453-87973934 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023719	protein coding gene	Chr2:78810767-78863078 (-)
CAST/EiJ	MGP_CASTEiJ_G0025091	protein coding gene	Chr2:84850923-84911606 (-)
CBA/J	MGP_CBAJ_G0025611	protein coding gene	Chr2:91067956-91125012 (-)
DBA/2J	MGP_DBA2J_G0025742	protein coding gene	Chr2:81522977-81573912 (-)
FVB/NJ	MGP_FVBNJ_G0025705	protein coding gene	Chr2:80764127-80817593 (-)
LP/J	MGP_LPJ_G0025830	protein coding gene	Chr2:85080347-85134926 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025735	protein coding gene	Chr2:93380185-93460533 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026373	protein coding gene	Chr2:84318757-84370330 (-)
PWK/PhJ	MGP_PWKPhJ_G0024835	protein coding gene	Chr2:81355046-81407369 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024639	protein coding gene	Chr2:84473078-84524210 (-)
WSB/EiJ	MGP_WSBEiJ_G0025161	protein coding gene	Chr2:84995413-85046667 (-)

Human Ortholog

CTNND1, catenin delta 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTNND1, catenin delta 1
Synonyms

BCDS2, CAS, CTNND, p120, p120(CAS), P120CAS, p120(CTN), P120CTN
Links

HGNC:2515

NCBI Gene ID: 1500

neXtProt AC: NX_O60716

UniProt: O60716
Chr Location

11q12.1; chr11:57753243-57819546 (+) GRCh38

MGI Vertebrate Homology

Ctnnd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CTNND1
Gene Tree

Ctnnd1

Diseases

1 with human CTNND1 associations

				Human Disease	Mouse Models
				blepharocheilodontic syndrome 2 IDs blepharocheilodontic syndrome 2 DOID:0080346 OMIM:617681

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

43 phenotypes from 2 alleles in 5 genetic backgrounds
47 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

7
Genomic Mutations

3 involving Ctnnd1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

122 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions of this gene die shortly after birth and have morphological abnormalities of the salivary glands and lacrimal gland.

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All GO Annotations

73
GO References

24

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

867
Tissues

124
cDNA Data

277
Literature Summary

57

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctnnd1

ZFIN ctnnd1

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All Sequences

151
RefSeq

52
UniProt

1
CCDS

CCDS16186.1, CCDS50621.1, CCDS50622.1, CCDS50623.1, CCDS89504.1

Ensembl

ENSMUSG00000034101 (Evidence)
NCBI Gene

12388

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034101	Ensembl Gene Model \| MGI Sequence Detail	50695	C57BL/6J	± kb
transcript	ENSMUST00000111694	Ensembl \| MGI Sequence Detail	6362	Not Applicable
polypeptide	ENSMUSP00000107323	Ensembl \| MGI Sequence Detail	967	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006012 catenin delta-1

(term hierarchy)
GlyGen

P30999 7 sites, 9 N-linked glycans (5 sites), 1 O-linked glycan (2 sites)

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All nucleic 282

Genomic 1

cDNA 277

Primer pair 3

Other 1

Microarray probesets 6

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MGD-MRK-28063, MGD-MRK-32140, MGI:2138768, MGI:2139175

Summaries

All 174

Developmental Gene Expression 57

Gene Ontology 24

Phenotypes 47
Earliest

J:29846 Reynolds AB, et al., p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. Oncogene. 1992 Dec;7(12):2439-45
Latest

J:354189 Miao L, et al., beta1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation. Cardiovasc Res. 2024 Sep 21;120(11):1279-1294

TSS for Ctnnd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25017	Chr2:84481104-84481115 (-)	-1 bp
Tssr25016	Chr2:84481058-84481093 (-)	33 bp
Tssr25015	Chr2:84481042-84481053 (-)	61 bp
Tssr25014	Chr2:84481023-84481031 (-)	82 bp
Tssr25013	Chr2:84480893-84480924 (-)	200 bp
Tssr25012	Chr2:84480834-84480888 (-)	248 bp
Tssr25011	Chr2:84480813-84480831 (-)	287 bp
Tssr25010	Chr2:84478897-84478908 (-)	2,206 bp
Tssr25008	Chr2:84468031-84468034 (-)	13,076 bp
Tssr25007	Chr2:84466060-84466086 (-)	15,036 bp
Tssr25006	Chr2:84431860-84431891 (-)	49,233 bp
Tssr25005	Chr2:84431801-84431835 (-)	49,291 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24